Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Experimental pathology of the liver

1931 • 3,113 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Inhibition of cyclin-dependent kinases by p21.

1995 • 999 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3.

1962 • 773 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Regeneration of Mammalian Liver

1963 • 717 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

1995 • 552 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

MyoD-Induced Expression of p21 Inhibits Cyclin-Dependent Kinase Activity upon Myocyte Terminal Differentiation

1995 • 416 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

Absence of WAF1 mutations in a variety of human malignancies

1994 • 390 citations

Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

1991 • 387 citations

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

1993 • 362 citations

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

1995 • 338 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.

1994 • 327 citations

In vivo differentiation of rat liver oval cells into hepatocytes.

1989 • 318 citations

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

1995 • 244 citations

A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

1988 • 239 citations

RNA-RNA interactions in the spliceosome: Unraveling the ties that bind

1994 • 208 citations

Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase

1995 • 188 citations

Human hepatocyte polyploidization kinetics in the course of life cycle

1993 • 155 citations

Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.

1990 • 151 citations

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

1994 • 150 citations

Zonation of metabolism and gene expression in liver

1995 • 141 citations

Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration.

1994 • 135 citations

Hepatocyte differentiation and liver progenitor cells

1990 • 125 citations

Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.

1996 • 114 citations

Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice

1991 • 112 citations

Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1).

1994 • 81 citations

Transcriptional control of the mouse prealbumin (transthyretin) gene: both promoter sequences and a distinct enhancer are cell specific.

1986 • 80 citations

The function(s) of CAK, the p34cdc2-activating kinase

1994 • 76 citations

Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration.

1992 • 74 citations

Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant.

1993 • 55 citations

Immunoprecipitation and Immunoblotting in Cell Cycle Studies

1996 • 26 citations

Primary Rat Hepatocytes Express Cyclin D1 Messenger RNA During Their Growth Cycle and During Mitogenic Transitions Induced by Transforming Growth Factor-α

1994 • 8 citations