Chemotherapy for squamous cell carcinoma of head and neck: The future is now

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Induction Chemotherapy plus Radiation Compared with Surgery plus Radiation in Patients with Advanced Laryngeal Cancer

1991 • 2,563 citations

Head and Neck Cancer

1993 • 2,263 citations

Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

1995 • 759 citations

Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study.

1992 • 734 citations

Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy

1992 • 695 citations

Cancer of the Head and Neck

1989 • 677 citations

Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 • 664 citations

A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck.

1992 • 617 citations

The incidence of p53 mutations increases with progression of head and neck cancer.

1993 • 602 citations

Clonal Proliferations of Cells Infected with Epstein–Barr Virus in Preinvasive Lesions Related to Nasopharyngeal Carcinoma

1995 • 599 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer.

1993 • 420 citations

Suppression of Retinoic Acid Receptor–β in Premalignant Oral Lesions and Its Up-Regulation by Isotretinoin

1995 • 419 citations

Phase III Trial of Initial Chemotherapy in Stage III or IV Head and Neck Cancers: a Study by the Gruppo di Studio sui Tumori della Testa e del Collo

1994 • 416 citations

Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report of intergroup study 0034

1992 • 414 citations

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer

1994 • 403 citations

Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin

1985 • 392 citations

Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and X rays

1982 • 391 citations

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

1993 • 371 citations

Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors.

1990 • 370 citations

Allelotype of head and neck squamous cell carcinoma.

1994 • 349 citations

Metastatic patterns in squamous cell cancer of the head and neck

1987 • 324 citations

Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.

1994 • 322 citations

Treatment of Advanced Squamous-Cell Carcinoma of the Head and Neck with Alternating Chemotherapy and Radiotherapy

1992 • 305 citations

Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity.

1995 • 287 citations

A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma

1995 • 283 citations

Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis.

1994 • 272 citations

Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine (CABO) versus cisplatin and 5-fluorouracil (CF) versus cisplatin (C) in recurrent or metastatic squamous cell carcinoma of the head and neck

1994 • 271 citations

Taxol sensitizes human astrocytoma cells to radiation.

1992 • 267 citations

Adjuvant chemotherapy for advanced head and neck squamous carcinoma

1987 • 267 citations

PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas.

1994 • 263 citations

Preoperative chemotherapy in advanced resectable head and neck cancer: Final report of the southwest oncology group

1988 • 262 citations

Cisplatin and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck

1984 • 262 citations

Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas

1991 • 258 citations

Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study

1976 • 257 citations

Docetaxel (Taxotere®): An active drug for the treatment of patients with advanced squamous cell carcinoma of the head and neck

1994 • 249 citations

Re-irradiation of recurrent nasopharyngeal carcinoma-treatment techniques and results

1987 • 248 citations

Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus.

1994 • 247 citations

Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial.

1987 • 245 citations

PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma

1994 • 242 citations

Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck.

1982 • 234 citations

Chemotherapy as a substitute for surgery in the treatment of advanced resectable head and neck cancer. A report from the northern California oncology group

1987 • 226 citations

Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer.

1992 • 215 citations

Overview of Combined Modality Therapies for Head and Neck Cancer

1993 • 214 citations

Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region

1994 • 210 citations

Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck. An RTOG study

1987 • 210 citations

Randomized clinical trial of mitomycin c as an adjunct to radiotherapy in head and neck cancer

1989 • 204 citations

An allelotype of squamous carcinoma of the head and neck using microsatellite markers.

1994 • 195 citations

Nasopharyngeal cancer: epidemiology, staging, and treatment.

1994 • 189 citations

Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas

1995 • 180 citations

5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer

1989 • 173 citations

Frequency and Sites of Distant Metastases in Head and Neck Squamous Cell Carcinoma: An Analysis of 101 Cases at Autopsy

1987 • 171 citations

Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy

1988 • 169 citations

A randomized trial of cisplatin (CACP) + 5-fluorouracil (5-FU) infusion and CACP + 5-FU bolus for recurrent and advanced squamous cell carcinoma of the head and neck

1985 • 166 citations

Nasopharyngeal carcinoma: the Epstein-Barr virus association.

1994 • 164 citations

Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients.

1988 • 163 citations

Relationship between fluorouracil systemic exposure and tumor response and patient survival.

1994 • 158 citations

Elapsed treatment days—A critical item for radiotherapy quality control review in head and neck trials: RTOG report

1991 • 156 citations

Nasopharyngeal carcinoma. X. Presence of Epstein‐Barr genomes in separated epithelial cells of tumours in patients from Singapore, Tunisia and Kenya

1975 • 155 citations

High-dose reirradiation of head and neck cancer with curative intent

1994 • 154 citations

Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the Head and Neck Contracts Program.

