Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia

1992 • 461 citations

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

1992 • 438 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

A ubiquitous family of repeated DNA sequences in the human genome

1979 • 420 citations

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.

1992 • 363 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.

1990 • 226 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Camptothecin, teniposide, or 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells.

1991 • 109 citations

Current chemotherapeutic treatment approaches to the management of previously untreated adults with de novo acute myelogenous leukemia.

1987 • 91 citations

The binding of gyrase to DNA: analysis by retention by nitrocellulose filters

1982 • 80 citations

The separation of DNA segments attached to proteins

1979 • 64 citations

Filter-binding assay for covalent DNA-protein complexes: adenovirus DNA-terminal protein complex.

1978 • 57 citations

Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin.

1992 • 50 citations

Cancer of the Testes

2015 • 41 citations

Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.

1992 • 35 citations

Rapid evaluation of topoisomerase inhibitors: Caffeine inhibition of topoisomerases in vivo

1990 • 35 citations

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