Granzyme K Directly Processes Bid to Release Cytochrome c and Endonuclease G Leading to Mitochondria-dependent Cell Death

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Cell Death

2004 • 4,599 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Mitochondria, Oxidants, and Aging

2005 • 4,115 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

The Pathophysiology of Mitochondrial Cell Death

2004 • 3,258 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Cytochrome C-Mediated Apoptosis

2004 • 1,297 citations

The antioxidant function of the p53 tumor suppressor

2005 • 1,072 citations

Mitochondrial disease in mouse results in increased oxidative stress

1999 • 634 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor

2003 • 530 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

1999 • 485 citations

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

2003 • 468 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

A mitochondrial perspective on cell death

2001 • 430 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis

2005 • 371 citations

Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

2000 • 342 citations

Do inducers of apoptosis trigger caspase-independent cell death?

2005 • 310 citations

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

2000 • 306 citations

The Protein Import Motor of Mitochondria

1999 • 242 citations

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

2003 • 241 citations

A Role for Proapoptotic BID in the DNA-Damage Response

2005 • 232 citations

Nuclear war: the granzyme A-bomb

2003 • 198 citations

Mitochondria-dependent and -independent Regulation of Granzyme B–induced Apoptosis

1999 • 190 citations

Differential expression of human granzymes A, B, and K in natural killer cells and during CD8⁺ T cell differentiation in peripheral blood

2005 • 168 citations

Granzyme B Induces BID-mediated Cytochrome c Release and Mitochondrial Permeability Transition

2001 • 155 citations

The orphan granzymes of humans and mice

2003 • 152 citations

HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A

2002 • 138 citations

Characterization of three serine esterases isolated from human IL-2 activated killer cells.

1988 • 114 citations

Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells

2006 • 101 citations

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potentin vivo anti-tumor capacity

2001 • 87 citations

Granzyme M Directly Cleaves Inhibitor of Caspase-Activated DNase (CAD) to Unleash CAD Leading to DNA Fragmentation

2006 • 69 citations

Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes

1997 • 58 citations

Detection of soluble human granzyme K in vitro and in vivo

2005 • 54 citations

Molecular mechanisms of lymphocyte-mediated cytotoxicity.

2005 • 50 citations

Generation of Antigenic Peptides by Lymphocyte Granule Serine Proteases (Granzymes)

1996 • 8 citations