β-Amyloid converts an acute phase injury response to chronic injury responses

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Degeneration and Regeneration of the Nervous System.

1929 • 2,924 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

Basic Neurochemistry???Molecular, Cellular, and Medical Aspects

2006 • 1,374 citations

Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

1989 • 1,360 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Cytology & cellular pathology of the nervous system

1965 • 1,037 citations

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

1989 • 904 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

The role of complement in inflammation and phagocytosis

1991 • 495 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs

1995 • 460 citations

Immune System Response in Alzheimer's Disease

1989 • 457 citations

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Macrophages and the Nervous System

1991 • 429 citations

Immunoglobulins and complement factors in senile plaques

1982 • 427 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1992 • 396 citations

Macrophages and inflammation in the central nervous system

1993 • 390 citations

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

1988 • 381 citations

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

1994 • 321 citations

β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

1996 • 305 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Complement activation in amyloid plaques in Alzheimer’s dementia

1988 • 289 citations

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

1995 • 284 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

1991 • 280 citations

Cell Biology of Synaptic Plasticity

1984 • 275 citations

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce ?-amyloid fibrils

1992 • 267 citations

Cytology and Cellular Pathology of the Nervous System.

1932 • 245 citations

Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes

1991 • 245 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines.

1995 • 243 citations

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

1992 • 231 citations

Progress in neuropathology

1971 • 225 citations

Localization and Cell Association of C1q in Alzheimer's Disease Brain

1996 • 216 citations

Chemotaxis by a CNS macrophage, the microglia

1990 • 215 citations

Progress in Neuropathology

1972 • 203 citations

Early association of reactive astrocytes with senile plaques in Alzheimer's disease

1995 • 196 citations

Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors

1992 • 192 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease

1993 • 185 citations

Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation.

1987 • 182 citations

Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning

1992 • 176 citations

Glial fibrillary acidic protein and Alzheimer‐type senile dementia

1980 • 176 citations

TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration

1993 • 174 citations

Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages.

1987 • 165 citations

Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques

1984 • 164 citations

Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes.

1995 • 163 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.

1992 • 158 citations

β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

1994 • 151 citations

Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells

1993 • 138 citations

Identification of Elastase as a Secretory Protease from Cultured Rat Microglia

1992 • 137 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

A special type of senile plaque, possibly an initial stage

1987 • 129 citations

Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis.

1994 • 125 citations

Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

1993 • 122 citations

Characterization of interleukin-1 production by microglia in culture

1992 • 121 citations

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

1992 • 120 citations

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

1990 • 112 citations

DNA binds and activates complement via residues 14-26 of the human C1q A chain.

1992 • 110 citations

Localization of sites through which C-reactive protein binds and activates complement to residues 14-26 and 76-92 of the human C1q A chain.

1992 • 106 citations

Astrocytes and the plaques of Alzheimer's disease

1990 • 105 citations

Stimulation of a human polymorphonuclear leukocyte oxidative response by the C1q subunit of the first complement component.

1982 • 98 citations

Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage

1992 • 87 citations

β-Amyloid peptides induce degeneration of cultured rat microglia

1993 • 82 citations

Neuritic Involvement within bFGf Immunopositive Plaques of Alzheimer's Disease

1993 • 76 citations

Phagocytosis of myelin by microglia in vitro

1993 • 70 citations

Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.

1992 • 67 citations

Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3

1995 • 61 citations

Clq acts synergistically with phorbol dibutyrate to activate CR1‐mediated phagocytosis by human mononuclear phagocytes

1988 • 61 citations

β-Amyloid precursor protein and alzheimer's disease: The peptide plot thickens

1992 • 60 citations

Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG

1991 • 58 citations

Complement proteins and complement inhibitors in Alzheimer's disease

1992 • 57 citations

Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia

1995 • 57 citations

Migration of perivascular cells into the neuropil and their involvement in ?-amyloid plaque formation

1993 • 55 citations

Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state

1994 • 49 citations

Interleukin-1β increases basic fibroblast growth factor mRNA expression in adult rat brain and organotypic hippocampal cultures

1994 • 42 citations

Effects of soluble aggregates of IgG on the binding, uptake and degradation of the Clq subcomponent of complement by adherent guinea pig peritoneal macrophages

1985 • 22 citations

Basic Fibroblast Growth Factor in the Mature Brain and Its Possible Role in Alzheimer's Disease

1991 • 22 citations