Interferon regulatory factors: growth control and histone gene regulation - it's not just interferon anymore

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

The organization and expression of histone gene families

1981 • 501 citations

THE REGULATION OF HISTONE SYNTHESIS IN THE CELL CYCLE

1991 • 498 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.

1993 • 416 citations

Interferon-induced enzymatic activities and their role in the antiviral state

1979 • 392 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

1988 • 342 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1996 • 326 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

1994 • 288 citations

Human β-interferon gene expression is regulated by an inducible enhancer element

1985 • 283 citations

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells

1985 • 263 citations

Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

1995 • 237 citations

Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies

1996 • 235 citations

Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

1988 • 234 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.

1991 • 218 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element.

1991 • 216 citations

Autocrine β-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation

1986 • 206 citations

Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

1991 • 201 citations

A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

1996 • 197 citations

Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2

1995 • 192 citations

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

1994 • 186 citations

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

1986 • 185 citations

A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.

1987 • 169 citations

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

1994 • 167 citations

Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells.

1990 • 159 citations

Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.

1991 • 155 citations

The structure of the human histone genes: Clustered but not tandemly repeated

1981 • 152 citations

A comprehensive compilation and alignment of histones and histone genes

1989 • 149 citations

The regulation of histone gene expression during the cell cycle

1991 • 149 citations

Endogenous Regulation of Macrophage Proliferative Expansion by Colony-Stimulating Factor-Induced Interferon

1984 • 144 citations

Compilation analysis of histones and histone genes

1986 • 141 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

Protein-DNA Interactions in Vivo Upstream of a Cell Cycle-Regulated Human H4 Histone Gene

1987 • 139 citations

Two levels of regulation of beta-interferon gene expression in human cells.

1983 • 136 citations

Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer

1989 • 135 citations

gamma-Interferon increases expression of class III complement genes C2 and factor B in human monocytes and in murine fibroblasts transfected with human C2 and factor B genes.

1985 • 120 citations

CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F.

1996 • 118 citations

Involvement of acis-element that binds an H2TF-l/NFxB like factor(s) in the virus-induced interferon-β gene expression

1989 • 118 citations

A gene-specific promoter element is required for optimal expression of the histone H1 gene in S-phase.

1988 • 116 citations

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

1994 • 114 citations

Purification of the human histone H4 gene-specific transcription factors H4TF-1 and H4TF-2.

1988 • 113 citations

CCAAT Displacement Protein Competes with Multiple Transcriptional Activators for Binding to Four Sites in the Proximal gp91 Promoter

1996 • 110 citations

Characterization of the human p53 gene promoter.

1989 • 108 citations

Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene.

1988 • 106 citations

Transcriptional activation of the mouse Mx gene by type I interferon.

1986 • 92 citations

The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domain.

1994 • 90 citations

Cell-cycle regulatory sequences in a hamster histone promoter and their interactions with cellular factors

1987 • 89 citations

Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression.

1996 • 87 citations

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.

1991 • 86 citations

Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.

1991 • 83 citations

Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1

1994 • 81 citations

Molecular cloning and structure of the human interleukin-5 gene.

1987 • 81 citations

Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters.

1992 • 80 citations

Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha.

1994 • 78 citations

Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression

1994 • 69 citations

Inducible processing of interferon regulatory factor-2.

1992 • 69 citations

Regulation of histone gene expression

1992 • 67 citations

Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias.

1996 • 67 citations

Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif

1989 • 66 citations

Delineation of a human histone H4 cell cycle element in vivo: the master switch for H4 gene transcription.

1994 • 66 citations

Identification of novel factors that bind to the PRD I region of the human β-interferon promoter

1992 • 64 citations

Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein.

1994 • 64 citations

Interferon Regulatory Factors and TFIIB Cooperatively Regulate Interferon-Responsive Promoter Activity In Vivo and In Vitro

1996 • 62 citations

The Yin and the Yang of mammalian transcription

1992 • 61 citations

Altered binding of human histone gene transcription factors during the shutdown of proliferation and onset of differentiation in HL-60 cells.

1989 • 60 citations

clRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA

1995 • 56 citations

Transcriptional element H4‐site II of cell cycle regulated human H4 histone genes is a multipartite protein/DNA interaction site for factors HiNF‐D, HiNF‐M, and HiNF‐P: Involvement of phosphorylation

1991 • 50 citations

Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain.

1995 • 49 citations

Mouse interferons enhance the accumulation of a human HLA RNA and protein in transfected mouse and hamster cells.

1982 • 46 citations

Molecular Characterization of the Gene for Human Interleukin-1β Converting Enzyme (IL1BC)

1994 • 45 citations

Consistent loss of the D5S89 locus mapping telomeric to the interleukin gene cluster and centromeric to EGR-1 in patients with 5q- chromosome

1994 • 44 citations

Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region.

1994 • 42 citations

Cell cycle controlled histone H1, H3, and H4 genes share unusual arrangements of recognition motifs for HiNF‐D supporting a coordinate promoter binding mechanism

1994 • 41 citations

Cooperative interaction of multiple DNA elements in the human interferon-beta promoter

1987 • 39 citations

The transcription factor interferon regulatory factor-1 is expressed during both early G1 and the G1/S transition in the prolactin-induced lymphocyte cell cycle.

1992 • 37 citations

Regulation of interferon action in human fibroblasts: Transient induction of specific proteins and amplification of the antiviral response by actinomycin D

1981 • 34 citations

Functional Role for Sp1 in the Transcriptional Amplification of a Cell Cycle Regulated Histone H4 Gene

1995 • 27 citations

Cytokine induction of proliferation and expression of CDC2 and cyclin a in FDC‐P1 myeloid hematopoietic progenitor cells: Regulation of ubiquitous and cell cycle‐dependent histone gene transcription factors

1995 • 22 citations

Characterization of TH3, an induction-specific protein interacting with the interferon β promoter

1992 • 17 citations

Control of cell cycle regulated histone genes during proliferation and differentiation.

1996 • 13 citations

Role of a distal promoter element in the S‐phase control of the human H1.2 histone gene transcription

1994 • 11 citations