Combined intraarterial 5‐fluorouracil and subcutaneous interferon‐α therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches

Toxicity and response criteria of the Eastern Cooperative Oncology Group

1982 • 10,605 citations

A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients

1998 • 1,210 citations

Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review.

1990 • 351 citations

Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule.

1999 • 317 citations

Enhancement by Interferon of the Specific Cytotoxicity of Sensitized Lymphocytes

1972 • 308 citations

Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma.

1999 • 279 citations

Randomized controlled trial of interferon treatment for advanced hepatocellular carcinoma

2000 • 275 citations

Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration.

1998 • 270 citations

Recombinant interferon-α in inoperable hepatocellular carcinoma: A randomized controlled trial

1993 • 224 citations

The safety and efficacy of transcatheter arterial chemoembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. A prospective controlled study.

1997 • 218 citations

Spontaneous Cell-Mediated Cytotoxicity in Humans: Role of Interferon and Immunoglobulins

1978 • 213 citations

The safety and efficacy of transcatheter arterial chemoembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction

1997 • 187 citations

Non‐surgical treatment of hepatocellular carcinoma

1997 • 176 citations

Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence

1999 • 160 citations

Molecular mechanisms underlying interferon-α-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins

1999 • 143 citations

Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines

1999 • 139 citations

Combined therapy consisting of intraarterial cisplatin infusion and systemic interferon-? for hepatocellular carcinoma patients with major portal vein thrombosis or distant metastasis

2000 • 138 citations

A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein

1997 • 129 citations

Treatment of Cancer of the Liver

1988 • 128 citations

Stimulation of 5-fluorouracil metabolic activation by interferon-α in human colon carcinoma cells

1992 • 127 citations

Interferon effects upon fluorouracil metabolism by HL-60 cells

1989 • 121 citations

Inhibition of angiogenesis.

1992 • 116 citations

Clinical Pilot Study of Intrahepatic Arterial Chemotherapy with Methotrexate, 5-Fluorouracil, Cisplatin and Subcutaneous Interferon-Alpha-2b for Patients with Locally Advanced Hepatocellular Carcinoma

1997 • 99 citations

Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells.

2000 • 91 citations

Intrahepatic chemotherapy for unresectable hepatocellular carcinoma

1988 • 84 citations

Hepatocellular Carcinoma with Portal Tumor Thrombus: Analysis of Factors Determining Prognosis

1993 • 79 citations

The Efficacy of Continuous Local Arterial Infusion of 5-Fluorouracil and Cisplatin through an Implanted Reservoir for Severe Advanced Hepatocellular Carcinoma

1995 • 78 citations

Low serum alpha-fetoprotein level in patients with hepatocellular carcinoma as a predictor of response to 5-fu and interferon-alpha-2b

1993 • 77 citations

Treatment of hepatocellular carcinoma with recombinant leucocyte interferon: A pilot study

1985 • 61 citations

Hepatocellular carcinoma with portal vein tumor thrombus: embolization of arterioportal shunts.

1997 • 61 citations

Implications of surgical treatment for advanced hepatocellular carcinoma with tumor thrombi in the portal vein.

1996 • 60 citations

A prospective trial of recombinant human interferon alpha 2B in previously untreated patients with hepatocellular carcinoma

1990 • 55 citations

Clinical efficacy of portal vein stent placement in patients with hepatocellular carcinoma invading the main portal vein

1999 • 53 citations

Liver resection for hepatocellular carcinoma (HCC) with direct removal of tumor thrombi in the main portal vein

1992 • 48 citations

Hepatic resection with tumor thrombectomy for hepatocellular carcinoma with tumor thrombi in the major vasculatures.

1999 • 47 citations

Intra-arterial and Intravenous Use of 4′ Epidoxorubicin Combined with 5-Fluorouracil in Primary Hepatocellular Carcinoma

1992 • 43 citations

Combined doxorubicin and alpha-interferon therapy of advanced hepatocellular carcinoma

1993 • 41 citations

Study of repeated arterial infusion chemotherapy with a subcutaneously implanted reservoir for advanced hepatocellular carcinoma

1995 • 34 citations

Advanced hepatocellular carcinoma with distant metastases, successfully treated by a combination therapy of α‐interferon and oral tegafur/uracil

2000 • 33 citations

Expression of interferon alpha/beta receptor in human hepatocellular carcinoma.

2000 • 32 citations

Extension of surgical indication for advanced hepatocellular carcinoma: is it possible to prolong life span or improve quality of life?

1996 • 30 citations

Transcatheter arterial embolization for hepatocellular carcinoma with portal vein thrombosis

1995 • 27 citations

Clinical, serologic, and immunologic effects of human leukocyte interferon in HBsAg-positive primary hepatocellular carcinoma

1985 • 27 citations

Recombinant leukocyte a interferon with doxorubicin.A phase I study in advanced solid neoplasms and implications for hepatocellular carcinoma

1988 • 20 citations

Development of portal vein invasion and its outcome in hepatocellular carcinoma treated by transcatheter arterial chemo‐embolization

1994 • 20 citations

A Phase II Trial of Recombinant Leukocyte Interferon Plus Doxorubicin in Patients with Hepatocellular Carcinoma

1994 • 18 citations

Synergetic Effects of Retrovirus IFN-alpha Gene Transfer and 5-FU on Apoptosis of Colon Cancer Cells

1999 • 18 citations

Viral serostatus and coexisting inflammatory activity affect metachronous carcinogenesis after hepatectomy for hepatocellular carcinoma. A further report

2000 • 17 citations

Combination therapy with 5-fluorouracil and IFN-alpha2a induces a nonrandom increase in DNA fragments of less than 3 megabases in HT29 colon carcinoma cells.

1997 • 17 citations