HLA-DQ Locus of the Human Leukocyte Antigen Complex and Type 1 Diabetes Mellitus: A HuGE Review

HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantation

1992 • 1,846 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends

1999 • 906 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

A Prospective Study of the Role of Coxsackie B and Other Enterovirus Infections in the Pathogenesis of IDDM

1995 • 423 citations

Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY)

1996 • 416 citations

Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study.

1988 • 387 citations

A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus

1993 • 387 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives

1994 • 360 citations

A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus

1994 • 336 citations

Susceptibility to type I diabetes: HLA-DQ and DR revisited

1996 • 324 citations

Coxsackie B virus infection and onset of childhood diabetes

1995 • 268 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to Type 1 (insulin-dependent) diabetes mellitus

1993 • 213 citations

Maternal Enteroviral Infection During Pregnancy as a Risk Factor for ChildHood IDDM: A Population-Based Case-Control Study

1995 • 213 citations

Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.

1990 • 195 citations

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

1997 • 189 citations

Early Exposure to Cow's Milk and Solid Foods in Infancy, Genetic Predisposition, and Risk of IDDM

1993 • 187 citations

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

1993 • 186 citations

Molecular Basis for HLA-DQ Associations With IDDM

1998 • 173 citations

Lack of Immune Responsiveness to Bovine Serum Albumin in Insulin-Dependent Diabetes

1993 • 163 citations

HLA-Encoded Genetic Predisposition in IDDM: DR4 Subtypes May Be Associated With Different Degrees of Protection

1997 • 150 citations

Sex difference in the incidence of insulin-dependent diabetes mellitus: an analysis of the recent epidemiological data

1997 • 146 citations

Rapid HLA-DQB1 Genotyping for Four Alleles in the Assessment of Risk for IDDM in the Finnish Population

1996 • 138 citations

Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals

1992 • 138 citations

Variation by age group and seasonally at diagnosis of childhood IDDM in Europe

1995 • 132 citations

Antigen recognition by T lymphocytes

1972 • 120 citations

Different contribution of HLA‐DR and ‐DQ genes in susceptibility and resistance to Insulin‐dependent diabetes mellitus (IDDM)

1996 • 112 citations

COMPARISON OF RFLP-DR BETA AND SEROLOGICAL HLA-DR TYPING IN 1500 INDIVIDUALS

1990 • 112 citations

Cow milk and insulin-dependent diabetes mellitus: is there a relationship?

1990 • 110 citations

A fifty-year follow-up of congenital rubella

1992 • 109 citations

The Role of Enteroviral Infections in the Development of IDDM: Limitations of Current Approaches

1997 • 106 citations

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility

1992 • 103 citations

Decline of mumps antibodies in Type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of Type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland

1993 • 101 citations

Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children

1996 • 96 citations

Childhood Diabetes in China: Enormous variation by place and ethnic group

1998 • 96 citations

The case for elimination of cow's milk in early infancy in the prevention of type 1 diabetes: The finnish experience

1993 • 74 citations

HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population

1995 • 71 citations

Antibodies to Glutamic Acid Decarboxylase and P2-C Peptides in Sera From Coxsackie Virus B4-Infected Mice and IDDM Patients

1994 • 71 citations

Cow's milk and type I diabetes: the gut immune system deserves attention

1999 • 67 citations

Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype

1998 • 66 citations

GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives.

1998 • 64 citations

To Be Or Net To Be ASP 57, That Is The Question

1992 • 60 citations

Role of viruses in type I diabetes

1998 • 60 citations

Large‐scale oligonucleotide typing for HLA‐DRB1/3/4 and HLA‐DQB1 is highly accurate, specific, and reliable

1993 • 56 citations

Susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ ? Arg 52 and HLA-DQ ? non-Asp 57 alleles

1992 • 56 citations

Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. Belgian Diabetes Registry.

1995 • 48 citations

DR4 subtypes and their molecular properties in a population‐based study of Swedish childhood diabetes

1996 • 46 citations

Descriptive Epidemiology of IDDM in Hokkaido, Japan: The Childhood IDDM Hokkaido Registry

1998 • 46 citations

Coxsackie B virus infection and β cell autoantibodies in newly diagnosed IDDM adult patients

1998 • 45 citations

The pathology of the endocrine pancreas in type 1 (insulin-dependent) diabetes mellitus

1996 • 42 citations

Regional Differences in the Incidence of Insulin-dependent Diabetes Mellitus among Children in Finland from 1987 to 1991

1997 • 40 citations

Distribution of HLA‐DQA1, ‐DQB1 and DRB1 alleles in black IDDM patients and controls from Zimbabwe

1992 • 40 citations

Onset of Type 1 diabetes mellitus in infancy after enterovirus infections

1998 • 39 citations

Additive Susceptibility to Insulin-Dependent Diabetes Conferred by Hla-Dqb1 and Insulin Genes

1994 • 38 citations

Two-Step Islet Autoantibody Screening for Risk Assessment of Type 1 Diabetes in Relatives

1998 • 35 citations

In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk

1995 • 32 citations

HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

1991 • 32 citations

IDDM susceptibility associated with polymorphisms in the insulin gene region A study of blacks, Caucasians and orientals

1994 • 31 citations

Cellular immune responses to β casein: elevated in but not specific for individuals with Type I diabetes mellitus

1998 • 29 citations

Epidemiology of childhood IDDM in U.S. Virgin Islands from 1979 to 1988: Evidence of an Epidemic in Early 1980s and Variation by Degree of Racial Admixture

1991 • 28 citations

HLA‐DR4 SUBTYPE AND ‐B ALLELES IN DQB1*0302‐POSITIVE HAPLOTYPES ASSOCIATED WITH IDDM

1997 • 27 citations

Serology versus PCR‐SSP in typing for HLA‐DR and HLA‐DQ: a practical evaluation

1995 • 25 citations

Molecular IDDM epidemiology: international studies

1996 • 22 citations

Ethnic Differences in Human Leukocyte Antigen Markers of Susceptibility to IDDM

1994 • 22 citations

Analysis of antibody responses against coxsackie virus B4 Protein 2C and the diabetes autoantigen GAD65

1999 • 22 citations

Molecular Epidemiology of Insulin-dependent Diabetes Mellitus

1997 • 22 citations

A new predictive model for insulin‐dependent diabetes mellitus susceptibility based on combinations of molecular HLA‐DRB1 and HLA‐DQB1 pockets

1999 • 22 citations

Insulin Gene Region Contributes to Genetic Susceptibility to, but May Not to Low Incidence of, Insulin-Dependent Diabetes Mellitus in Japanese

1997 • 20 citations

HLA-DQβl Typing and Non-Asp57 Alleles in the Aborigine Population of Senegal

1995 • 11 citations

Susceptibility alleles at HLA-DRB1, -DQA1, and -DQB1 loci in Ethiopian childhood insulin-dependent diabetes mellitus

1994 • 9 citations

Identification of Genetic Susceptibility loci for Insulin-Dependent Diabetes in sudan

1992 • 4 citations

Deleted Work

1955 • 0 citations

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