PPARγ, the ultimate thrifty gene

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

1997 • 1,183 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

1996 • 1,036 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

1996 • 1,004 citations

Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity

1999 • 976 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

1995 • 922 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

1997 • 789 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

1998 • 733 citations

Nuclear receptor coactivators

1997 • 720 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

1998 • 609 citations

Peroxisome Proliferator-Activated Receptor Gamma Activators Inhibit Gene Expression and Migration in Human Vascular Smooth Muscle Cells

1998 • 594 citations

Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids

1996 • 590 citations

Molecular Diagnosis of Familial Adenomatous Polyposis

1993 • 588 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

RNA Helicase A Mediates Association of CBP with RNA Polymerase II

1997 • 532 citations

Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes

1997 • 463 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

p300 is a component of an estrogen receptor coactivator complex.

1996 • 399 citations

Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

1995 • 397 citations

Cardiac and Glycemic Benefits of Troglitazone Treatment in NIDDM

1997 • 372 citations

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.

1993 • 351 citations

Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes.

1996 • 342 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

Isolation and Characterization of PBP, a Protein That Interacts with Peroxisome Proliferator-activated Receptor

1997 • 340 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter

1998 • 334 citations

Dietary Factors and Risk of Colon Cancer

1994 • 333 citations

Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells

1998 • 319 citations

Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity

1989 • 303 citations

Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations.

1998 • 302 citations

Transcriptional control of adipogenesis

1998 • 301 citations

Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors

1997 • 279 citations

Ligand-independent Activation Domain in the N Terminus of Peroxisome Proliferator-activated Receptor γ (PPARγ)

1997 • 276 citations

Peroxisome Proliferator Activated Receptor γ, CCAAT/ Enhancer-binding Protein α, and Cell Cycle Status Regulate the Commitment to Adipocyte Differentiation

1997 • 272 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARγ

1998 • 256 citations

SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.

1996 • 244 citations

Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.

1992 • 243 citations

Inhibition of Inducible Nitric Oxide Synthase by Peroxisome Proliferator-Activated Receptor Agonists: Correlation with Induction of Heme Oxygenase 1

1998 • 241 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

p300 Interacts with the N- and C-terminal Part of PPARγ2 in a Ligand-independent and -dependent Manner, Respectively

1999 • 224 citations

Expression of the Peroxisome Proliferator-Activated Receptor (PPAR) in the Mouse Colonic Mucosa

1996 • 213 citations

TNFα-Mediated Inhibition and Reversal of Adipocyte Differentiation Is Accompanied by Suppressed Expression of PPARγ without Effects on Pref-1 Expression*

1997 • 188 citations

Distinct Stages in Adipogenesis Revealed by Retinoid Inhibition of Differentiation after Induction of PPARγ

1996 • 181 citations

Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice

1996 • 180 citations

p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α

1997 • 174 citations

Activation of Peroxisome Proliferator-activated Receptor γ Bypasses the Function of the Retinoblastoma Protein in Adipocyte Differentiation

1999 • 143 citations

Effect of the Pro12Ala Variant of the Human Peroxisome Proliferator-Activated Receptor γ2 Gene on Adiposity, Fat Distribution, and Insulin Sensitivity in Japanese Men

1998 • 135 citations

PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

1998 • 134 citations

Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice

1997 • 124 citations

p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes.

1993 • 120 citations

Acyl‐CoA synthetase mRNA expression is controlled by fibric‐acid derivatives, feeding and liver proliferation

1993 • 108 citations

Differential Expression of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Its Coactivators Steroid Receptor Coactivator-1 and PPAR-Binding Protein PBP in the Brown Fat, Urinary Bladder, Colon, and Breast of the Mouse

1998 • 99 citations

Depot-specific differences in adipose tissue gene expression in lean and obese subjects

1998 • 93 citations

Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice

1997 • 88 citations

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1992 • 81 citations

SUG1, a Putative Transcriptional Mediator and Subunit of the PA700 Proteasome Regulatory Complex, Is a DNA Helicase

1997 • 79 citations

Expression and Hormonal Regulation of Coactivator and Corepressor Genes

1998 • 76 citations

Altered properties of high density lipoprotein subfractions in obese subjects

1997 • 51 citations

Nuclear Receptors Have Distinct Affinities for Coactivators: Characterization by Fluorescence Resonance Energy Transfer

1998 • 49 citations

Lipoprotein profile characterization of the KKA(y) mouse, a rodent model of type II diabetes, before and after treatment with the insulin-sensitizing agent pioglitazone.

1993 • 49 citations

PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects

1997 • 25 citations

Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients

1996 • 17 citations

Non-insulin dependent diabetes and reverse cholesterol transport

1996 • 2 citations