The evolution of functionally novel proteins after gene duplication

Molecular Evolutionary Genetics

1987 • 15,266 citations

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Evolution by Gene Duplication

1970 • 6,000 citations

Evolution by gene duplication

1970 • 5,849 citations

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

Evolution of genes and proteins.

1983 • 1,224 citations

ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION

1976 • 1,071 citations

Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

1989 • 893 citations

EVOLUTION FROM FISH TO MAMMALS BY GENE DUPLICATION

2009 • 709 citations

On Some Principles Governing Molecular Evolution

1974 • 505 citations

Evolution of the alpha-crystallin/small heat-shock protein family.

1993 • 464 citations

The family of genes encoding odorant receptors in the channel catfish

1993 • 402 citations

Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression

1986 • 395 citations

Ancient Linkage Groups and Frozen Accidents

1973 • 338 citations

The Recruitment of Crystallins: New Functions Precede Gene Duplication

1991 • 335 citations

Evolution of the major histocompatibility complex.

1986 • 326 citations

Darwinian evolution in the genealogy of haemoglobin

1975 • 306 citations

Structure of the Adrenergic and Related Receptors

1989 • 300 citations

Accelerated evolution in the reactive centre regions of serine protease inhibitors

1987 • 293 citations

Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.

1990 • 287 citations

Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection

1990 • 286 citations

Gene sharing by delta-crystallin and argininosuccinate lyase.

1988 • 261 citations

Evolution of duplicate genes in a tetraploid animal, Xenopus laevis.

1993 • 228 citations

Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals.

1989 • 228 citations

Positive darwinian selection observed at the variable-region genes of immunoglobulins.

1989 • 206 citations

H-2M3 presents a listeria monocytogenes peptide to cytotoxic T lymphocytes

1992 • 203 citations

The genealogy of some recently evolved vertebrate proteins

1985 • 179 citations

Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein.

1988 • 154 citations

Gene duplication in tetraploid fish: model for gene silencing at unlinked duplicated loci.

1978 • 141 citations

Squid major lens polypeptides are homologous to glutathione S-transferases subunits

1988 • 129 citations

Duck lens epsilon-crystallin and lactate dehydrogenase B4 are identical: a single-copy gene product with two distinct functions.

1988 • 115 citations

Evolutionary relationships of class II major-histocompatibility-complex genes in mammals.

1990 • 101 citations

Polymorphism and loss of duplicate gene expression: a theoretical study with application of tetraploid fish.

1979 • 77 citations

Evolution and vertebrate immunity : the antigen-receptor and MHC gene families

1987 • 68 citations

Evolutionary relationships of the classes of major histocompatibility complex genes

1993 • 62 citations

Adaptive evolution in the rat olfactory receptor gene family

1993 • 54 citations

Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.

1993 • 46 citations

Coevolution of the vertebrate integrin alpha- and beta-chain genes.

1992 • 33 citations

Evolution of Cysteine Proteinases in Eukaryotes

1994 • 25 citations

The partitioning of biochemical pathways with isozyme systems.

1981 • 14 citations

Deleted Work

1955 • 0 citations