Circulating monocytes are activated in newly diagnosed type 1 diabetes mellitus patients

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Cytochemical Identification of Monocytes and Granulocytes

1971 • 2,735 citations

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1990 • 245 citations

Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice

1988 • 232 citations

Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

1989 • 183 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Administration of Silica Particles or Anti-Lyt2 Antibody Prevents β-Cell Destruction in NOD Mice Given Cyclophosphamide

1988 • 156 citations

Low-Dose Streptozocin-Induced Diabetes in Mice: Electron Microscopy Reveals Single-Cell Insulitis Before Diabetes Onset

1988 • 151 citations

Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression

1991 • 130 citations

Evidence for IL-6 production by and effects on the pancreatic beta-cell.

1989 • 121 citations

Preferential Infiltration of Macrophages During Early Stages of Insulitis in Diabetes-Prone BB Rats

1988 • 118 citations

Distinct Macrophage Subpopulations in Pancreas of Prediabetic BB/E Rats: Possible Role for Macrophages in Pathogenesis of IDDM

1988 • 116 citations

Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats

1989 • 105 citations

Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor

1991 • 91 citations

Phagocytotic Activity of Monocytes from Diabetic Patients

1983 • 85 citations

Metabolic Activity of Diabetic Monocytes

1980 • 85 citations

Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light-microscopic and ultrastructural observations of pancreatic islets of Langerhans.

1982 • 76 citations

Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages

1988 • 72 citations

Defective monocyte chemotactic responses in diabetes mellitus

1983 • 69 citations

Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes.

1990 • 62 citations

Monocyte Function in IDDM Patients and Healthy Individuals

1990 • 60 citations

Direct Involvement of Macrophages in Destruction of β-Cells Leading to Development of Diabetes in Virus-Infected Mice

1991 • 54 citations

Administration of silica or monoclonal antibody to Thy-1 prevents low-dose streptozotocin-induced diabetes in mice

1986 • 51 citations

Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats

1990 • 50 citations

MONOCYTE FUNCTIONS IN DIABETES MELLITUS

1982 • 34 citations

Glucose and glutamine metabolism in rat macrophages: enhanced glycolysis and unaltered glutaminolysis in spontaneously diabetic BB rats

1991 • 30 citations

Human monocyte chemotaxis in vitro. Influence of in vitro variables in the filter assay.

1983 • 29 citations

Macrophage-Mediated Islet Cell Cytotoxicity in BB Rats

1989 • 24 citations

Low dose streptozotocin causes stimulation of the immune system and of anti-islet cytotoxicity in mice

1991 • 23 citations

Decreased expression of adhesion molecules on monocytes in recent onset IDDM.

1991 • 21 citations

Diabetes Manifestation in BB Rats Is Preceded by Pan-pancreatic Presence of Activated Inflammatory Macrophages

1992 • 18 citations

Ultrastructural observations on cytotoxic effector cells infiltrating pancreatic islets of low-dose streptozocin treated mice

1992 • 18 citations

Early Macrophage Infiltration in Mice Treated with Low-Dose Streptozocin Decreases Islet Superoxide Dismutase Levels: Prevention by SilicaPretreatment

1991 • 17 citations

EFFECT OF SILICA AND CARRAGEENAN ON THE SURVIVAL OF ISLET ALLOGRAFTS

1980 • 16 citations

Initial role of macrophage in the development of anti-β-cell cellular autoimmunity in multiple low-dose streptozotocin-induced diabetes in mice

1990 • 15 citations

Silica prevents the induction of diabetes with complete Freund's adjuvant and low-dose streptozotocin in rats.

1989 • 7 citations

Reticuloendothelial Hyperphagocytosis Occurs in Streptozotocin-Diabetic Rats: Studies with Colloidal Carbon, Albumin Microaggregates, and Soluble Fibrin Monomers

1982 • 6 citations

Macrophage-Specific Chemotactic Lipid Release by In Vivo Streptozocin-Administered Mouse Islets

1991 • 5 citations

Phagocytic Activity of Blood Cells in Diabetic Risk Probands and Newly Diagnosed Type 1 Diabetics

2009 • 4 citations

A Study of Cell‐mediated Immunity in Type 1 Diabetes Using an Antigen Presentation Assay

1989 • 3 citations

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