The conformation of Alzheimer's β peptide determines the rate of amyloid formation and its resistance to proteolysis

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 735 citations

Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease

1992 • 618 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1991 • 531 citations

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

1987 • 475 citations

Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding

1988 • 463 citations

Analysis of the circular dichroism spectrum of proteins using the convex constraint algorithm: A practical guide

1992 • 436 citations

Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.

1995 • 418 citations

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease βA4 peptides

1992 • 406 citations

Folding of peptide fragments comprising the complete sequence of proteins

1992 • 391 citations

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

1994 • 363 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

The α-Helical to β-Strand Transition in the Amino-terminal Fragment of the Amyloid β-Peptide Modulates Amyloid Formation

1995 • 319 citations

MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE

1989 • 266 citations

Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.

1992 • 265 citations

Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E

1995 • 255 citations

In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to alzheimer's disease β-protein

1986 • 226 citations

Effects of Sulfate Ions on Alzheimer β/A4 Peptide Assemblies: Implications for Amyloid Fibril‐Proteoglycan Interactions

1992 • 211 citations

Modeling studies of the change in conformation required for cleavage of limited proteolytic sites

1994 • 204 citations

Kinetic analysis of amyloid fibril polymerization in vitro.

1991 • 190 citations

NMR studies of amyloid .beta.-peptides: proton assignments, secondary structure, and mechanism of an .alpha.-helix .fwdarw. .beta.-sheet conversion for a homologous, 28-residue, N-terminal fragment

1992 • 184 citations

Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic xray diffraction pattern

1987 • 154 citations

Structural Determinants of the Alzheimer's Amyloid β‐Peptide

1994 • 154 citations

Proton NMR studies of the solution conformations of an analog of the C-peptide of ribonuclease A

1989 • 154 citations

Conformation and Fibrillogenesis of Alzheimer Aβ Peptides with Selected Substitution of Charged Residues

1994 • 152 citations

Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.

1994 • 151 citations

Fibrillogenesis of synthetic amyloid-β peptides is dependent on their initial secondary structure

1995 • 148 citations

Reversible Random Coil-.beta.-Sheet Transition of the Alzheimer .beta.-Amyloid Fragment (25-35)

1994 • 148 citations

Solution Structure of Residues 1-28 of the Amyloid .beta.-Peptide

1994 • 144 citations

An interaction of β‐amyloid with aluminium in vitro

1993 • 128 citations

Formation and Structure of Gels and Fibrils from Glucagon

1969 • 121 citations

β-amyloid peptide in vitro toxicity: Lot-to-lot variability

1992 • 116 citations

Alzheimer's disease and soluble Aβ

1994 • 110 citations

The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.

1994 • 99 citations

Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid β/A4 peptide

1993 • 83 citations

Two conformational states of amyloid β-peptide: implications for the pathogenesis of Alzheimer's disease

1995 • 59 citations

Comparative Analysis of Human and Dutch-Type Alzheimer β-Amyloid Peptides by Infrared Spectroscopy and Circular Dichroism

1993 • 57 citations

Amyloid P Component Promotes Aggregation of Alzheimer′s β-Amyloid Peptide

1995 • 51 citations

Structure determination of extracellular fragments of amyloid proteins involved in Alzheimer's disease and Dutch‐type hereditary cerebral haemorrhage with amyloidosis

1994 • 50 citations

Toxicity of synthetic aβ peptides and modeling of alzheimer's disease

1992 • 40 citations