The cytokine response element of the rat alpha 1-acid glycoprotein gene is a complex of several interacting regulatory sequences.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

1982 • 1,498 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

1988 • 886 citations

A High-Efficiency HeLa Cell Nuclear Transcription Extract

1988 • 612 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Using mini-prep plasmid DNA for sequencing double stranded templates with Sequenase.

1988 • 552 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Induction of rat acute‐phase proteins by interleukin 6 in vivo

1988 • 412 citations

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.

1982 • 410 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Modularity in promoters and enhancers

1989 • 366 citations

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

1987 • 358 citations

Disease-induced Changes in the Plasma Binding of Basic Drugs

1980 • 354 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1

1989 • 247 citations

Stimulation of Hepatic Acute Phase Response by Cytokines and Glucocorticoids^a

1989 • 242 citations

Stimulation of murine hemopoietic colony formation by human IL-6.

1988 • 237 citations

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells.

1987 • 228 citations

Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat, and mouse.

1984 • 225 citations

Acute phase proteins as disease markers.

1987 • 205 citations

Activation of transcription factor IIIC by the adenovirus E1A protein

1988 • 197 citations

The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6.

1989 • 196 citations

Immunosuppression by human plasma alpha 1-acid glycoprotein: importance of the carbohydrate moiety.

1980 • 187 citations

Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.

1987 • 182 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer.

1988 • 180 citations

A Multiple Cytokine- and Second Messenger-Responsive Element in the Enhancer of the Human Interleukin-6 Gene: Similarities with c-fosGene Regulation

1989 • 178 citations

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.

1990 • 177 citations

Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter.

1990 • 176 citations

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

1989 • 172 citations

Potential basis for regulation of the coordinately expressed fibrinogen genes: homology in the 5' flanking regions.

1984 • 148 citations

Two distinct cellular phosphoproteins bind to the c-fos serum response element.

1989 • 140 citations

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions

1984 • 135 citations

Identification of cis-acting sequences responsible for phorbol ester induction of human serum amyloid A gene expression via a nuclear factor kappaB-like transcription factor.

1989 • 134 citations

Hepatic acute phase reaction in vivo and in vitro

1989 • 132 citations

The human haptoglobin gene: transcriptional regulation during development and acute phase induction.

1987 • 128 citations

Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man.

1985 • 121 citations

Hepatocyte-stimulating factor, beta 2 interferon, and interleukin-1 enhance expression of the rat alpha 1-acid glycoprotein gene via a distal upstream regulatory region.

1988 • 120 citations

Structure of the human α₁acid glycoprotein gene: sequence homology with other human acute phase protein genes

1985 • 118 citations

IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.

1989 • 116 citations

Alpha Interferon and Gamma Interferon Stimulate Transcription of a Single Gene through Different Signal Transduction Pathways

1989 • 112 citations

An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene.

1990 • 108 citations

Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells.

1987 • 106 citations

Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene.

1990 • 105 citations

Structure andin vitrotranscription of a human H4 histone gene

1983 • 104 citations

Interleukin-1 and Interleukin-6 Stimulate Acute-Phase Protein Production in Primary Mouse Hepatocytes

1989 • 95 citations

Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells.

1988 • 88 citations

Identification of sequences responsible for acute-phase induction of human C-reactive protein

1988 • 87 citations

Acute phase mediators and glucocorticoids elevate alpha 1-acid glycoprotein gene transcription.

1985 • 86 citations

Rat alpha 1-acid glycoprotein. Gene sequence and regulation by glucocorticoids in transfected L-cells.

1985 • 84 citations

Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters.

1987 • 74 citations

Sequence of human haptoglobin cDNA: evidence that the α and β subunits are coded by the same mRNA

1983 • 72 citations

Localization of DNA Sequences Involved in Dexamethasone-Dependent Expression of the Rat α₁-Acid Glycoprotein Gene

1986 • 66 citations

DNase I Footprinting as an Assay for Mammalian Gene Regulatory Proteins

1987 • 53 citations

Identification and characterization of functional genes encoding the mouse major urinary proteins.

1987 • 25 citations

IL‐6/BSF2 in Normal and Abnormal Regulation of Immune Responses^a

1989 • 25 citations

A 69-base-pair monkey DNA sequence enhances simian virus 40 replication and transcription through multiple motifs

1990 • 8 citations