Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Pathologic Basis of Disease.

1980 • 4,790 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

1998 • 1,382 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

1996 • 723 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors.

1996 • 436 citations

Attenuation of allergic airway inflammation in IL‐4 deficient mice

1994 • 433 citations

Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia

1998 • 404 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Interleukin-4 is required for the induction of lung Th2 mucosal immunity.

1995 • 364 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ)

1997 • 349 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1993 • 313 citations

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

1994 • 312 citations

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

1996 • 309 citations

Modulation of Airway Inflammation by Passive Transfer of Allergen-Specific Th1 and Th2 Cells in a Mouse Model of Asthma

1999 • 273 citations

Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells.

1995 • 235 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice.

1996 • 206 citations

Lymphocyte Activation in Bronchoalveolar Lavage and Peripheral Blood in Atopic Asthma

1992 • 152 citations

Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile.

1996 • 144 citations

Role of intracellular calcium and metabolites in low-frequency fatigue of mouse skeletal muscle

1997 • 125 citations

Eosinophils in the 1990s: New perspectives on their role in health and disease

1994 • 123 citations

Cytokine regulation of secondary lymphoid organ development

1998 • 123 citations

Th2-Induced Eotaxin Expression and Eosinophilia Coexist with Th1 Responses at the Effector Stage of Lung Inflammation

1998 • 120 citations

Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1

1997 • 99 citations

Mechanisms of virus induced exacerbations of asthma

1997 • 97 citations

The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?

1996 • 85 citations

Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones.

1997 • 84 citations

Importance of lnterleukin-4 and lnterleukin-12 in Allergen-Induced Airway Changes in Mice

1995 • 74 citations

Endothelial selectins and alpha4 integrins regulate independent pathways of T lymphocyte recruitment in the pulmonary immune response.

1998 • 53 citations

Lymphocytes mediate TNF-alpha-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice.

1997 • 48 citations

Basic mechanisms of asthma.

1995 • 48 citations

T cells as orchestrators of the asthmatic response.

1997 • 46 citations

Endothelial Selectins and α4 Integrins Regulate Independent Pathways of T Lymphocyte Recruitment in the Pulmonary Immune Response

1998 • 45 citations

The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in C57BL/6 mice.

1996 • 41 citations

The Role of Respiratory Viruses in Asthma

2007 • 39 citations

T-Lymphocyte Dysregulation in Asthma

1994 • 29 citations

Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy subjects.

1996 • 28 citations