In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

HL-A ANTIGENS AND DIABETES MELLITUS

1974 • 802 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Sequence of the human insulin gene

1980 • 553 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

Histocompatibility (HL-A) Antigens, Lymphocytotoxic Antibodies and Tissue Antibodies in Patients with Diabetes Mellitus

1973 • 409 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

1995 • 383 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.

1990 • 332 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

The analysis of several 2× 2 contingency tables

1971 • 260 citations

The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association

1983 • 251 citations

Geographic Patterns of Childhood Insulin-Dependent Diabetes Mellitus

1988 • 234 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

Epidemiology of childhood diabetes mellitus in Finland ? background of a nationwide study of Type 1 (insulin-dependent) diabetes mellitus

1992 • 179 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

Genetic Variation in the Human Insulin Gene

1980 • 145 citations

Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals

1992 • 138 citations

New HLA DNA polymorphisms associated with autoimmune diseases

1986 • 135 citations

Restriction Fragment Length Polymorphism of the Insulin Gene in Diabetes Mellitus

1982 • 135 citations

Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes Epidemiology Research International Group

1988 • 123 citations

Measuring the genetic contribution of a single locus to a multilocus disease

1984 • 108 citations

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population

1994 • 101 citations

Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11

1985 • 100 citations

Localization of a Type I Diabetes Susceptibility Locus to the Variable Tandem Repeat Region Flanking the Insulin Gene

1993 • 86 citations

Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5‘ flanking region of the human insulin gene

1992 • 86 citations

Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region.

1993 • 81 citations

NEW SUSCEPTIBILITY HAPLOTYPE FOR TYPE 1 DIABETES

1989 • 79 citations

The HOXD8 Locus (2q31) is Linked to Type I Diabetes: Interaction with Chromosome 6 and 11 Disease Susceptibility Genes

1995 • 76 citations

Type 1 diabetes and the HLA-D locus

1980 • 68 citations

The genetic predisposition to fibrocalculous pancreatic diabetes

1989 • 61 citations

A variant insulin promoter in non-insulin-dependent diabetes mellitus.

1992 • 44 citations

Direct PCR from CVS and blood lysates for detection of cystic fibrosis and Duchenne muscular dystrophy deletions

1991 • 38 citations

Polymorphism at the 5‘ end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals

1988 • 33 citations

IDDM susceptibility associated with polymorphisms in the insulin gene region A study of blacks, Caucasians and orientals

1994 • 31 citations

HLA haplotypes in Type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus

1992 • 30 citations

Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects

1985 • 28 citations

5′ Insulin Gene Polymorphism Confers Risk to IDDM Independently of HLA Class II Susceptibility

1993 • 26 citations

Autoimmune renal disease and tumour necrosis factor beta gene polymorphism.

1993 • 25 citations

Four pins for four petals

1996 • 22 citations

HLA-DR and the 5′ insulin gene polymorphism in insulin-dependent diabetes

1991 • 15 citations

An analysis of amplified insulin gene products in diabetics of Indian origin.

1991 • 13 citations

Polymorphism in the 5′-flanking region of the insulin gene and its potential relation to cardiovascular disease risk: observations in a biracial community

1989 • 11 citations

DQA1 and DQB1 Heterodimers in Insulin-dependent Diabetes Mellitus: A Genetic-epidemiological Study in Finland

1992 • 6 citations