Neurochemical Aspects of Addiction: Opioids and Other Drugs of Abuse

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

[Drug addiction and drug abuse].

1969 • 1,466 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Problems of Drug Dependence

1969 • 970 citations

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

1988 • 913 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain

1986 • 742 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

1987 • 529 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning

1985 • 516 citations

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

1982 • 509 citations

Drug reinforcement studied by the use of place conditioning in rat

1982 • 482 citations

Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration

1979 • 460 citations

The role of reward pathways in the development of drug dependence

1987 • 439 citations

[3H]U-69593 a highly selective ligand for the opioid κ receptor

1985 • 439 citations

The Classification of Dopamine Receptors: Relationship to Radioligand Binding

1983 • 392 citations

Dopaminergic substrates of amphetamine-induced place preference conditioning

1982 • 381 citations

Heroin Addiction—A Metabolic Disease

1967 • 338 citations

Reinforcing effects of morphine microinjection into the ventral tegmental area

1980 • 334 citations

Reinforcing properties of morphine and naloxone revealed by conditioned place preferences: a procedural examination

1984 • 307 citations

Drugs and Reinforcement Mechanisms: A Critical Review of the Catecholamine Theory

1978 • 293 citations

The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat

1987 • 281 citations

Anatomically Distinct Opiate Receptor Fields Mediate Reward and Physical Dependence

1984 • 265 citations

Reinforcing effects of morphine in the nucleus accumbens

1982 • 254 citations

Activation of hypothalamic β-endorphin pools by reward induced by highly palatable food

1983 • 245 citations

Reinforcing effects of brain microinjections of morphine revealed by conditioned place preference

1982 • 238 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Endorphins in Mental Health Research

1979 • 222 citations

Aversive conditioning by psychoactive drugs: Effects of morphine, alcohol and chlordiazepoxide

1973 • 210 citations

Action of drugs of abuse on brain reward systems: An update with specific attention to opiates

1982 • 194 citations

Opioid Peptide Processing and Receptor Selectivity

1986 • 189 citations

Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of μ- and κ-opioid agonists

1987 • 189 citations

Endorphins: Naloxone Fails to Alter Experimental Pain or Mood in Humans

1978 • 184 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine as measured by place conditioning

1985 • 180 citations

Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

1987 • 169 citations

Distribution of active and inactive forms of endorphins in rat pituitary and brain.

1979 • 168 citations

Motivational properties of opioids: evidence that an activation of σ-receptors mediates reinforcement processes

1987 • 167 citations

Opposite motivational effects of endogenous opioids in brain and periphery

1985 • 166 citations

Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists

1988 • 156 citations

Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects.

1977 • 152 citations

Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.

1987 • 151 citations

POSSIBLE ANTIDEPRESSIVE EFFECTS OF OPIOIDS: ACTION OF BUPRENORPHINE

1982 • 149 citations

Pharmacological characterization of the epsilon-opiate receptor.

1981 • 133 citations

Aversive effects of naltrexone in subjects not dependent on opiates

1981 • 131 citations

Opioid regulation of CNS dopaminergic pathways: A review of methodology, receptor types, regional variations and species differences

1983 • 131 citations

Rewarding properties of β-endorphin as measured by conditioned place preference

1987 • 123 citations

Intrinsic regulatory systems of the brain

1986 • 120 citations

Dopaminergic substrates of cocaine-induced place conditioning

1986 • 116 citations

Sites of action of morphine involved in the development of physical dependence in rats

1976 • 112 citations

Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat

1987 • 108 citations

The Origins of Depression: Current Concepts and Approaches

1983 • 106 citations

Dependence creating properties of lipotropin C-fragment (β-endorphin): Evidence for its internal control of behavior

1979 • 102 citations

Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement.

1986 • 101 citations

The use of [³H]‐[<scp>d</scp>‐Pen²,<scp>d</scp>‐Pen⁵]enkephalin as a highly selective ligand for the δ‐binding site

1985 • 99 citations

The case for multiple opiate receptors

1984 • 96 citations

Endorphinergic modulation of neural reward systems indicated by behavioral changes

1984 • 94 citations

Neuroanatomical Correlates of Morphine Dependence

1972 • 94 citations

Ventral tegmental site of opiate reward: Antagonism by a hydrophilic opiate receptor blocker

1983 • 91 citations

Naltrexone-induced dysphoria in former opioid addicts

1985 • 91 citations

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.

