Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Evaluation of secondary structure of proteins from UV circular dichroism spectra using an unsupervised learning neural network

1993 • 998 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

A simple method for the preparation of homogeneous phospholipid vesicles

1977 • 861 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1991 • 531 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

A Molecular Model of Alzheimer Amyloid β-Peptide Fibril Formation

1999 • 354 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Amyloid β Protein Potentiates Ca²⁺ Influx Through L‐Type Voltage‐Sensitive Ca²⁺ Channels: A Possible Involvement of Free Radicals

1997 • 319 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

1997 • 233 citations

Nicotine Inhibits Amyloid Formation by the β-Peptide

1996 • 218 citations

Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein

1996 • 197 citations

Serological analysis of cell surface antigens of malignant human brain tumors

1978 • 191 citations

Nuclear calcium transport and the role of calcium in apoptosis

1994 • 178 citations

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

1992 • 150 citations

Fibrillogenesis of synthetic amyloid-β peptides is dependent on their initial secondary structure

1995 • 148 citations

The conformation of Alzheimer's β peptide determines the rate of amyloid formation and its resistance to proteolysis

1996 • 118 citations

Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor

1990 • 113 citations

Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques

1994 • 98 citations

Solvent effects on beta protein toxicity in vivo

1992 • 85 citations

Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains

1997 • 75 citations

Intracerebral /sB-amyloid(25–35) produces tissue damage: Is it neurotoxic?

1992 • 74 citations

Neurotoxicity of a Carboxyl‐Terminal Fragment of the Alzheimer's Amyloid Precursor Protein

1996 • 68 citations

Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.

1993 • 68 citations

An Etiological Role of Amyloidogenic Carboxyl‐Terminal Fragments of the β‐Amyloid Precursor Protein in Alzheimer's Disease

1997 • 64 citations

Behavioral and Neuropathologic Changes Induced by Central Injection of Carboxyl‐Terminal Fragment of β‐Amyloid Precursor Protein in Mice

1998 • 56 citations

Bacterial expression, purification of full length and carboxyl terminal fragment of alzheimer amyloid precursor protein and their proteolytic processing by thrombin

1994 • 51 citations

Membrane Currents Induced in Xenopus Oocytes by the C‐Terminal Fragment of the β‐Amyloid Precursor Protein

1996 • 48 citations

Selective neurotoxicity of COOH-terminal fragments of the β-amyloid precursor protein

1993 • 43 citations

Abnormal and deficient processing of β-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cells

1991 • 42 citations

Na+/Ca2+ exchange activity is increased in Alzheimer's disease brain tissues

1991 • 42 citations

Expression of a carboxy-terminal region of the β-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity

1992 • 39 citations

Conformations of synthetic β peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells

1996 • 28 citations

C-terminal fragment of Alzheimerʼs amyloid precursor protein inhibits sodium/calcium exchanger activity in SK-N-SH cell

1999 • 28 citations

Cation selective channels formed by a C-terminal fragment of β-amyloid precursor protein

1999 • 25 citations

Peptide Fragments of β‐Amyloid Precursor Protein: Effects on Parallel Fiber‐Purkinje Cell Synaptic Transmission in Rat Cerebellum

2000 • 22 citations

C-terminal fragment of amyloid precursor protein inhibits calcium uptake into rat brain microsomes by Mg2+-Ca2+ ATPase

1998 • 20 citations

Secretory cleavage site of Alzheimer amyloid precursor protein is heterogeneous in Down's syndrome brain

1994 • 20 citations