Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Genomic sequencing.

1984 • 8,343 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

1993 • 551 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

1992 • 327 citations

Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element

1996 • 305 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP.

1990 • 272 citations

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP.

1994 • 266 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage.

1992 • 175 citations

Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.

1992 • 129 citations

Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression.

1994 • 85 citations

Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells

1994 • 40 citations