IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions

Central nervous system control of food intake

2000 • 6,305 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Obesity and insulin resistance

2000 • 3,076 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor

1987 • 1,512 citations

Leptin

2000 • 1,368 citations

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

1999 • 1,254 citations

From Lesions to Leptin

1999 • 1,165 citations

Corticotropin-Releasing Factor-Producing Neurons in the Rat Activated by Interleukin-1

1987 • 1,152 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 946 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

1998 • 802 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

1998 • 761 citations

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

2000 • 713 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

1998 • 604 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

2002 • 513 citations

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

1995 • 470 citations

Leptin actions on food intake and body temperature are mediated by IL-1

1999 • 364 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 347 citations

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

1992 • 335 citations

Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

1996 • 302 citations

IL-1β mediates leptin induction during inflammation

1998 • 301 citations

Role of the central melanocortin system in cachexia.

2001 • 286 citations

Insulin Causes Fatty Acid Transport Protein Translocation and Enhanced Fatty Acid Uptake in Adipocytes

2002 • 248 citations

IL-1 produced and released endogenously within human islets inhibits beta cell function.

1998 • 240 citations

Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide

1994 • 236 citations

Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.

1985 • 235 citations

Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression

2000 • 234 citations

Reversal of Cancer Anorexia by Blockade of Central Melanocortin Receptors in Rats

2001 • 216 citations

Thermal and behavioral effects of lipopolysaccharide and influenza in interleukin-1 beta-deficient mice

1995 • 162 citations

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

2002 • 158 citations

Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations

1996 • 152 citations

Effects of interleukin-1β on sleep are mediated by the type I receptor

1998 • 144 citations

Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms

1994 • 137 citations

Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines

1998 • 137 citations

Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.

1993 • 133 citations

Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro

2002 • 127 citations

Regulation of the Hypothalamic-Pituitary-Adrenocortical System in Mice Deficient for CRH Receptors 1 and 2

2001 • 120 citations

Hyperphagia and Weight Gain after Gold-Thioglucose: Relation to Hypothalamic Neuropeptide Y and Proopiomelanocortin**This work was supported by grants from the Children’s Hospital Research Foundation (to H.T.B.) and the NIH (DK-50110; to C.V.M.).

1998 • 114 citations

Prostaglandin E2 Mediates Inhibition of Insulin Secretion by Interleukin-1β

1999 • 97 citations

Cytokine‐Induced Anorexia: Behavioral, Cellular, and Molecular Mechanisms^a

1998 • 92 citations

Functional characterization of phosphoinositide-specific phospholipase C-beta 1 and -beta 3 in intestinal smooth muscle

1995 • 88 citations

Insulin Secretion and Acetylcholinesterase Activity in Monosodium <i>L</i>-Glutamate-Induced Obese Mice

2000 • 85 citations

Temporal and spatial patterns ofc-fos mRNA induced by intravenous interleukin-1: A cascade of non-neuronal cellular activation at the blood-brain barrier

1998 • 85 citations

Anorexic But Not Pyrogenic Actions of Interleukin‐1 are Modulated by Central Melanocortin‐3/4 Receptors in the Rat

2001 • 85 citations

Interferon‐γ and interleukin‐1β inhibit adipoconversion in cultured rodent preadipocytes

1992 • 78 citations

Antidiabetic effects of interleukin 1.

1989 • 77 citations

The Beta Cell in Autoimmune Diabetes: Many Mechanisms and Pathways of Loss

2000 • 64 citations

Postprandial regulation of blood lipids and adipose tissue lipoprotein lipase in type 2 diabetes patients and healthy control subjects

2003 • 62 citations

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist

1999 • 58 citations

Interleukin-1 and lipid metabolism in the rat

1989 • 56 citations

Vagotomy reduces obesity in MSG-treated rats.

2002 • 47 citations

Central and Peripheral Mechanisms Contribute to the Hypoglycemia Induced by Interleukin‐1^a

1998 • 36 citations

Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity

1993 • 29 citations

Effect of chronic IL-1β infusion on glucose homeostasis and pancreatic insulin secretion

1994 • 19 citations

Diurnal Variation of Heart Rate, Locomotor Activity, and Body Temperature in Interleukin-1.ALPHA./.BETA. Doubly Deficient Mice.

2002 • 12 citations

Central infusion of interleukin-1 receptor antagonist fails to alter feeding and weight gain

2000 • 8 citations