Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential

Equilibrium Ultracentrifugation of Dilute Solutions^*

1964 • 3,399 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

The Molecular Biology of Axon Guidance

1996 • 3,246 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques

1981 • 845 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Improving biosensor analysis

1999 • 753 citations

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

1996 • 637 citations

Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene.

1986 • 618 citations

Krüppel-associated boxes are potent transcriptional repression domains.

1994 • 612 citations

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

1991 • 566 citations

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

1990 • 554 citations

Protein motifs 5. Zinc fingers.

1995 • 544 citations

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

1996 • 532 citations

Zinc fingers

1995 • 501 citations

Perinuclear localization of chromatin facilitates transcriptional silencing

1998 • 466 citations

Looping versus linking: toward a model for long-distance gene activation

1999 • 465 citations

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

1999 • 433 citations

Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes

1997 • 403 citations

Interaction between an Integral Protein of the Nuclear Envelope Inner Membrane and Human Chromodomain Proteins Homologous to HP1

1996 • 398 citations

Position effect in human genetic disease

1998 • 374 citations

KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing

1999 • 373 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

1991 • 368 citations

Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family

1999 • 352 citations

Domain-specific Interactions of Human HP1-type Chromodomain Proteins and Inner Nuclear Membrane Protein LBR

1997 • 351 citations

The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

1994 • 346 citations

Protein sequence similarity searches using patterns as seeds

1998 • 329 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells

1999 • 327 citations

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

1992 • 318 citations

Heterochromatin Dynamics in Mouse Cells

1999 • 287 citations

A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins

1996 • 278 citations

Transcriptional Repression by RING Finger Protein TIF1 That Interacts with the KRAB Repressor Domain of KOX1

1996 • 277 citations

The Heterochromatin Protein 1 Prevents Telomere Fusions in Drosophila

1998 • 274 citations

A sequence motif found in aDrosophilaheterochromatin protein is conserved in animals and plants

1991 • 273 citations

Mammalian chromodomain proteins: their role in genome organisation and expression

2000 • 271 citations

Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

1998 • 269 citations

The HP1 chromo shadow domain binds a consensus peptide pentamer

2000 • 263 citations

Functional analysis of the chromo domain of HP1.

1995 • 259 citations

The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1

1995 • 236 citations

Unfolding the mysteries of heterochromatin

1998 • 222 citations

Beyond the Nucleosome: Epigenetic Aspects of Position–Effect Variegation in Drosophila

1998 • 221 citations

GAL4 fusion vectors for expression in yeast or mammalian cells

1992 • 213 citations

The hyperthermophile chromosomal protein Sac7d sharply kinks DNA

1998 • 211 citations

INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1

1998 • 208 citations

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

2000 • 196 citations

Identification of a Nonhistone Chromosomal Protein Associated with Heterochromatin in Drosophila melanogaster and Its Gene

1986 • 188 citations

A Chromodomain Protein, Swi6, Performs Imprinting Functions in Fission Yeast during Mitosis and Meiosis

2000 • 184 citations

Chromatin components as part of a putative transcriptional repressing complex

1998 • 179 citations

Structure of the chromatin binding (chromo) domain from mouse modifier protein 1

1997 • 170 citations

TIF1γ, a novel member of the transcriptional intermediary factor 1 family

1999 • 161 citations

Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins

1995 • 157 citations

Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress

1995 • 142 citations

SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation

1997 • 141 citations

The crystal structure of the hyperthermophile chromosomal protein Sso7d bound to DNA

1998 • 139 citations

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner

1999 • 124 citations

Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim‐1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1¹

2000 • 115 citations

Distinct Cytoplasmic and Nuclear Fractions of Drosophila Heterochromatin Protein 1: Their Phosphorylation Levels and Associations with Origin Recognition Complex Proteins

1998 • 114 citations

Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.

1993 • 95 citations

The Nuclear Lamina: Molecular Organization and Interaction with Chromatin

1999 • 95 citations

Transcriptional Repression Mediated by Polycomb Group Proteins and Other Chromatin-associated Repressors Is Selectively Blocked by Insulators

2000 • 77 citations

Phosphorylation of Heterochromatin Protein 1 by Casein Kinase II Is Required for Efficient Heterochromatin Binding inDrosophila

1999 • 73 citations

Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: analysis by analytical ultracentrifugation

1989 • 71 citations

Comparative Analysis of KRAB Zinc Finger Proteins in Rodents and Man: Evidence for Several Evolutionarily Distinct Subfamilies of KRAB Zinc Finger Genes

1999 • 66 citations

Exploring Biomolecular Recognition Using Optical Biosensors

1999 • 66 citations

Human Homolog of Drosophila Heterochromatin-Associated Protein 1 (HP1) Is a DNA-Binding Protein Which Possesses a DNA-Binding Motif with Weak Similarity to That of Human Centromere Protein C (CENP-C)

1996 • 51 citations

Funtional Domain Structure of Human Heterochromatin Protein HP1 Hsa: Involvement of Internal DNA-Building DNA-Binding and C-Terminasl Self-Association Domains in the Formation of Discrete Dots in Interphase Nuclei

1999 • 50 citations

Self-association of chromo domain peptides

1997 • 42 citations

Chromatin complexes as aperiodic microcrystalline arrays that regulate genome organisation and expression

1998 • 25 citations

Original articles Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells

1999 • 2 citations