Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain

Functional rafts in cell membranes

1997 • 9,471 citations

B lymphocytes secrete antigen-presenting vesicles.

1996 • 3,198 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

1998 • 1,153 citations

The Immunological Synapse

2001 • 987 citations

The tetraspanin superfamily: molecular facilitators

1997 • 938 citations

Digenic Retinitis Pigmentosa Due to Mutations at the Unlinked Peripherin/ RDS and ROM1 Loci

1994 • 740 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

2000 • 658 citations

Severely Reduced Female Fertility in CD9-Deficient Mice

2000 • 622 citations

Complexes of tetraspanins with integrins: more than meets the eye

2001 • 595 citations

Tetraspanins

2001 • 554 citations

CD81 (TAPA-1): A MOLECULE INVOLVED IN SIGNAL TRANSDUCTION AND CELL ADHESION IN THE IMMUNE SYSTEM

1998 • 507 citations

Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen

1996 • 494 citations

The gamete fusion process is defective in eggs of Cd9-deficient mice

2000 • 476 citations

The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity

1995 • 469 citations

Functional domains in tetraspanin proteins

2003 • 414 citations

Specific tetraspanin functions

2001 • 380 citations

Integrin associated proteins

1998 • 370 citations

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins.

1990 • 365 citations

Polar residues drive association of polyleucine transmembrane helices

2001 • 347 citations

Transmembrane-4 Superfamily Proteins Associate with Activated Protein Kinase C (PKC) and Link PKC to Specific β1 Integrins

2001 • 335 citations

Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity

2002 • 332 citations

Signalling functions of protein palmitoylation

1998 • 328 citations

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors

2002 • 318 citations

Polar side chains drive the association of model transmembrane peptides

2001 • 315 citations

Highly Stoichiometric, Stable, and Specific Association of Integrin α3β1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration

1998 • 308 citations

Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts

2001 • 300 citations

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

1995 • 298 citations

Characterization of Integrin–Tetraspanin Adhesion Complexes

1999 • 287 citations

Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse.

1991 • 284 citations

Regulation of Endothelial Cell Motility by Complexes of Tetraspan Molecules CD81/TAPA-1 and CD151/PETA-3 with α3β1 Integrin Localized at Endothelial Lateral Junctions

1998 • 274 citations

CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs

2001 • 270 citations

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.

1994 • 266 citations

ADAMs in Fertilization and Development

1996 • 259 citations

Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression.

1988 • 245 citations

Ablation of Uroplakin III Gene Results in Small Urothelial Plaques, Urothelial Leakage, and Vesicoureteral Reflux

2000 • 239 citations

A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation

2000 • 236 citations

Role of Transmembrane 4 Superfamily (Tm4sf) Proteins Cd9 and Cd81 in Muscle Cell Fusion and Myotube Maintenance

1999 • 231 citations

Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice

1997 • 231 citations

The Major CD9 and CD81 Molecular Partner

2001 • 226 citations

Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2

2000 • 226 citations

Palmitoylation of Tetraspanin Proteins: Modulation of CD151 Lateral Interactions, Subcellular Distribution, and Integrin-dependent Cell Morphology

2002 • 221 citations

EWI-2 Is a Major CD9 and CD81 Partner and Member of a Novel Ig Protein Subfamily

2001 • 220 citations

Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation

2002 • 220 citations

Selective tetraspan‒integrin complexes (CD81/α4β1, CD151/α3β1, CD151/α6β1) under conditions disrupting tetraspan interactions

1999 • 218 citations

The Tetraspan Molecule Cd151, a Novel Constituent of Hemidesmosomes, Associates with the Integrin α6β4 and May Regulate the Spatial Organization of Hemidesmosomes

2000 • 218 citations

Permeability properties of the intact mammalian bladder epithelium

1996 • 212 citations

Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes

2001 • 212 citations

Structure of the Tetraspanin Main Extracellular Domain

2001 • 209 citations

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

2000 • 200 citations

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81

1997 • 196 citations

Expression of the Palmitoylation-deficient CD151 Weakens the Association of α3β1 Integrin with the Tetraspanin-enriched Microdomains and Affects Integrin-dependent Signaling

2002 • 195 citations

Localization of the Transmembrane 4 Superfamily (TM4SF) Member PETA-3 (CD151) in Normal Human Tissues: Comparison with CD9, CD63, and α5β1 Integrin

1997 • 190 citations

Dominant and digenic mutations in the peripherin/RDS and ROM1 genes in retinitis pigmentosa.