1990 • 144 citations

Cisplatinum and Bleomycin for advanced or recurrent squamous cell carcinoma of the head and neck: a randomised factorial phase III controlled trial

1985 • 143 citations

Gene mutations in saliva as molecular markers for head and neck squamous cell carcinomas

1994 • 141 citations

Placebo-controlled randomized trial of infusional fluorouracil during standard radiotherapy in locally advanced head and neck cancer.

1994 • 140 citations

Amplification of the int-2 gene in human head and neck squamous cell carcinomas.

1990 • 140 citations

Ifosfamide in the treatment of non-small cell lung cancer.

1989 • 138 citations

A phase II study of Gemcitabine (LY 188011) in patients with advanced squamous cell carcinoma of the head and neck

1994 • 135 citations

Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: Results from two randomized clinical trials

1993 • 134 citations

Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced squamous cell carcinoma of the head and neck: Preliminary report of a randomized trial

1991 • 129 citations

Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer: a phase I-II study.

1989 • 128 citations

Continuous Infusion High-Dose Leucovorin with 5-Fluorouracil and Cisplatin for Untreated Stage IV Carcinoma of the Head and Neck

1990 • 126 citations

A randomised clinical trial to contrast radiotherapy with radiotherapy and methotrexate given synchronously in head and neck cancer

1987 • 118 citations

Induction chemotherapy followed by concomitant chemoradiotherapy for advanced head and neck cancer: impact on the natural history of the disease.

1995 • 114 citations

Combined simultaneous cisplatin/fluorouracil chemotherapy and split course radiation in head and neck cancer.

1989 • 111 citations

A phase III randomised trial of cisplatinum, methotrextate, cisplatinum + methotrexate and cisplatinum + 5-FU in end stage squamous carcinoma of the head and neck

1990 • 107 citations

Recurrence after radiotherapy for glottic carcinoma

1991 • 107 citations

Combined chemotherapy and radiation therapy in advanced inoperable squamous cell carcinoma of the head and neck. The final report of a randomized trial

1991 • 102 citations

A randomized trial of radiation therapy compared to split course radiation therapy combined with mitomycin C and 5 fluorouracil as initial treatment for advanced laryngeal and hypopharyngeal squamous carcinoma

1993 • 101 citations

Favorable Long-Term Survival Following Induction Chemotherapy With Cisplatin, Fluorouracil, and Leucovorin and Concomitant Chemoradiotherapy for Locally Advanced Head and Neck Cancer

1992 • 95 citations

Standard chemotherapy in squamous cell head and neck cancer: what we have learned from randomized trials.

1994 • 94 citations

Randomized trial of neoadjuvant cisplatin and fluorouracil versus carboplatin and fluorouracil in patients with stage IV-M0 head and neck cancer.

1995 • 93 citations

Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines

1989 • 89 citations

Receptors for epidermal growth factor and steroid hormones in primary laryngeal tumors

1991 • 88 citations

In vivo cell kinetics in head and neck squamous cell carcinomas predicts local control and helps guide radiotherapy regimen.

1995 • 85 citations

Resection of pulmonary metastases from squamous carcinoma of the head and neck

1988 • 80 citations

Controversies in the management of laryngeal cancer: results of an international survey of patterns of care

1994 • 80 citations

Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: an Eastern Cooperative Oncology Group pilot study.

1993 • 76 citations

Induction chemotherapy with cis-platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck

1986 • 75 citations

Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer.

1988 • 75 citations

Activation of the autocrine transforming growth factor alpha pathway in human squamous carcinoma cells.

1991 • 74 citations

Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis.

1993 • 71 citations

Phase I and II trial of five-day infused 5-fluorouracil and radiation in advanced cancer of the head and neck.

1984 • 71 citations

Cytogenetic Evidence of the Multistep Origin of Head and Neck Squamous Cell Carcinomas

1992 • 70 citations

Intensified concomitant chemoradiotherapy with and without filgrastim for poor-prognosis head and neck cancer.

1994 • 69 citations

Combined modality therapy of head and neck cancer.

1994 • 69 citations

Concurrent CIS-platinum and radiation with or without surgery for advanced head and neck cancer

1994 • 68 citations

Intensive induction chemotherapy and radiation for organ preservation in patients with advanced resectable head and neck carcinoma.

1994 • 66 citations

Cisplatin, fluorouracil with leucovorin calcium enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: a phase II study.

