PPAR∞ AND GLUCOSE HOMEOSTASIS

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

1999 • 4,825 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

2001 • 3,408 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1999 • 1,963 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Transcriptional regulation of adipogenesis

2000 • 1,875 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

2001 • 1,659 citations

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

1999 • 1,350 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

Pharmacologic Therapy for Type 2 Diabetes Mellitus

1999 • 1,196 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.

1996 • 1,169 citations

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

2001 • 1,144 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

2001 • 1,091 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 • 1,050 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

1998 • 995 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

2000 • 877 citations

Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues

2000 • 862 citations

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years

1998 • 856 citations

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

1998 • 798 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

1997 • 789 citations

Life without white fat: a transgenic mouse

1998 • 782 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 • 702 citations

GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.

1996 • 702 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

1997 • 697 citations

Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome 3q27-qter and Independent Replication of a Type 2–Diabetes Locus on Chromosome 1q21–q24

2000 • 686 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1996 • 654 citations

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

1995 • 648 citations

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

2000 • 646 citations

Economic Consequences of Diabetes Mellitus in the U.S. in 1997

1998 • 642 citations

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome

2000 • 638 citations

The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

2001 • 634 citations

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1997 • 614 citations

PPARγ, the ultimate thrifty gene

1999 • 609 citations

Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease

2001 • 581 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors

2000 • 563 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

Effect of Metformin and Rosiglitazone Combination Therapy in Patients With Type 2 Diabetes Mellitus

2000 • 547 citations

Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site

1997 • 544 citations

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

2001 • 536 citations

Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators

1997 • 533 citations

Molecular determinants of nuclear receptor-corepressor interaction

1999 • 516 citations

Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (hPPARγ) Gene in Diabetic Caucasians: Identification of a Pro12Ala PPARγ2 Missense Mutation

1997 • 498 citations

Peroxisome proliterator-activated receptors, orphans with ligands and functions

1997 • 494 citations

Rat PPARs: Quantitative Analysis in Adult Rat Tissues and Regulation in Fasting and Refeeding

2001 • 463 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

1998 • 442 citations

Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects

1992 • 423 citations

Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists

2001 • 419 citations

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

1999 • 412 citations

Improved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone

2001 • 405 citations

Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency

2000 • 401 citations

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter

1995 • 396 citations

An Essential Regulator of Adipogenesis and Modulator of Fat Cell Function: PPARγ

1999 • 384 citations

β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats

2001 • 374 citations

Cardiac and Glycemic Benefits of Troglitazone Treatment in NIDDM

1997 • 372 citations

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

1994 • 371 citations

Evidence for Gene-Nutrient Interaction at the PPARγ Locus

2001 • 368 citations

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

2000 • 367 citations

A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation

2000 • 365 citations

Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

2000 • 363 citations

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.

1996 • 362 citations

PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.

1998 • 349 citations

A Randomized Trial of Rosiglitazone Therapy in Patients With Inadequately Controlled Insulin-Treated Type 2 Diabetes

2001 • 349 citations

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

2001 • 348 citations

Effects of Pioglitazone on Adipose Tissue Remodeling Within the Setting of Obesity and Insulin Resistance

2001 • 347 citations

Depot-Specific Differences in Adipose Tissue Gene Expression in Lean and Obese Subjects

1998 • 345 citations

Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.

1996 • 342 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

Effect of Troglitazone in Insulin-Treated Patients with Type II Diabetes Mellitus

1998 • 337 citations

PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter

1998 • 334 citations

Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues

2001 • 334 citations

Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes.

1999 • 324 citations

Activation of PPARδ alters lipid metabolism in db/db mice

2000 • 313 citations

A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation

1999 • 309 citations

Hormonal Signaling and Transcriptional Control of Adipocyte Differentiation

2000 • 303 citations

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations.

