New insights into adenosine‐receptor‐mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency

Signaling to NF-κB

2004 • 3,768 citations

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.

2001 • 2,470 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Adenosine: an endogenous regulator of innate immunity

2003 • 864 citations

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis

2003 • 738 citations

P<scp>hysiological</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponse and</scp>I<scp>nflammatory</scp>T<scp>issue</scp>D<scp>amage by</scp>H<scp>ypoxia</scp>-I<scp>nducible</scp>F<scp>actors and</scp>A<scp>denosine</scp>A_2AR<scp>eceptors</scp>

2004 • 672 citations

Turnover of adenosine in plasma of human and dog blood

1989 • 524 citations

M<scp>olecular</scp>D<scp>efects in</scp>H<scp>uman</scp>S<scp>evere</scp>C<scp>ombined</scp>I<scp>mmunodeficiency and</scp>A<scp>pproaches to</scp>I<scp>mmune</scp>R<scp>econstitution</scp>

2004 • 524 citations

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.

1998 • 453 citations

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells11Abbreviations: cAMP, cyclic adenosine 3′,5′-monophosphate; CHO, Chinese hamster ovary; NBMPR, nitrobenzylthioinosine; and NECA, 5′-N-ethyl carboxamido adenosine.

2001 • 421 citations

Effect of γ-butyrobetaine on fatty liver in juvenile visceral steatosis mice

2001 • 369 citations

Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.

1995 • 217 citations

Adenosine and cAMP are potent inhibitors of the NF‐κB pathway downstream of immunoreceptors

2004 • 186 citations

Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.

1984 • 168 citations

Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.

1999 • 163 citations

Adenosine Deaminase-deficient Mice Generated Using a Two-stage Genetic Engineering Strategy Exhibit a Combined Immunodeficiency

1998 • 159 citations

Cutting Edge: Physiologic Attenuation of Proinflammatory Transcription by the Gs Protein-Coupled A2A Adenosine Receptor In Vivo

2004 • 151 citations

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.

1995 • 146 citations

Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice

2003 • 135 citations

A3 Adenosine Receptor Signaling Contributes to Airway Inflammation and Mucus Production in Adenosine Deaminase-Deficient Mice

2004 • 122 citations

Adenosine Deaminase Deficiency: Genotype-Phenotype Correlations Based on Expressed Activity of 29 Mutant Alleles

1998 • 118 citations

Adenosine–deaminase–deficient mice die perinatally and exhibit liver–cell degeneration, atelectasis and small intestinal cell death

1995 • 117 citations

Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength

2000 • 116 citations

Adenosine Acts through A2 Receptors to Inhibit IL-2-Induced Tyrosine Phosphorylation of STAT5 in T Lymphocytes: Role of Cyclic Adenosine 3′,5′-Monophosphate and Phosphatases

2004 • 108 citations

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

2001 • 107 citations

Adenosine suppresses activation of nuclear factor-κB selectively induced by tumor necrosis factor in different cell types

2003 • 98 citations

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

2001 • 98 citations

The Use of Enzyme Therapy to Regulate the Metabolic and Phenotypic Consequences of Adenosine Deaminase Deficiency in Mice

2000 • 93 citations

Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs

2003 • 80 citations

Identification of A3 Receptor- and Mast Cell-Dependent and -Independent Components of Adenosine-Mediated Airway Responsiveness in Mice

2003 • 68 citations

S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine.

1983 • 63 citations

The role of Rel/NF-κB transcription factors in B lymphocyte survival

2003 • 59 citations

A2A receptor dependent and A2A receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency

2000 • 56 citations

The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase

1999 • 53 citations

From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-κB

2003 • 52 citations

dATP Causes Specific Release of Cytochrome C from Mitochondria

1998 • 47 citations

Impaired Germinal Center Maturation in Adenosine Deaminase Deficiency

2003 • 45 citations

Adenosine kinase inhibition promotes survival of fetal adenosine deaminase–deficient thymocytes by blocking dATP accumulation

2002 • 40 citations

Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase–deficient fetal thymic organ cultures

2000 • 39 citations

Adenosine kinase inhibition promotes survival of fetal adenosine deaminase–deficient thymocytes by blocking dATP accumulation

2002 • 35 citations

A2A receptor dependent and A2A receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency

2000 • 13 citations