Tumor antigen-specific T helper cells in cancer immunity and immunotherapy

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

SYFPEITHI: database for MHC ligands and peptide motifs

1999 • 2,307 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Epitope spreading in immune-mediated diseases: implications for immunotherapy

2002 • 865 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Infectious Tolerance

2002 • 614 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients

2001 • 436 citations

Generation of T-Cell Immunity to the HER-2/neu Protein After Active Immunization With HER-2/neu Peptide–Based Vaccines

2002 • 426 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning.

1994 • 304 citations

Antigen presentation by MHC class I and its regulation by interferon γ

1999 • 287 citations

Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma.

2003 • 257 citations

Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity.

2002 • 233 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Survey of naturally occurring CD4 ⁺ T cell responses against NY-ESO-1 in cancer patients: Correlation with antibody responses

2003 • 201 citations

Neural network-based prediction of candidate T-cell epitopes

1998 • 180 citations

Cutting Edge: CD4+ T Cell Control of CD8+ T Cell Reactivity to a Model Tumor Antigen

2000 • 168 citations

Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell.

2002 • 149 citations

Defining promiscuous MHC class II helper T-cell epitopes for the HER2/neu tumor antigen.

2000 • 137 citations

Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejection.

2002 • 128 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 126 citations

CD4+ T Cells in Adoptive Immunotherapy and the Indirect Mechanism of Tumor Rejection

2000 • 119 citations

Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design.

2002 • 117 citations

Humoral Epitope-Spreading Following Immunization with a HER-2/neu Peptide Based Vaccine in Cancer Patients

2004 • 111 citations

Tumor-infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome

1999 • 107 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 107 citations

Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.

1993 • 104 citations

Cutaneous T Cell Lymphoma Reactive CD4+ Cytotoxic T Lymphocyte Clones Display a Th1 Cytokine Profile and Use a Fas-Independent Pathway for Specific Tumor Cell Lysis

2000 • 104 citations

Direct costimulation of tumor-reactive CTL by helper T cells potentiate their proliferation, survival, and effector function.

2002 • 97 citations

Immunization of cancer patients with HER-2/neu-derived peptides demonstrating high-affinity binding to multiple class II alleles.

2003 • 95 citations

Importance of CD4+ T helper cell responses in tumor immunity

2000 • 93 citations

Therapy with cultured T cells: principles revisited

1997 • 90 citations

Identification of immunodominant regions among promiscuous HLA-DR–restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3

2003 • 90 citations

Autoantibody profiling for the study and treatment of autoimmune disease.

2002 • 88 citations

Th1 and Th2 Cell Clones to a Poorly Immunogenic Tumor Antigen Initiate CD8+ T Cell-Dependent Tumor Eradication In Vivo

2000 • 87 citations

Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancer

1999 • 86 citations

Melanoma‐specific CD4+ T lymphocytes recognize human melanoma antigens processed and presented by epstein‐barr virus‐transformed B cells

1994 • 86 citations

CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells

1996 • 82 citations

HER-2/neu Oncogenic Protein: Issues in Vaccine Development

1998 • 80 citations

Driver Clones and Determinant Spreading

2000 • 79 citations

Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes.

2003 • 76 citations

The use of bioinformatics for identifying class II-restricted T-cell epitopes

2003 • 75 citations

Identifying antigenic T-cell sites

1991 • 68 citations

TAP-Independent Presentation of CTL Epitopes by Trojan Antigens

2001 • 56 citations

CD4(+) T cells from healthy subjects and colon cancer patients recognize a carcinoembryonic antigen-specific immunodominant epitope.

2003 • 53 citations

Characterization of human non-small cell lung cancer (NSCLC) cell lines for expression of MHC, co-stimulatory molecules and tumor-associated antigens

2001 • 52 citations

Evaluation of HLA-DR Expression and T-Lymphocyte Infiltration in Osteosarcoma

1998 • 49 citations

HER-2/neu-derived peptide 884–899 is expressed by human breast, colorectal and pancreatic adenocarcinomas and is recognized by in-vitro-induced specific CD4+ T cell clones

2002 • 48 citations

Targeted therapy of solid malignancies via HLA class II antigens: a new biotherapeutic approach?

2003 • 47 citations

Ii-Key/HER-2/ neu MHC class-II antigenic epitope vaccine peptide for breast cancer

2004 • 44 citations

Effect of recombinant human leukocyte, fibroblast, and immune interferons on expression of class I and II major histocompatibility complex and invariant chain in early passage human melanoma cells.

1990 • 38 citations

The alternative open reading frame of LAGE-1 gives rise to multiple promiscuous HLA-DR-restricted epitopes recognized by T-helper 1-type tumor-reactive CD4+ T cells.

2003 • 38 citations

DIFFERENT PATTERNS OF HLA‐DR ANTIGEN EXPRESSION IN NORMAL EPITHELIUM, HYPERPLASTIC AND NEOPLASTIC MALIGNANT LESIONS OF THE BREAST

1995 • 36 citations

Identification of MHC class II-restricted T-cell epitopes in prostate-specific membrane antigen.

2003 • 34 citations

HLA class II sublocus expression in benign and malignant breast epithelium

1988 • 29 citations

Prognostic significance of T-cell infiltrates, expression of β2-microglobulin and HLA-DR antigens in breast carcinoma

1994 • 21 citations

A consensus strategy for combining HLA-DR binding algorithms

2003 • 20 citations

Deleted Work

1955 • 0 citations