1998 • 302 citations

N-(2-Benzoylphenyl)-<scp>l</scp>-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents

1998 • 300 citations

Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

1998 • 293 citations

Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR-α) and PPAR-γ Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR-γ-Responsive Adipose Tissue-Specific Genes in the Liver of Obese Diabetic Mice**This work was supported by grants from the Research Service of the Department of Veterans Affairs (to C.G. and K.R.F.), NIH Grant DK-49448 (to C.G.), and Merck Research Laboratories (to L.H.T. and K.N.).

2000 • 289 citations

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

2001 • 288 citations

Lessons from the glitazones: a story of drug development

2001 • 287 citations

Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat

1997 • 286 citations

Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

2001 • 286 citations

Effect of troglitazone on body fat distribution in type 2 diabetic patients.

1999 • 282 citations

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

1997 • 277 citations

Ligand-independent Activation Domain in the N Terminus of Peroxisome Proliferator-activated Receptor γ (PPARγ)

1997 • 276 citations

The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes

2000 • 274 citations

A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity

2001 • 270 citations

Addition of low‐dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients

2000 • 265 citations

A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.

1998 • 258 citations

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

1998 • 252 citations

New Oral Therapies for Type 2 Diabetes Mellitus: The Glitazones or Insulin Sensitizers

2001 • 250 citations

Circulating Tumor Necrosis Factor-α Concentrations in a Native Canadian Population with High Rates of Type 2 Diabetes Mellitus1

1999 • 244 citations

The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population

2001 • 241 citations

Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

1999 • 238 citations

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

2001 • 231 citations

p300 Interacts with the N- and C-terminal Part of PPARγ2 in a Ligand-independent and -dependent Manner, Respectively

1999 • 224 citations

A Regulatory Role for RIP140 in Nuclear Receptor Activation

1998 • 222 citations

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

1997 • 217 citations

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

1994 • 217 citations

Rosiglitazone short-term monotherapy lowers fasting and post-prandial glucose in patients with Type II diabetes

2000 • 214 citations

Hepatic Failure in a Patient Taking Rosiglitazone

2000 • 211 citations

Adipose Tissue Distribution Pattern in Patients with Familial Partial Lipodystrophy (Dunnigan Variety)¹

1999 • 208 citations

Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-γ2 (PPAR-γ2): divergent modulating effects on body mass index in obese and lean Caucasian men

1999 • 199 citations

Fenofibrate and Rosiglitazone Lower Serum Triglycerides with Opposing Effects on Body Weight

2000 • 198 citations

Peroxisome proliferator-activated receptor ? activators inhibit interleukin-1?-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes

2001 • 198 citations

Thiazolidinediones and insulin resistance: Peroxisome proliferatoractivated receptor γ activation stimulates expression of the CAP gene

1998 • 197 citations

Hepatocellular Injury in a Patient Receiving Rosiglitazone: A Case Report

2000 • 196 citations

Isolation and Characterization of Peroxisome Proliferator-activated Receptor (PPAR) Interacting Protein (PRIP) as a Coactivator for PPAR

2000 • 193 citations

Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome

1999 • 192 citations

Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells

2000 • 191 citations

Ligand type-specific Interactions of Peroxisome Proliferator-activated Receptor γ with Transcriptional Coactivators

2000 • 189 citations

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

1997 • 183 citations

Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus

2000 • 177 citations

Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma.

1996 • 176 citations

Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action

2000 • 175 citations

Insulin Sensitivity and Acute Insulin Response in African-Americans, Non-Hispanic Whites, and Hispanics With NIDDM: The Insulin Resistance Atherosclerosis Study

1997 • 174 citations

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells.

1995 • 170 citations

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

1999 • 169 citations

Obesity and diabetes in TNF-alpha receptor- deficient mice.

