Long-term synaptic depression in the mammalian brain

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus

1992 • 1,088 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells

1982 • 940 citations

Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex

1990 • 893 citations

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

1993 • 893 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

1988 • 830 citations

Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation

1993 • 780 citations

Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus

1983 • 773 citations

Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons

1990 • 755 citations

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

1993 • 736 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Long-term synaptic depression in the striatum: physiological and pharmacological characterization

1992 • 667 citations

Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

1977 • 606 citations

Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus

1993 • 590 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Persistent protein kinase activity underlying long-term potentiation

1988 • 557 citations

Cellular localization of a metabotropic glutamate receptor in rat brain

1992 • 539 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1993 • 507 citations

Specific long-lasting potentiation of synaptic transmission in hippocampal slices

1977 • 493 citations

Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in Vitro

1993 • 485 citations

Long‐term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency.

1978 • 470 citations

Associative long-term depression in the hippocampus induced by hebbian covariance

1989 • 470 citations

Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells

1992 • 423 citations

NMDA application potentiates synaptic transmission in the hippocampus

1988 • 421 citations

Long‐term Potentiation in the Striatum is Unmasked by Removing the Voltage‐dependent Magnesium Block of NMDA Receptor Channels

1992 • 408 citations

A long-term depression of AMPA currents in cultured cerebellar purkinje neurons

1991 • 405 citations

The spread of Na+ spikes determines the pattern of dendritic Ca2+ entry into hippocampal neurons

1992 • 400 citations

Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy

1987 • 375 citations

Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells.

1992 • 358 citations

Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices

1991 • 356 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal slice

1975 • 340 citations

Participation of Postsynaptic PKC in Cerebellar Long-Term Depression in Culture

1991 • 340 citations

Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus

1991 • 319 citations

The effects of repetitive low frequency stimulation on control and “potentiated” synaptic responses in the hippocampus

1980 • 315 citations

NMDA-Receptor-Independent Long-Term Potentiation

1992 • 310 citations

Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation

1990 • 303 citations

Homosynaptic long-term depression in the visual cortex

1994 • 285 citations

Long-term depression of parallel fibre synapses following stimulation of climbing fibres

1985 • 280 citations

Quisqualate receptors are specifically involved in cerebellar synaptic plasticity

1987 • 273 citations

Reversal of long-term potentiation by inhibitors of haem oxygenase

1993 • 265 citations

Pairing of pre‐ and postsynaptic activities in cerebellar Purkinje cells induces long‐term changes in synaptic efficacy in vitro.

1991 • 264 citations

Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation

1992 • 258 citations

Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression.

1990 • 254 citations

Protein kinase C inhibitors eliminate hippocampal long-term potentiation

1987 • 252 citations

Ca2+ Entry via postsynaptic voltage-sensitive Ca2+ channels can transiently potentiate excitatory synaptic transmission in the hippocampus

1992 • 237 citations

Quantal release of neurotransmitter and long-term potentiation

1993 • 237 citations

Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study

1988 • 234 citations

Asynchronous pre- and postsynaptic activity induces associative long-term depression in area CA1 of the rat hippocampus in vitro.

1994 • 226 citations

Use‐dependent changes in synaptic efficacy in rat prefrontal neurons in vitro.

1990 • 221 citations

Short- and long-term synaptic depression in rat neostriatum

1993 • 205 citations

Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression

1983 • 196 citations

Recovery of spatial learning deficits after decay of electrically induced synaptic enhancement in the hippocampus

1989 • 189 citations

Protein kinases, nitric oxide and long-term depression of synapses in the cerebellum

1990 • 182 citations

Priming of associative long-term depression in the dentate gyrus by θ frequency synaptic activity

1992 • 177 citations

Long‐term Depression Requires Nitric Oxide and Guanosine 3′:5’Cyclic Monophosphate Production in Rat Cerebellar Purkinje Cells

1993 • 170 citations

Depression and potentiation of the synaptic transmission between a granule cell and a Purkinje cell in rat cerebellar culture

1990 • 170 citations

Cellular mechanisms of long-term depression in the cerebellum

1993 • 165 citations

Immunocytochemistry of cGMP in the Cerebellum of the Immature, Adult, and Aged Rat: the Involvement of Nitric Oxide. A Micropharmacological Study

1990 • 159 citations

Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in visual cortex.

