Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

1998 • 1,472 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Classification of human colorectal adenocarcinoma cell lines.

1976 • 943 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

1996 • 830 citations

The γ ₁ 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase

1997 • 734 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

1995 • 280 citations

An RNA polymerase II elongation factor encoded by the human ELL gene

1996 • 277 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 264 citations

Defects in Yolk Sac Hematopoiesis in Mll-Null Embryos

1997 • 257 citations

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

1997 • 247 citations

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

1998 • 245 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene

1997 • 240 citations

The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX

1998 • 238 citations

The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex.

1995 • 225 citations

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

1994 • 223 citations

AF6q21, a Novel Partner of the MLL Gene in t(6; 11)(q21; q23), Defines a Forkhead Transcriptional Factor Subfamily

1997 • 215 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors.

1996 • 206 citations

11q23 rearrangements in acute leukemia.

1996 • 197 citations

DNA-binding properties of the yeast SWI/SNF complex

1996 • 195 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

Mammalian GADD34, an Apoptosis- and DNA Damage-inducible Gene

1997 • 166 citations

t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDC rel , a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes

1998 • 160 citations

TFG3/TAF30/ANC1, a Component of the Yeast SWI/SNF Complex That Is Similar to the Leukemogenic Proteins ENL and AF-9

1996 • 158 citations

Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1

1996 • 142 citations

The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells

1996 • 141 citations

Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia.

1995 • 140 citations

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

1994 • 132 citations

Ten novel 11q23 chromosomal partner sites

1998 • 131 citations

The ets Family Member Tel Binds to the Fli-1 Oncoprotein and Inhibits Its Transcriptional Activity

1998 • 126 citations

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

1997 • 125 citations

trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each

1993 • 119 citations

Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene

1998 • 108 citations

ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex

1998 • 103 citations

HRX Leukemic Fusion Proteins Form a Heterocomplex with the Leukemia-associated Protein SET and Protein Phosphatase 2A

1997 • 103 citations

Characterisation of the interaction between PCNA and Gadd45.

1995 • 103 citations

The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34

1997 • 97 citations

Interleukin-11 acts as an autocrine growth factor for human megakaryoblastic cell lines

1993 • 94 citations

Subtraction hybridization identifies a transformation progression-associated gene PEG -3 with sequence homology to a growth arrest and DNA damage-inducible gene

1997 • 85 citations

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.

1996 • 71 citations

p53-independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: suppression of apoptosis during the transition from preneoplasia to carcinoma.

1996 • 58 citations

Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.

1996 • 36 citations

Trithorax is required to maintain engrailed expression in a subset of engrailed-expressing cells

1995 • 33 citations

Activation of Extracellular Signal-regulated Kinase 2 by a Novel Abl-binding Protein, ST5

1998 • 31 citations

Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization

1993 • 25 citations

Chromosome abnormalities in leukaemia: the 11q23 paradigm.

1996 • 25 citations

The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations

1997 • 17 citations

Antisense oligodeoxyribonucleotide against the MLL-LTG19 chimeric transcript inhibits cell growth and induces apoptosis in cells of an infantile leukemia cell line carrying the t(11;19) chromosomal translocation.

1998 • 12 citations