1998 • 168 citations

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

2000 • 167 citations

In vitro studies on the action of CS-045, a new antidiabetic agent

1990 • 165 citations

Pro12Ala Missense Mutation of the Peroxisome Proliferator Activated Receptor γ and Diabetes Mellitus

1999 • 157 citations

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ∞ AND METABOLIC DISEASE

2001 • 156 citations

Regulation of Lipoprotein Metabolism by Thiazolidinediones Occurs through a Distinct but Complementary Mechanism Relative to Fibrates

1997 • 146 citations

Troglitazone Induces GLUT4 Translocation in L6 Myotubes

2001 • 141 citations

Interactions between Subunits of the Human Epithelial Sodium Channel

1997 • 140 citations

Troglitazone in Combination With Sulfonylurea Restores Glycemic Control in Patients With Type 2 Diabetes

1998 • 140 citations

The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes

2000 • 137 citations

Effect of the Pro12Ala Variant of the Human Peroxisome Proliferator-Activated Receptor γ2 Gene on Adiposity, Fat Distribution, and Insulin Sensitivity in Japanese Men

1998 • 135 citations

A Selective Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes

2000 • 134 citations

PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

1998 • 134 citations

Identification of Nuclear Receptor Corepressor as a Peroxisome Proliferator-activated Receptor α Interacting Protein

1999 • 134 citations

Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor γ

1999 • 133 citations

The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant

2001 • 133 citations

Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes.

1999 • 133 citations

Does Intra-Abdominal Adipose Tissue in Black Men Determine Whether NIDDM Is Insulin-Resistant or Insulin-Sensitive?

1995 • 132 citations

Regulation of Gene Expression by Activation of the Peroxisome Proliferator-Activated Receptor γ with Rosiglitazone (BRL 49653) in Human Adipocytes

1999 • 131 citations

Role of Skeletal Muscle in Thiazolidinedione Insulin Sensitizer (PPARγ Agonist) Action

1998 • 131 citations

Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.

2000 • 129 citations

Thiazolidinedione Exposure Increases the Expression of Uncoupling Protein 1 in Cultured Human Preadipocytes

1998 • 129 citations

Activation of retinoic X receptor and peroxisome proliferator–activated receptor-γ inhibits nitric oxide and tumor necrosis factor-α production in rat Kupffer cells

2001 • 128 citations

Thiazolidinediones (PPARγ agonists) but not PPAR α agonists increase IRS‐2 gene expression in 3T3‐L1 and human adipocytes¹

2001 • 127 citations

Systemic Bias of Cytokine Production Toward Cell-Mediated Immune Regulation in IDDM and Toward Humoral Immunity in Graves' Disease

1997 • 124 citations

Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter.

2000 • 122 citations

The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat

1997 • 121 citations

An adipogenic cofactor bound by the differentiation domain of PPARgamma

1999 • 119 citations

A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity

2001 • 118 citations

Troglitazone Reduces Plasma Leptin Concentration but Increases Hunger in NIDDM Patients

1998 • 116 citations

Differential Effects of Rexinoids and Thiazolidinediones on Metabolic Gene Expression in Diabetic Rodents

2001 • 115 citations

Insulin Downregulates Pyruvate Dehydrogenase Kinase (PDK) mRNA: Potential Mechanism Contributing to Increased Lipid Oxidation in Insulin-Resistant Subjects

1998 • 114 citations

N-(2-Benzoylphenyl)-<scp>l</scp>-tyrosine PPARγ Agonists. 3. Structure−Activity Relationship and Optimization of the N-Aryl Substituent

1998 • 112 citations

Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ

2001 • 111 citations

Effects of troglitazone and metformin on glucose and lipid metabolism

1997 • 110 citations

Peroxisome Proliferator-Activated Receptor (PPAR) γ and Retinoid X Receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle

2001 • 109 citations

An Autopsy Case of Troglitazone-Induced Fulminant Hepatitis

1998 • 107 citations

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes

1999 • 97 citations

Interactions Between Variants in the β3-Adrenergic Receptor and Peroxisome Proliferator–Activated Receptor-γ2 Genes and Obesity

2001 • 96 citations

Effect of Troglitazone on Insulin Sensitivity and Pancreatic β-Cell Function in Women at High Risk for NIDDM

1996 • 93 citations

Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity

2001 • 91 citations

Regional and gender variations in adipose tissue lipolysis in response to weight loss

1999 • 90 citations

N-(2-Benzoylphenyl)-<scp>l</scp>-tyrosine PPARγ Agonists. 2. Structure−Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety

1998 • 85 citations

Expression of Peroxisome Proliferator-Activated Receptor γ (PPARγ) in Rat Aortic Smooth Muscle Cells

1998 • 85 citations

Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus.