1993 • 152 citations

Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a Hebbian rule

1990 • 145 citations

Flip side of synaptic plasticity: Long‐term depression mechanisms in the hippocampus

1994 • 145 citations

Induction of cerebellar long-term depression in culture requires postsynaptic action of Sodium Ions

1993 • 140 citations

Intracellular injection of Ca2+ chelators blocks induction of long-term depression in rat visual cortex.

1992 • 139 citations

Isolated NMDA receptor-mediated synaptic responses express both LTP and LTD

1992 • 133 citations

Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus

1993 • 130 citations

Role of metabotropic glutamate (ACPD) receptors at the parallel fiber-Purkinje cell synapse

1992 • 129 citations

Hebbian Depression of Isolated Neuromuscular Synapses in Vitro

1992 • 128 citations

Long‐term Depression of Glutamate Currents in Cultured Cerebellar Purkinje Neurons Does Not Require Nitric Oxide Signalling

1992 • 125 citations

Stimulation parameters influencing climbing fibre induced long-term depression of parallel fibre synapses

1989 • 124 citations

Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity

1993 • 122 citations

Long-term heterosynaptic inhibition in Aplysia

1988 • 120 citations

Long-term modification of inhibitory synaptic transmission in developing visual cortex

1993 • 119 citations

The involvement of L-type calcium channels in heterosynaptic long-term depression in the hippocampus

1991 • 118 citations

Blockade of NMDA receptors unmasks a long-term depression in synaptic efficacy in rat prefrontal neurons in vitro

1991 • 117 citations

N-methyl-d-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: Input-specific induction and preclusion in a non-tetanized pathway

1992 • 116 citations

The Mechanism of Expression of Long-Term Enhancement of Hippocampal Synapses: Current Issues and Theoretical Implications

1993 • 116 citations

Coactivation of metabotropic glutamate receptors and of voltage-gated calcium channels induces long-term depression in cerebellar Purkinje cells in vitro

1992 • 114 citations

Enhancement of long-term potentiation by cis-unsaturated fatty acid: relation to protein kinase C and phospholipase A2

1987 • 108 citations

Depression of excitatory synaptic input in rat striatal neurons

1993 • 106 citations

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex

1991 • 106 citations

Postsynaptic calcium is necessary for the induction of LTP and LTD of monosynaptic EPSPs in prefrontal neurons: An in vitro study in the rat

1992 • 102 citations

Nitric oxide and hippocampal synaptic plasticity

1993 • 102 citations

Differential pre‐ and postsynaptic mechanisms for synapic potentiation and depression between a granule cell and a purkinje cell in rat cerebellar culture

1991 • 102 citations

Effects of postsynaptic depolarization in the induction of synaptic depression between a granule cell and a Purkinje cell in rat cerebellar culture

1990 • 101 citations

Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in hippocampus

1993 • 97 citations

2-Amino-3-phosphonopropionic acid, an inhibitor of glutamate-stimulated phosphoinositide turnover, blocks induction of homosynaptic long-term depression, but not potentiation, in rat hippocampus

1991 • 96 citations

Commissural synapses, but not mossy fiber synapses, in hippocampal field CA3 exhibit associative long-term potentiation and depression

1989 • 92 citations

NMDA‐dependent heterosynaptic long‐term depression in the dentate gyrus of anaesthetized rats

1992 • 89 citations

The postsynaptic induction of nonassociative long-term depression of excitatory synaptic transmission in rat hippocampal slices

1993 • 86 citations

Cross-depression: an electrophysiological manifestation of binocular competition in the developing visual cortex

1979 • 85 citations

Spatial overlap between populations of synapses determines the extent of their associative interaction during the induction of long-term potentiation and depression

1990 • 78 citations

Mode of induction of long-term depression at parallel fibre—Purkinje cell synapses in rabbit cerebellar cortex

1988 • 76 citations

Long-term potentiation and depression in the ventral horn of rat spinal cord in vitro

1993 • 71 citations

Long-term depression in cerebral cortex: a possible substrate of “forgetting” that should not be forgotten

1993 • 71 citations

Induction of long-term depression and potentiation by low- and high-frequency stimulation in the dentate area of the anesthetized rat: magnitude, time course and EEG

