Camptothecins: from bench research to hospital wards.

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Supercoiling of the DNA template during transcription.

1987 • 1,909 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1989 • 533 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1989 • 445 citations

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

1992 • 438 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

1989 • 406 citations

Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.

1993 • 392 citations

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer.

1992 • 384 citations

DNA topoisomerases: why so many?

1991 • 375 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Phase I and pharmacokinetic trial of weekly CPT-11.

1993 • 300 citations

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

1990 • 292 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

1988 • 260 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

1980 • 232 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

Effects of CPT‐11 in combination with other anti‐cancer agents in culture

1992 • 226 citations

Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.

1990 • 226 citations

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

1991 • 221 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

1992 • 212 citations

DNA topoisomerases from rat liver: physiological variations

1983 • 206 citations

Action of camptothecin on mammalian cells in culture.

1972 • 190 citations

Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin.

1991 • 179 citations

A model for tumor cell killing by topoisomerase poisons.

1990 • 172 citations

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

1989 • 172 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice

1991 • 163 citations

Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.

1988 • 162 citations

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.

1991 • 159 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864).

1991 • 154 citations

Studies on camptothecin. I. Effects of nucleic acid and protein synthesis.

1971 • 146 citations

Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

1991 • 144 citations

CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer.

1992 • 144 citations

Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs

1993 • 136 citations

p53 Alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes

1994 • 133 citations

Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia

1993 • 133 citations

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I

1989 • 126 citations

Phase I Study and Pharmacokinetics of CPT-11 With 5-Day Continuous Infusion

1992 • 122 citations

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations

1987 • 113 citations

Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells

1992 • 109 citations

Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin

1971 • 109 citations

Potentiation of radiation response in human carcinoma cells in vitro and murine fibrosarcoma in vivo by topotecan, an inhibitor of DNA topoisomerase I

1992 • 108 citations

Plant Anticancer Agents X. Isolation of Camptothecin and 9-Methoxycamptothecin From Ervatamia heyneaya

1979 • 105 citations

Genetic Mechanisms of Drug Resistance: A Review

1991 • 103 citations

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

1992 • 100 citations

Liposomal stabilization of camptothecin's lactone ring

1992 • 98 citations

Effects of camptothecin on RNA synthesis in leukemia L1210 cells

1971 • 94 citations

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

1988 • 93 citations

Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes

1991 • 90 citations

Selective Interruption of High Molecular Weight RNA Synthesis in HeLa Cells by Camptothecin

1972 • 87 citations

Camptothecin effects on DNA synthesis in murine leukemia cells

1972 • 87 citations

Additional Members of the Rat Liver Lamin Polypeptide Family

1989 • 84 citations

Plant Anticancer Agents XXI. Constituents ofMerrilliodendron megacarpum*

1981 • 73 citations

Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata decne: total synthesis and biological activity

1986 • 73 citations

[Phase I clinical study of CPT-11. Research group of CPT-11].

1990 • 65 citations

Camptothecin inhibits macromolecular synthesis in mammalian cells but not in isolated mitochondria or lE. coli

1970 • 58 citations

Pharmacokinetics of the 9-amino and 10,11-methylenedioxy derivatives of camptothecin in mice.

1993 • 41 citations

Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cells

1990 • 41 citations

Mechanisms of resistance to topoisomerase inhibitors

1994 • 27 citations

Studies on the Regulation and Specificity of the DNA-untwisting Enzyme

1979 • 20 citations

High dose intensity of CPT-11 administered as single dose every 3 weeks: The instittut gustave roussy experience

1993 • 13 citations

Synthesis and biological activity in the camptothecin series

1973 • 10 citations