1997 • 183 citations

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function

1999 • 179 citations

Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent

2000 • 178 citations

Direct Extracellular Contact between Integrin α3β1 and TM4SF Protein CD151

2000 • 178 citations

Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins

1994 • 177 citations

Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase

2000 • 175 citations

Osp/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and β1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes

2001 • 172 citations

Why did the Sperm Cross the Cumulus? To Get to the Oocyte. Functions of the Sperm Surface Proteins PH-20 and Fertilin in Arriving at, and Fusing With, the Egg1

1997 • 171 citations

A Neural Tetraspanin, Encoded by late bloomer , That Facilitates Synapse Formation

1996 • 171 citations

Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice

1997 • 169 citations

PLS1 , a gene encoding a tetraspanin-like protein, is required for penetration of rice leaf by the fungal pathogen Magnaporthe grisea

2001 • 162 citations

The Tetraspanin Cd9 Associates with Transmembrane TGF-α and Regulates TGF-α–Induced Egf Receptor Activation and Cell Proliferation

2000 • 162 citations

Association of the tetraspanin CD151 with the laminin-binding integrinsα3β1, α6β1, α6β4 and α7β1 in cells in culture and in vivo

2002 • 161 citations

Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis

2000 • 160 citations

Functional Analysis of Four Tetraspans, CD9, CD53, CD81, and CD82, Suggests a Common Role in Costimulation, Cell Adhesion, and Migration: Only CD9 Upregulates HB-EGF Activity

1997 • 160 citations

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.

1995 • 158 citations

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

2000 • 158 citations

Tetraspanin CD151 regulates α6β1 integrin adhesion strengthening

2003 • 157 citations

An extracellular site on tetraspanin CD151 determines α3 and α6 integrin–dependent cellular morphology

2002 • 151 citations

Tetraspanins and malignancy

2001 • 149 citations

GM3 Ganglioside Inhibits CD9-Facilitated Haptotactic Cell Motility: Coexpression of GM3 and CD9 Is Essential in the Downregulation of Tumor Cell Motility and Malignancy

2001 • 146 citations

Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

2001 • 145 citations

FPRP, a Major, Highly Stoichiometric, Highly Specific CD81- and CD9-associated Protein

2001 • 141 citations

Cutting Edge: Dynamic Redistribution of Tetraspanin CD81 at the Central Zone of the Immune Synapse in Both T Lymphocytes and APC

2002 • 137 citations

CD19 Is Linked to the Integrin-associated Tetraspans CD9, CD81, and CD82

1998 • 134 citations

Selective Interactions of UPIa and UPIb, Two Members of the Transmembrane 4 Superfamily, with Distinct Single Transmembrane-domained Proteins in Differentiated Urothelial Cells

1995 • 130 citations

Clustering of MHC–peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains

2002 • 129 citations

An immunogenic Mr 23,000 integral membrane protein of Schistosoma mansoni worms that closely resembles a human tumor-associated antigen.

1990 • 128 citations

Disulfide-mediated Oligomerization of Peripherin/Rds and Rom-1 in Photoreceptor Disk Membranes

2000 • 128 citations

Function of the Tetraspanin CD151–α6β1 Integrin Complex during Cellular Morphogenesis

2002 • 127 citations

Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells

1992 • 127 citations

Infertility of CD9-Deficient Mouse Eggs Is Reversed by Mouse CD9, Human CD9, or Mouse CD81; Polyadenylated mRNA Injection Developed for Molecular Analysis of Sperm–Egg Fusion

2002 • 127 citations

Three-dimensional analysis of the 16 nm urothelial plaque particle: luminal surface exposure, preferential head-to-head interaction, and hinge formation

1999 • 123 citations

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion

2002 • 120 citations

Targeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions

2000 • 118 citations

Analysis of the CD151·α3β1 Integrin and CD151·Tetraspanin Interactions by Mutagenesis

2001 • 105 citations

CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils.

1996 • 105 citations

Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition

2001 • 103 citations

Transmembrane-4-superfamily proteins CD151 and CD81 associate with α3β1 integrin, and selectively contribute to α3β1-dependent neurite outgrowth

2000 • 101 citations

CD36 associates with CD9 and integrins on human blood platelets

2001 • 98 citations

CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the α6/β1 integrin and the neural adhesion molecule L1

1996 • 96 citations

Stomatin is a major lipid-raft component of platelet α granules

2002 • 93 citations

Murine CD9 Is the Receptor for Pregnancy-specific Glycoprotein 17

2002 • 92 citations

Increased brain size and glial cell number in CD81‐null mice

2002 • 90 citations

PGRL Is a Major CD81-Associated Protein on Lymphocytes and Distinguishes a New Family of Cell Surface Proteins

2001 • 86 citations

Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle 1 1Edited by W. Baumeister

