Characterization of Monocyte-Derived Dendritic Cells in Recent-Onset Diabetes Mellitus Type 1

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

1997 • 1,179 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

1998 • 576 citations

Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

2000 • 477 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes.

1996 • 424 citations

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

1994 • 331 citations

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

1998 • 315 citations

Prevention and amelioration of collagen‐induced arthritis by blockade of the CD28 co‐stimulatory pathway: requirement for both B7‐1 and B7‐2

1996 • 244 citations

Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer.

1992 • 224 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.

1998 • 182 citations

Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus

1999 • 160 citations

Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule

1995 • 156 citations

Defective maturation and function of antigen-presenting cells in type 1 diabetes

1995 • 147 citations

Dendritic Cells and Macrophages Are the First and Major Producers of TNF-α in Pancreatic Islets in the Nonobese Diabetic Mouse

1998 • 146 citations

Impaired Yield, Phenotype, and Function of Monocyte-Derived Dendritic Cells in Humans at Risk for Insulin-Dependent Diabetes

1998 • 140 citations

Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment

1998 • 131 citations

Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells

1985 • 111 citations

Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus

1999 • 111 citations

Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets.

1999 • 107 citations

Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats

1989 • 105 citations

Multifactorial inheritance in type 1 diabetes

1995 • 95 citations

Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice

1994 • 84 citations

An Immunohistochemical Study on Organized Lymphoid Cell Infiltrates in Fetal and Neonatal Pancreases: A comparison with similar infiltrates found in the pancreas of a diabetic infant

1993 • 59 citations

Opposing effects of CTLA4-Ig and Anti-CD80 (B7-1) plus Anti-CD86 (B7-2) on experimental allergic encephalomyelitis

1996 • 47 citations

A Role for Macrophages in the Pathogenesis of Type 1 Diabetes

1989 • 46 citations

Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats

1989 • 40 citations

Differential effects of interleukin‐10 on the expression of HLA class II and CD1 molecules induced by granulocyte/macrophage colony‐stimulating factor/interleukin‐4

1995 • 37 citations

Circulating monocytes are activated in newly diagnosed type 1 diabetes mellitus patients

1994 • 33 citations

The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+.

1988 • 32 citations

Impairment of monocyte ?lectin-like? receptor activity in Type 1 (insulin-dependent) diabetic patients

1987 • 25 citations

Monokine-Producing Cells Predominate in the Recruitment Phase of NOD Insulitis while Cells Producing Th1-type Cytokines Characterize the Effector Phase

1997 • 20 citations