Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

2008 • 1,116 citations

A2A adenosine receptor protects tumors from antitumor T cells

2006 • 923 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Adenosine: an endogenous regulator of innate immunity

2003 • 864 citations

Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression

2005 • 752 citations

The equilibrative nucleoside transporter family, SLC29

2004 • 688 citations

Tumor antigen-specific T helper cells in cancer immunity and immunotherapy

2005 • 657 citations

Structure and function of adenosine receptors and their genes

2000 • 562 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Adenosine inhibits IL‐12 and TNF‐α production via adenosine A_2areceptor‐dependent and independent mechanisms

2000 • 488 citations

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

1997 • 479 citations

Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention

2005 • 474 citations

Signalling from adenosine receptors to mitogen-activated protein kinases

2003 • 459 citations

The structure and function of CD26 in the T‐cell immune response

1998 • 423 citations

The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine.

1997 • 419 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

A2A Adenosine Receptor Induction Inhibits IFN-γ Production in Murine CD4+ T Cells

2005 • 366 citations

Regulatory T cells and cancer

2007 • 325 citations

Ecto‐enzyme and signaling functions of lymphocyte CD 7 3

1998 • 322 citations

NK Cells and Cancer

2007 • 298 citations

Positive and negative regulation of T-cell activation through kinases and phosphatases

2003 • 273 citations

Hypoxia-Induced Inhibition of Adenosine Kinase Potentiates Cardiac Adenosine Release

1997 • 257 citations

Interleukin‐10 production by human carcinoma cell lines and its relationship to interleukin‐6 expression

1993 • 245 citations

Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.

1998 • 244 citations

Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells

2003 • 225 citations

Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response.

1996 • 209 citations

Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes.

1991 • 208 citations

A glance at adenosine receptors: novel target for antitumor therapy

2003 • 207 citations

Part I: Vaccines for solid tumours

2004 • 197 citations

Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells

1997 • 188 citations

Expression and function of adenosine receptors in human dendritic cells

2001 • 186 citations

Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade.

2003 • 181 citations

Cyclic AMP as a mediator of prostaglandin E-induced suppression of human natural killer cell activity.

1983 • 177 citations

The role of B7 costimulation in T‐cell immunity

1999 • 174 citations

Adenosine deaminase affects ligand‐induced signalling by interacting with cell surface adenosine receptors

1996 • 169 citations

Gs Protein-Coupled Adenosine Receptor Signaling and Lytic Function of Activated NK Cells

2005 • 163 citations

Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.

1999 • 163 citations

Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo

2005 • 147 citations

Inhibition of Cytokine Production and Cytotoxic Activity of Human Antimelanoma Specific CD8+ and CD4+ T Lymphocytes by Adenosine-Protein Kinase A Type I Signaling

2007 • 129 citations

Expression of A2B adenosine receptors in human lymphocytes: Their role in T cell activation

1999 • 128 citations

Adenosine-Mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells

2006 • 127 citations

Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule.

1995 • 125 citations

Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease

2006 • 124 citations

New insights into adenosine‐receptor‐mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency

2004 • 119 citations

Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model.

2003 • 118 citations

Interleukin 2 Receptor Signaling Regulates the Perforin Gene through Signal Transducer and Activator of Transcription (Stat)5 Activation of Two Enhancers

1999 • 113 citations

Adenosine Acts through A2 Receptors to Inhibit IL-2-Induced Tyrosine Phosphorylation of STAT5 in T Lymphocytes: Role of Cyclic Adenosine 3′,5′-Monophosphate and Phosphatases

2004 • 108 citations

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

2001 • 107 citations

Adenosine A_2BReceptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells

2001 • 104 citations

Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites

2005 • 104 citations

Expression of ecto-5′-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma

2006 • 101 citations

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

2001 • 98 citations

Expression of A₃Adenosine Receptors in Human Lymphocytes: Up-Regulation in T Cell Activation

2004 • 89 citations

Adenosine inhibits the adhesion of anti-CD3-activated killer lymphocytes to adenocarcinoma cells through an A3 receptor.