2002 • 85 citations

Release and Intercellular Transfer of Cell Surface CD81 Via Microparticles

2002 • 82 citations

The tetraspanin superfamily in insects

2000 • 80 citations

The Absence of Tssc6, a Member of the Tetraspanin Superfamily, Does Not Affect Lymphoid Development but Enhances In Vitro T-Cell Proliferative Responses

2002 • 78 citations

Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

1997 • 77 citations

Peripherin/rds Influences Membrane Vesicle Morphology

2000 • 77 citations

KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins†

2001 • 75 citations

Analysis of the Roles of RGD-Binding Integrins, α4/α9 Integrins, α6 Integrins, and CD9 in the Interaction of the Fertilin β (ADAM2) Disintegrin Domain with the Mouse Egg Membrane1

2002 • 75 citations

The Role of the Peripherin/<i>RDS</i> Gene in Retinal Dystrophies

1998 • 73 citations

Structure and membrane topology of TAPA-1

1991 • 71 citations

A Functionally Relevant Conformational Epitope on the CD9 Tetraspanin Depends on the Association with Activated β1Integrin

2002 • 68 citations

Quality control of transmembrane domain assembly in the tetraspanin CD82

2001 • 67 citations

Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse

2002 • 66 citations

Importance of the Major Extracellular Domain of CD9 and the Epidermal Growth Factor (EGF)-like Domain of Heparin-binding EGF-like Growth Factor for Up-regulation of Binding and Activity

2000 • 66 citations

Astrocyte Growth, Reactivity, and the Target of the Antiproliferative Antibody, TAPA

1996 • 65 citations

Identification of a highly specific surface marker of T‐cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily

1995 • 64 citations

Phosphoinositides as Key Regulators of Synaptic Function

2001 • 63 citations

T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck

2003 • 62 citations

CD81 Regulates Neuron-Induced Astrocyte Cell-Cycle Exit

2001 • 57 citations

Tetraspanins and Intercellular Interactions

2001 • 57 citations

Subunit Association and Conformational Flexibility in the Head Subdomain of Human CD81 Large Extracellular Loop

2002 • 56 citations

Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity

1995 • 55 citations

Allergen-Induced Airway Hyperreactivity Is Diminished in CD81-Deficient Mice

2000 • 51 citations

Inhibition of feline immunodeficiency virus infection by CD9 antibody operates after virus entry and is independent of virus tropism.

1997 • 47 citations

c-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors

2002 • 46 citations

IN SEARCH OF HEPATITIS C VIRUS RECEPTOR(S)

2001 • 45 citations

A Novel Rat Tetraspan Protein in Cells of the Oligodendrocyte Lineage

1999 • 44 citations

Analysis of Fertilin α (ADAM1)-mediated Sperm-Egg Cell Adhesion during Fertilization and Identification of an Adhesion-mediating Sequence in the Disintegrin-like Domain

2001 • 43 citations

Cell Surface Monkey CD9 Antigen Is a Coreceptor That Increases Diphtheria Toxin Sensitivity and Diphtheria Toxin Receptor Affinity

2000 • 42 citations

Epitope mapping of anti‐rat CD53 monoclonal antibodies. Implications for the membrane orientation of the Transmembrane 4 Superfamily

1993 • 41 citations

A new class of tetraspanins in fungi

2002 • 40 citations

Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies

2001 • 37 citations

Molecular assembly of CD46 with CD9, alpha3–beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF

2002 • 36 citations

CD9 Amino Acids Critical for Upregulation of Diphtheria Toxin Binding

2001 • 32 citations

Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain

1998 • 32 citations

CD81 and microglial activation in vitro: proliferation, phagocytosis and nitric oxide production

2001 • 29 citations

Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase

2000 • 28 citations

CD9 molecule expressed on stromal cells is involved in osteoclastogenesis

1999 • 28 citations

Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse

2001 • 26 citations

Purification and partial characterization of CD9 antigen of human platelets

1990 • 25 citations

Chinese Hamster Ovary Cell Motility to Fibronectin Is Modulated by the Second Extracellular Loop of CD9

2002 • 24 citations

Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography

2001 • 22 citations

CD9 Expression in Solid Non-neuroepithelial Tumors and Infiltrative Astrocytic Tumors

2002 • 22 citations

Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs

2001 • 21 citations

Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons

1999 • 20 citations

TM4SF2 gene involvement reconsidered in an XLMR family after neuropsychological assessment

2002 • 13 citations

Tetraspanins and Intercellular Interactions

2001 • 12 citations

Tetraspanins expressed in the embryonic chick nervous system

1999 • 12 citations

Genomic structure and promoter analysis of the gene encoding MM3, a member of transmembrane 4 superfamily

1997 • 3 citations