1989 • 62 citations

High-dose versus low-dose cisplatin in advanced head and neck squamous carcinoma: a randomized study.

1985 • 61 citations

Treatment of recurrent head and neck cancer with 5-fluorouracil, hydroxyurea, and reirradiation

1992 • 61 citations

Phase II trial of cisplatin, fluorouracil, and pure folinic acid for locally advanced head and neck cancer: a pharmacokinetic and clinical survey.

1995 • 60 citations

Randomized Trials of Induction Chemotherapy: A Critical Review

1991 • 60 citations

The management of the clinically positive neck as part of a larynx preservation approach

1993 • 59 citations

Larynx Preservation with Combined Chemotherapy and Radiation Therapy in Advanced Hypopharynx Cancer

1994 • 57 citations

Pharmacodynamics of fluorouracil-based induction chemotherapy in advanced head and neck cancer.

1996 • 56 citations

Chemotherapy for Recurrent and Metastatic Head and Neck Cancer

1991 • 56 citations

Simultaneous chemoradiotherapy as salvage treatment in locoregional recurrences of squamous head and neck cancer

1993 • 55 citations

Long-Term Results After Chemoradiotherapy for Locally Confined Squamous-Cell Head and Neck Cancer

1990 • 53 citations

Interactions of chemotherapy and radiation.

1993 • 49 citations

Molecular biology of head and neck cancer.

1994 • 47 citations

Analysis of Complete Responders after Initial Treatment with Chemotherapy in Head and Neck Cancer

1985 • 46 citations

A review of hypoxic cell radiosensitization

1991 • 45 citations

Preliminary trial of nonrecombinant interferon alpha in recurrent squamous cell carcinoma of the head and neck

1991 • 45 citations

Multicenter phase II study of weekly oral vinorelbine for stage IV non-small-cell lung cancer.

1995 • 44 citations

Final report of a phase II study of chemotherapy with bleomycin, epirubicin, and cisplatin for locally advanced and metastatic/recurrent undifferentiated carcinoma of the nasopharyngeal type.

1995 • 44 citations

Concurrent cisplatin, infusional fluorouracil, and conventionally fractionated radiation therapy in head and neck cancer: dose-limiting mucosal toxicity.

1991 • 38 citations

Salvage surgery of cervical recurrences after neck dissection or radiotherapy

1993 • 36 citations

Tolerance of surgery after radical radiotherapy of carcinoma of the oropharynx

1980 • 31 citations

Alternating Cisplatin-5-Fluorouracil and Radiotherapy in Head and Neck Cancer

1988 • 29 citations

Single-agent paclitaxel and paclitaxel plus ifosfamide in the treatment of head and neck cancer.

1995 • 28 citations

Cisplatin, Fluorouracil, and Leucovorin: Increased Toxicity Without Improved Response in Squamous Cell Head and Neck Cancer

1994 • 27 citations

Dose, fractionation and overall treatment time in radiation therapy — the effects on local control for cancer of the larynx

1994 • 25 citations

Rapidly alternating chemotherapy and hyperfractionated radiotherapy in the management of locally advanced head and neck carcinoma: four-year results of a phase I/II study.

1994 • 24 citations

Pilot Study for the Evaluation of Simultaneous Cisplatin/5-Fluorouracil Infusion and Limited Radiation Therapy in Regionally Recurrent Head and Neck Cancer (EST P-C385)

1994 • 24 citations

The community approach to salvage therapy for advanced head and neck cancer.

1994 • 20 citations

The role of paclitaxel in the treatment of head and neck cancer.

1995 • 20 citations

Combined modalities in the treatment of head and neck cancers.

1995 • 19 citations

Ifosfamide in advanced head and neck cancer. A phase II study of the Rotterdam cooperative head and neck cancer study group

1988 • 18 citations

Chemoprevention of Head and Neck Cancers

2010 • 18 citations

Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancer.

1995 • 15 citations

Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer.

1992 • 15 citations

Novel approaches to selective treatments of human solid tumors: Laboratory and clinical correlation

1993 • 14 citations

Cisplatin, 5-fluorouracil and interferon alpha 2b for recurrent or metastatic head and neck cancer

1994 • 13 citations

Pharmacokinetics and in vitro studies of I-leucovorin.Comparison with the d and d,I-leucovorin

1993 • 12 citations

Fluorouracil Modulation in Head and Neck Cancer

1993 • 7 citations

Results of an rtog phase iii trial (rtog 85-27) comparing radiotherapy plus etanidazole (sr-2508) with radiotherapy alone for locally advanced head and neck carcinomas

1994 • 2 citations