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Gene regulation by steroid hormones

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Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

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Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

2000 • 1,411 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

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Reduced levels of hsp90 compromise steroid receptor action in vivo

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CDK-Independent Activation of Estrogen Receptor by Cyclin D1

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A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

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Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

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Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

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Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway

2000 • 461 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

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Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor

1988 • 439 citations

AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor

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Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

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Regulation of epidermal growth factor receptor by estrogen.

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Estrogen Receptor Activation Function 1 Works by Binding p160 Coactivator Proteins

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Estrogen receptors α and β in the rodent mammary gland

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Ligand-independent activation of steroid hormone receptors

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pp90^rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

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Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expression in Vitro and in Vivo

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Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

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Mechanism of estrogen activation of c-myc oncogene expression.

1992 • 300 citations

The IRS-signalling system during insulin and cytokine action

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Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution

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Non-genomic effects of steroids Interactions of steroid molecules with membrane structures and functions

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Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

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Effects of estrogen on global gene expression: identification of novel targets of estrogen action.

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Enhanced Epidermal Growth Factor Receptor Signaling in MCF7 Breast Cancer Cells after Long-Term Culture in the Presence of the Pure Antiestrogen ICI 182,780 (Faslodex)*

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Insulin-Like Growth Factor-ll (IGF-II): A Potential Autocrine/Paracrine Growth Factor for Human Breast Cancer Acting via the IGF-I Receptor

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Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol.

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Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells

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Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

Steroid and related receptors

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Cellular Functions of the Plasma Membrane Estrogen Receptor

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Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival.

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P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

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Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors.

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Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

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Estradiol Hypersensitivity and Mitogen-Activated Protein Kinase Expression in Long-Term Estrogen Deprived Human Breast Cancer Cellsin Vivo¹

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Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer.

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Two Separate Mechanisms for Ligand-Independent Activation of the Estrogen Receptor

1997 • 153 citations

Insulin-like Growth Factor Binding Protein-3 Induces Apoptosis in MCF7 Breast Cancer Cells

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Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth.

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Orphan receptors: in search of a unifying hypothesis for activation.

1992 • 138 citations

Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3.

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Potentiation of Estrogen Receptor Activation Function 1 (AF-1) by Src/JNK through a Serine 118-Independent Pathway

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Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.

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Cell cycle control by steroid hormones.

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Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer

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MEKK1 Activation of Human Estrogen Receptor α and Stimulation of the Agonistic Activity of 4-Hydroxytamoxifen in Endometrial and Ovarian Cancer Cells

2000 • 92 citations

Estradiol Down-Regulates the Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptor Gene and Induces Cathepsin-D in Breast Cancer Cells: A Receptor Saturation Mechanism to Increase the Secretion of Lysosomal Proenzymes

1991 • 90 citations

Modulation of the proliferative response of breast cancer cells to growth factors by oestrogen

1992 • 89 citations

Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells.

1996 • 84 citations

In situ distinction between steroid receptor binding and transactivation at a target gene.

1991 • 82 citations

Divergent Pathways Regulate Ligand-Independent Activation of ERα in SK-N-BE Neuroblastoma and COS-1 Renal Carcinoma Cells

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Igf system components as prognostic markers in breast cancer

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Insulin receptor substrate 1 is a target for the pure antiestrogen ICI 182,780 in breast cancer cells

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Mechanisms of 4-hydroxytamoxifen anti-growth factor activity in breast cancer cells: Alterations of growth factor receptor binding sites and tyrosine kinase activity

1990 • 65 citations

Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family

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Prognostic Significance of Insulin-like Growth Factor-Binding Protein Expression in Axillary Lymph Node-Negative Breast Cancer

1994 • 43 citations

Antiestrogens increase protein tyrosine phosphatase activity in human breast cancer cells.

1994 • 42 citations

Overexpressions of c-fos/jun mRNA and their oncoproteins (Fos/Jun) in the mouse uterus treated with three natural estrogens

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Mannose 6-phosphate/insulin-like growth factor 2 receptor, a bona fide tumor suppressor gene or just a promising candidate?

2000 • 30 citations