Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects

Bone: Formation by Autoinduction

1965 • 5,498 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

1992 • 680 citations

THE HEALING OF SEGMENTAL BONE DEFECTS, INDUCED BY RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN (rhBMP-2): A RADIOGRAPHIC, HISTOLOGICAL, AND BIOMECHANICAL STUDY IN RATS

1993 • 653 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

Cytokines and Estrogen in Bone: Anti-Osteoporotic Effects

1993 • 466 citations

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.

1989 • 440 citations

Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation

1989 • 405 citations

Mandibular Reconstruction With a Recombinant Bone-Inducing Factor: Functional, Histologic, and Biomechanical Evaluation

1991 • 358 citations

Murine osteogenic protein (OP-1): High levels of mRNA in kidney

1991 • 184 citations

Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor

1991 • 172 citations

Rapid publication TGF-β1 induces bone closure of skull defects

1991 • 164 citations

Bone Grafts and Bone Substitutes

1994 • 124 citations

Bone Grafts and Bone Substitutes

1993 • 116 citations

Transforming Growth Factor-β2 Enhances the Osteoinductive Activity of a Bovine Bone-Derived Fraction Containing Bone Morphogenetic Protein-2 and 3

1991 • 71 citations

Mechanism of the pleiotropic effects of the short‐ear mutant gene in the mouse

1968 • 70 citations

The development of three manifestations of the short ear gene in the mouse

1942 • 38 citations

Effects of the short ear gene in the mouse on cartilage formation in healing bone fractures

1958 • 36 citations