1987 • 70 citations

Heterosynaptic long-term depression is facilitated by blockade of inhibition in area CA1 of the hippocampus

1991 • 69 citations

Heterogeneity of Metabotropic Glutamate Receptors in the Striatum: Electrophysiological Evidence

1993 • 65 citations

Long-term depression at synapses in slices of rat hippocampus can be induced by bursts of postsynaptic activity

1990 • 63 citations

Long-term depression but not potentiation is induced in Ca2+-chelated visual cortex neurons

1990 • 60 citations

Induction of LTP in rat primary visual cortex: tetanus parameters

1989 • 59 citations

NMDA receptor antagonists block the induction of long-term depression in the hippocampal dentate gyrus of the anesthetized rat

1991 • 57 citations

Heterosynaptic correlates of long-term potentiation induction in hippocampal CA3 neurons

1990 • 52 citations

Long‐term potentiation in hippocampal CA3 neurons: Tetanized input regulates heterosynaptic efficacy

1989 • 52 citations

Glutamate iontophoresis induces long-term potentiation in the absence of evoked presynaptic activity

1993 • 45 citations

Impulse activity of a crayfish motoneuron regulated its neuromuscular synaptic properties

1989 • 45 citations

Nitric oxide: a multi-functional messenger substance in cerebellar synaptic plasticity

1993 • 44 citations

Evidence that associative interactions between synapses during the induction of long-term potentiation occur within local dendritic domains.

1988 • 43 citations

Lithium Treatment Blocks Long-Term Synaptic Depression in the Striatum

1993 • 42 citations

Calcium ion effects on guanylate cyclase of brain

1976 • 41 citations

Transient heterosynaptic depression in the hippocampal slice

1978 • 40 citations

The biochemical pharmacology of metabotropic glutamate receptors

1993 • 38 citations

Comparison of associative and non‐associative conditioning procedures in the induction of LTD in CA1 of the hippocampus

1993 • 33 citations

Failure to Induce Long-term Depression by an Anti-Correlation Procedure in Area CA1 of the Rat Hippocampal Slice

1993 • 32 citations

NMDA Receptor‐dependent Transient Homo‐ and Heterosynaptic Depression in Picrotoxin‐treated Hippocampal Slices

1992 • 31 citations

Verapamil counteracts depression but not long-lasting potentiation of the hippocampal population spike

1984 • 28 citations

Input-specific induction of long-term depression in Ca2+-chelated visual cortex neurons

1991 • 27 citations

Homo‐ and heterosynaptic changes in efficacy are expressed in prefrontal neurons: An in vitro study in the rat

1992 • 27 citations

Bicuculline permits the induction of long-term depression by heterosynaptic, translaminar conditioning in the hippocampal dentate gyrus

1993 • 25 citations

Activity-dependent potentiation and depression of visual cortical responses to optic nerve stimulation in kittens

1992 • 24 citations

Pairing of pre- and postsynaptic activities in hippocampal CA1 neurons induces long-term modifications of NMDA receptor-mediated synaptic potential

1993 • 22 citations

Long-term potentiation and depression in hippocampal slices

1986 • 21 citations

Failure to reverse long-term potentiation by coupling sustained presynaptic activity and N-methyl-D-aspartate receptor blockade.

1990 • 20 citations

Associative synaptic potentiation and depression: Quantification of dissociable modifications in the hippocampal dentate gyrus favors a particular class of synaptic modification equations

1990 • 17 citations

Functional plasticity in two afferent systems of the granule cells in the rat dentate area: Frequency-related changes, long-term potentiation and heterosynaptic depression

1985 • 17 citations

Processes in Development: Developmental Patterning of the Vertebrate Limb . J. Richard Hinchliffe, Juan M. Hurle, and Dennis Summerbell, Eds. Plenum, New York, 1991. xii, 452 pp., illus. $115. NATO Advanced Science Institute Series A, vol. 205. From a workshop, Santander, Spain, Sept. 1990.

1992 • 9 citations

Tetanization during GABAA receptor activation induces long-term depression in visual cortex slices

1993 • 9 citations

Longevity of synaptic depression in the hippocampal dentate gyrus

1992 • 8 citations