Structure of the Hemagglutinin Precursor Cleavage Site, a Determinant of Influenza Pathogenicity and the Origin of the Labile Conformation

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

1981 • 2,490 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Core Structure of gp41 from the HIV Envelope Glycoprotein

1997 • 1,904 citations

Rational design of potent sialidase-based inhibitors of influenza virus replication

1993 • 1,819 citations

Atomic structure of the ectodomain from HIV-1 gp41

1997 • 1,610 citations

Structure of influenza haemagglutinin at the pH of membrane fusion

1994 • 1,546 citations

THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS

1987 • 1,391 citations

Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness

1998 • 1,351 citations

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

1988 • 1,151 citations

Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection.

1994 • 920 citations

A spring-loaded mechanism for the conformational change of influenza hemagglutinin

1993 • 854 citations

Activation of influenza A viruses by trypsin treatment

1975 • 831 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.

1982 • 722 citations

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

1992 • 628 citations

Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide

1975 • 602 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Atomic structure of a thermostable subdomain of HIV-1 gp41

1997 • 521 citations

Host cell proteases controlling virus pathogenicity

1994 • 468 citations

Fusion mutants of the influenza virus hemagglutinin glycoprotein

1985 • 399 citations

Influenza hemagglutinin is spring-loaded by a metastable native conformation

1997 • 395 citations

[33] AMoRe: An automated molecular replacement program package

1997 • 365 citations

Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?

1984 • 326 citations

The Molecular Biology of Influenza Virus Pathogenicity

1988 • 318 citations

Influenza virus a pathogenicity: The pivotal role of hemagglutinin

1987 • 276 citations

Increased viral pathogenicity after insertion of a 28S ribosomal RNA sequence into the haemagglutinin gene of an influenza virus

1989 • 271 citations

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

1991 • 265 citations

Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein.

1992 • 260 citations

Activation of influenza virus by acidic media causes hemolysis and fusion of erythrocytes

1980 • 249 citations

Experimental measurement of the effective dielectric in the hydrophobic core of a protein

1997 • 242 citations

Glycosylation affects cleavage of an H5N2 influenza virus hemagglutinin and regulates virulence.

1987 • 221 citations

[THE STRUCTURE AND FUNCTION].

1964 • 213 citations

Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses

1997 • 207 citations

Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones

1993 • 181 citations

Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity

1992 • 177 citations

Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin

1995 • 170 citations

In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core

1991 • 162 citations

Rapid purification of a cloned gene product by genetic fusion and site-specific proteolysis.

1984 • 159 citations

Studies on the Structure of the Influenza Virus Haemagglutinin at the pH of Membrane Fusion

1988 • 158 citations

A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation.

1995 • 153 citations

Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R

1992 • 149 citations

Mutations at the cleavage site of the hemagglutinin alter the pathogenicity of influenza virus a/chick/penn/83 (H5N2)

1989 • 127 citations

Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor

1994 • 109 citations

Interplay between carbohydrate in the stalk and the length of the connecting peptide determines the cleavability of influenza virus hemagglutinin

1989 • 98 citations

Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity

1997 • 98 citations

Nonhomologous Recombination between the Hemagglutinin Gene and the Nucleoprotein Gene of an Influenza Virus

1994 • 88 citations

The structure of a membrane fusion mutant of the influenza virus haemagglutinin.

1990 • 70 citations

Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones

1989 • 61 citations

The Mechanism of Action of Amantadine and Rimantadine Against Influenza Viruses

1989 • 32 citations

Chapter 11 Fusion Activity of the Hemagglutinin of Influenza Virus

1988 • 18 citations

Experimental measurement of the J-integral

1984 • 16 citations