1984 • 90 citations

Morphine and codeine from mammalian brain.

1986 • 89 citations

Norbinaltorphimine: Antagonist profile at κ opioid receptors

1987 • 88 citations

Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central ?-endorphin

1985 • 88 citations

Opioid receptor subtypes associated with ventral tegmental facilitation of lateral hypothalamic brain stimulation reward

1987 • 84 citations

Stereospecific aversive property of narcotic antagonists in morphine-free rats

1978 • 81 citations

Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

1986 • 80 citations

The dopamine hypothesis of opiate reward challenged

1987 • 77 citations

The Many Possible Roles of Opioids and Related Peptides in Stress‐Induced Analgesia^a

1986 • 75 citations

Kappa receptors mediate the peripheral aversive effects of opiates

1987 • 74 citations

Neural substrates of opiate reinforcement

1983 • 71 citations

Accelerated development of tolerance during repeated cycles of ethanol exposure

1978 • 61 citations

Highly specific opiate receptors for dynorphin-(1–13) in the mouse vas deferens

1980 • 60 citations

A role for the mesolimbic dopamine system in the reinforcing properties of diazepam

1988 • 60 citations

Aversive property of opioid receptor blockade in drug-naive mice

1987 • 59 citations

Autoradiography of [3H]β-endorphin binding in brain

1983 • 58 citations

Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia.

1985 • 57 citations

Morphine dependence in rats: Secondary reinforcement from environmental stimuli

1972 • 51 citations

Studies in vivo with ICI 174864 and []enkephalin

1985 • 51 citations

Peripheral receptors mediate the aversive conditioning effects of morphine in the rat

1987 • 51 citations

[3H]-beta-endorphin binding in rat brain

1984 • 47 citations

Naltrexone and dysphoria: A double-blind placebo controlled trial

1987 • 46 citations

Naloxone as a negative reinforcer in rhesus monkeys: effects of dose, schedule, and narcotic regimen.

1975 • 44 citations

Endorphins in psychiatry.

1984 • 44 citations

Negative reinforcing properties of morphine-antagonists in naive rhesus monkeys

1973 • 37 citations

Circling from intracranial morphine applied to the ventral tegmental area in rats

1983 • 36 citations

Effects of Ethanol, Temperature, and Endogenous Regulatory Factors on the Characteristics of Striatal Opiate Receptors

1984 • 36 citations

Naloxone-induced mood and physiologic changes in normal volunteers

1979 • 34 citations

In vitro and in vivo inhibition by lithium of enkephalin binding to opiate receptors in rat brain

1982 • 31 citations

Opioids: past, present and future

1984 • 30 citations

Involvement of β-endorphin and μ-opioid receptors in mediating the aversive effect of lithium in the rat

1988 • 30 citations

Heroin addiction--a metabolic disease

1967 • 27 citations

Evidence that μ-opioid receptors mediate midbrain “stimulation-produced analgesia” in the freely moving rat

1987 • 19 citations

Lesions of the hypothalamic arcuate nucleus modify discrete brain and pituitary pools of dynorphin in addition to β-endorphin in the rat

1984 • 19 citations

Effects of opiate antagonist treatment into either the periaqueductal grey or nucleus accumbens on heroin-induced locomotor activation

1987 • 19 citations

Evidence for the epsilon-type of opioid receptor in the rat vas deferens.

1985 • 19 citations

Opioids and Motivation

1987 • 17 citations

Opioids, past, present and future

1985 • 8 citations

Opioid Systems and the Regulation of Mood: Possible Significance in Depression?

1983 • 8 citations

Der Hercynische Florenbezirk. Grundzüge der Pflanzenverbreitung im mitteldeutschen Berg- und Hügellande vom Harz bis zur Rhön, bis zur Lausitz und dem Böhmer Walde . Von O. Drude. Leipzig, Engelmann. 1902. Pp. xix + 671.

1903 • 2 citations