1998 • 85 citations

Tumor Necrosis Factor α-induced Pancreatic β-Cell Insulin Resistance Is Mediated by Nitric Oxide and Prevented by 15-Deoxy-Δ12,14-prostaglandin J2 and Aminoguanidine

1999 • 82 citations

Effect of Experimental Elevation of Free Fatty Acids on Insulin Secretion and Insulin Sensitivity in Healthy Carriers of the Pro12Ala Polymorphism of the Peroxisome Proliferator–Activated Receptor-γ2 Gene

2001 • 78 citations

Cloning and Characterization of a Functional Peroxisome Proliferator Activator Receptor-γ-responsive Element in the Promoter of the CAP Gene

2000 • 76 citations

Thiazolidinedione toxicity to isolated hepatocytes revealed by coherent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes

2001 • 66 citations

Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects.

2000 • 63 citations

Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes.

1994 • 57 citations

Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle

1993 • 57 citations

Effects of Troglitazone on Cellular Differentiation, Insulin Signaling, and Glucose Metabolism in Cultured Human Skeletal Muscle Cells

2001 • 57 citations

A potent in vivo effect of ciglitazone on muscle insulin resistance induced by high fat feeding of rats

1989 • 56 citations

Prostaglandin J2 Inhibition of Mesangial Cell iNOS Expression

2001 • 55 citations

Losing the battle of the bulge: causes and consequences of increasing obesity

2001 • 55 citations

Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative

1999 • 52 citations

The Pro12Ala substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia

2000 • 51 citations

Effects of troglitazone on insulin action and cardiovascular risk factors in patients with non-insulin-dependent diabetes

1997 • 51 citations

The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat

2000 • 49 citations

Insulin Therapy in Type II Diabetes

1993 • 47 citations

Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.

1998 • 45 citations

Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the zucker diabetic fatty rat

2001 • 45 citations

Decreased Expression of Murine PPARγ in Adipose Tissue during Endotoxemia

1997 • 44 citations

Actions of novel antidiabetic thiazolidinedione, T‐174, in animal models of non‐insulin‐dependent diabetes mellitus (NIDDM) and in cultured muscle cells

1998 • 40 citations

Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.

2000 • 38 citations

Nitric Oxide Production by Adipocytes: A Role in the Pathogenesis of Insulin Resistance?

2000 • 37 citations

Effects of pioglitazone on promoting energy storage, not expenditure, in brown adipose tissue of obese fa/fa zucker rats: comparison to cl 316,243

2000 • 34 citations

Frequency and Significance of Pro12Ala and Pro115Gln Polymorphism in Gene for Peroxisome Proliferation-Activated Receptor-γ&lt;sub&gt;2&lt;/sub&gt; Regarding Metabolic Parameters in a Caucasian Cohort

2001 • 34 citations

Nitric oxide mediates endotoxin‐induced hypertriglyceridemia through its action on skeletal muscle lipoprotein lipase

2001 • 30 citations

Troglitazone can prevent development of type 1 diabetes induced by multiple low-dose streptozotocin in mice

1999 • 30 citations

Pioglitazone-induced increase of insulin sensitivity in the muscles of the obese Zucker fa/fa rat cannot be explained by local adipocyte differentiation

1998 • 26 citations

The European Association for the Study of Diabetes Annual Meeting, 1998. Treatment of type 2 diabetes and the pathogenesis of complications.

1999 • 19 citations

American Diabetes Association Annual Meeting, 1998. Treatment of type 2 diabetes.

1999 • 12 citations

Insulin oedema: an uncommon complication of insulin therapy.

1991 • 6 citations

4.P.263 Coordinate regulation of the expression of the fatty acid transporter protein (FATP) and acyl CoA synthetase (ACS) genes by PPARα and PPARγ activators

1997 • 3 citations