T cells as orchestrators of the asthmatic response.

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Bronchial Biopsies in Asthma: An Ultrastructural, Quantitative Study and Correlation with Hyperreactivity

1989 • 973 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

Activation of CD4+ T cells, increased T-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1993 • 593 citations

Interleukin 4 is localized to and released by human mast cells.

1992 • 589 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.

1997 • 416 citations

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.

1996 • 413 citations

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

1994 • 394 citations

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma.

1995 • 355 citations

T LYMPHOCYTE ACTIVATION IN ACUTE SEVERE ASTHMA

1988 • 353 citations

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

1995 • 342 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

Trial of cyclosporin in corticosteroid-dependent chronic severe asthma

1992 • 334 citations

Prednisolone Treatment in Asthma Is Associated with Modulation of Bronchoalveolar Lavage Cell Interleukin-4, Interleukin-5, and Interferon-γ Cytokine Gene Expression

1993 • 307 citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen.

1995 • 291 citations

Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa.

1996 • 266 citations

Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

1993 • 259 citations

Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.

1995 • 258 citations

Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.

1995 • 255 citations

Eosinophils: Biology and Role in Disease

1995 • 245 citations

Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy☆☆☆★★★

1997 • 237 citations

Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product.

1995 • 223 citations

T Cells and Cytokines in Bronchoalveolar Lavage Fluid after Segmental Allergen Provocation in Atopic Asthma

1995 • 220 citations

High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma.

1996 • 220 citations

Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

1994 • 219 citations

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

1992 • 214 citations

Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma.

1996 • 197 citations

Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness.

1993 • 190 citations

Peripheral blood CD4 but not CD8 t-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy.

1995 • 150 citations

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

1992 • 140 citations

Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4⁺ and CD8⁺ T cell lines in atopics asthmatics, and atopic and nonatopic controls

1995 • 116 citations

Treatment of steroid-dependent bronchial asthma with cyclosporin

1995 • 104 citations

Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils

1995 • 86 citations

Bronchial inflammation in occupational asthma due to western red cedar.

1995 • 82 citations

Bronchial biopsies and airway inflammation

1996 • 61 citations

Effect of respiratory and other virus infections on IgE immunoregulation

1986 • 57 citations

Co-expression of CD25 and CD3 in atopic allergy and asthma.

1992 • 53 citations

Allergen Specificity and Endothelial Transmigration of T Cells in Allergic Contact Dermatitis and Atopic Dermatitis Are Associated with the Cutaneous Lymphocyte Antigen

1995 • 51 citations

Analysis of Ig VH region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma.

1995 • 48 citations

L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus.

1995 • 44 citations