1994 • 86 citations

Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements

1999 • 83 citations

Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs

2003 • 80 citations

Adenosine acts through an A₃ receptor to prevent the induction of murine anti‐CD3‐activated killer T cells

2002 • 76 citations

Current developments of immunotherapy in the clinic

2004 • 75 citations

A3 adenosine receptor agonist potentiates natural killer cell activity

2003 • 73 citations

Adenosine and other low molecular weight factors released by muscle cells inhibit tumor cell growth.

1998 • 70 citations

The Regulation and Biological Activity of Interleukin 12

1998 • 69 citations

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase‒CD26 interaction

2002 • 66 citations

The role of CD8+ T cells in immune responses to colorectal cancer

2002 • 63 citations

Adenosine stimulation of the proliferation of colorectal carcinoma cell lines

2003 • 57 citations

Adenosine inhibits activation‐induced T cell expression of CD2 and CD28 co‐stimulatory molecules: Role of interleukin‐2 and cyclic AMP signaling pathways

2003 • 55 citations

Adenosine receptors and modulation of natural killer cell activity by purine nucleosides.

1990 • 54 citations

Changes in adenosine and glycogen phosphorylase activity during the cardiac cycle

1980 • 52 citations

5′-Nucleotidase activity and adenosine formation in stimulated, hypoxic and underperfused rat heart

1989 • 51 citations

Purine Metabolites Suppress Proliferation of Human NK Cells Through a Lineage-Specific Purine Receptor

1999 • 48 citations

Adenosine Slows Migration of Dendritic Cells but Does Not Affect Other Aspects of Dendritic Cell Maturation

2003 • 46 citations

Natural CD8 + T-cell responses against MHC class I epitopes of the HER-2/ neu oncoprotein in patients with epithelial tumors

2003 • 46 citations

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase–CD26 interaction

2002 • 44 citations

Adenosine Acts through a Novel Extracellular Receptor to Inhibit Granule Exocytosis by Natural Killer Cells

1997 • 44 citations

Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway

2006 • 41 citations

Adenosine Suppresses α4β7 Integrin-Mediated Adhesion of T Lymphocytes to Colon Adenocarcinoma Cells

2002 • 39 citations

Adenosine Down-Regulates the Surface Expression of Dipeptidyl Peptidase IV on HT-29 Human Colorectal Carcinoma Cells

2004 • 38 citations

Challenges for cancer vaccine development

2006 • 36 citations

Clustered Charged Amino Acids of Human Adenosine Deaminase Comprise a Functional Epitope for Binding the Adenosine Deaminase Complexing Protein CD26/Dipeptidyl Peptidase IV

2002 • 36 citations

Antigen Processing Differences Among APC

1997 • 36 citations

New directions in natural killer cell-based immunotherapy of human cancer

2003 • 35 citations

Transmission Of Signals From The T Lymphocyte Antigen Receptor To The Genes Responsible For Cell Proliferation And Immune Function: The Missing Link

1990 • 34 citations

Induction of the 2B9 antigen/dipeptidyl peptidase IV/CD26 on human natural killer cells by IL‐2, IL‐12 or IL‐15

1997 • 33 citations

Production of prostaglandin E2 by tumor cells in vitro.

1980 • 25 citations

Prevention of hepatocellular carcinoma in mice by IL-2 and B7-1 genes co-transfected liver cancer cell vaccines

2003 • 24 citations

Interleukin-12-dependent activation of human lymphocyte subsets

1998 • 22 citations

Evaluation of adenosine deaminase activity in patients with head and neck cancer

1986 • 20 citations

Alteration of adenosine deaminase levels in peripheral blood lymphocytes of patients with gastric cancer

1985 • 16 citations

Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours

1981 • 15 citations

Molecular and Cell Biology of Adenosine Receptors

2003 • 9 citations

New directions in natural killer cell-based immunotherapy of human cancer

2003 • 3 citations

Adenosine, Tumors, and Immunity

2006 • 2 citations

Adenosine Receptor Pharmacology

2006 • 1 citations