Population Biology of Antigen Presentation by MHC Class I Molecules

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

Evolutionary Rate at the Molecular Level

1968 • 3,608 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

Common West African HLA antigens are associated with protection from severe malaria

1991 • 1,570 citations

Biology of the Mouse Histocompatibility-2 Complex

1975 • 1,145 citations

Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

1989 • 893 citations

STRUCTURE, FUNCTION, AND DIVERSITY OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES

1990 • 693 citations

Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution

1977 • 666 citations

Map of the human MHC

1993 • 585 citations

Evolutionary Significance of the HL-A System

1972 • 523 citations

The Settlement of the Americas: A Comparison of the Linguistic, Dental, and Genetic Evidence [and Comments and Reply]

1986 • 480 citations

Origin of major histocompatibility complex polymorphism: The trans-species hypothesis

1987 • 450 citations

The Settlement of the Americas: A Comparison of the Linguistic, Dental, and Genetic Evidence

1986 • 371 citations

The Molecular Descent of the Major Histocompatibility Complex

1993 • 334 citations

EVIDENCE FOR BALANCING SELECTION AT HLA

1983 • 329 citations

Evolution of the major histocompatibility complex.

1986 • 326 citations

IS THE GENE THE UNIT OF SELECTION?

1970 • 290 citations

Unusual HLA-B alleles in two tribes of Brazilian Indians

1992 • 288 citations

“Self-recognition” in Colonial Marine Forms and Flowering Plants in relation to the Evolution of Immunity

1971 • 288 citations

Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection

1990 • 286 citations

Maintenance of Histocompatibility Polymorphisms

1966 • 248 citations

The Colonization of Beringia and the Peopling of the New World

1993 • 205 citations

The Myth of Eve: Molecular Biology and Human Origins: F. J. Ayala

1995 • 174 citations

Why Did They Die?

1992 • 154 citations

Molecular Biology of the H-2 Histocompatibility Complex

1986 • 149 citations

Man's place in Hominoidea as inferred from molecular clocks of DNA

1987 • 145 citations

Evolution of the major histocompatibility complex

1986 • 142 citations

Natural selection on the peptide-binding regions of major histocompatibility complex molecules

1995 • 137 citations

Consensus motifs and peptide ligands of MHC class I molecules

1993 • 118 citations

Genetic diversity at class II DRB loci of the primate MHC.

1991 • 115 citations

MHC polymorphism and parasites

1994 • 110 citations

Biochemical comparison of major histocompatibility complex molecules from different subspecies of Mus musculus: evidence for trans-specific evolution of alleles.

1982 • 109 citations

A Certain Symmetry : Histocompatibility Antigens compared with Immunocyte Receptors

1970 • 104 citations

Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.

1991 • 102 citations

Organic Synthesis of Prostaglandins: Advancing Biology

1993 • 99 citations

HLA‐B15: A widespread and diverse family of HLA‐B alleles

1994 • 93 citations

Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes

1995 • 92 citations

Molecular genetics of speciation and human origins.

1994 • 83 citations

Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30.

1989 • 82 citations

Natural selection at the class II major histocompatibility complex loci of mammals

1997 • 82 citations

Human leukocyte antigens and natural selection by malaria

1994 • 79 citations

MHC Polymorphism and Human Origins

1993 • 79 citations

Shared epitopes among HLA class II alleles: gene conversion, common ancestry and balancing selection

1991 • 75 citations

Origin and evolution of HLA class I pseudogenes.

1995 • 73 citations

Evidence for heterosis in the HLA system.

1981 • 70 citations

Evolutionary relationships of the classes of major histocompatibility complex genes

1993 • 62 citations

Contrasting roles of interallelic recombination at the HLA-A and HLA-B loci.

1993 • 58 citations

Geneticists Trace the DNA Trail of the First Americans

1993 • 55 citations

Trans‐specific Mhc polymorphism and the origin of species in primates

1993 • 55 citations

Human migrations and linkage disequilibrium ofHL-A system

1974 • 54 citations

A sixth family of HLA‐A alleles defined by HLA‐A*8001

1993 • 51 citations

Gene conversion in the evolution of the human and chimpanzee MHC class I loci

1991 • 50 citations

Mysteries of the Amerindians

1981 • 48 citations

Composite origin of major histocompatibility complex genes

1993 • 46 citations

HLA-B alleles of the Cayapa of Ecuador: new B39 and B15 alleles

1995 • 43 citations

Heterozygosity of H–2 loci in wild mice

1979 • 43 citations

Grenville Front and Rifting of the Canadian Shield

1972 • 43 citations

Advances in DNA-based HLA-typing methods

1994 • 42 citations

Polymorphism in mouse and human class I H-2 and HLA genes is not the result of random independent point mutations

1985 • 39 citations

Recombination and the concerted evolution of the murine MHC

1987 • 37 citations

Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins

1995 • 37 citations

The Mystery of Humanity's Missing Mutations

1995 • 34 citations

Evolution at HLA: Possible Explanations for the Deficiency of Homozygotes in Two Populations

1990 • 30 citations

The evolution of allelic diversity at the primate major histocompatibility complex class II loci

1991 • 20 citations

Maintenance of MHC polymorphism

1992 • 18 citations

Interrelationships between Amerindian tribes of lower Amazonia as manifest by HLA haplotype disequilibria.

1984 • 17 citations

Early events in the assembly of MHC class I antigens

1993 • 10 citations