Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Lymphocyte-Mediated Cytotoxicity

2002 • 1,079 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Human c- myc Transcription Factor PuF Identified as nm23-H2 Nucleoside Diphosphate Kinase, a Candidate Suppressor of Tumor Metastasis

1993 • 504 citations

Regulation of Histone Acetylation and Transcription by INHAT, a Human Cellular Complex Containing the Set Oncoprotein

2001 • 469 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

2000 • 375 citations

The human Nm23/nucleoside diphosphate kinases.

2000 • 334 citations

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

2003 • 241 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

Granzyme A Loading Induces Rapid Cytolysis and a Novel Form of DNA Damage Independently of Caspase Activation

1999 • 238 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

DFF45/ICAD Can Be Directly Processed by Granzyme B during the Induction of Apoptosis

2000 • 213 citations

Granzyme A Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks

2001 • 174 citations

Molecular Identification of I₁^PP2A, a Novel Potent Heat-Stable Inhibitor Protein of Protein Phosphatase 2A

1996 • 173 citations

DNA Damage in the Nucleosome Core Is Refractory to Repair by Human Excision Nuclease

2000 • 172 citations

The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing

2002 • 170 citations

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

2001 • 166 citations

Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis

1999 • 163 citations

Functional Interaction between Nucleosome Assembly Proteins and p300/CREB-Binding Protein Family Coactivators

2000 • 151 citations

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.

1995 • 149 citations

HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A

2002 • 138 citations

Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation

2002 • 137 citations

Large-scale Fragmentation of Mammalian DNA in the Course of Apoptosis Proceeds via Excision of Chromosomal DNA Loops and Their Oligomers

1995 • 128 citations

Regulation of Histone Acetylation and Transcription by Nuclear Protein pp32, a Subunit of the INHAT Complex

2002 • 128 citations

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

2001 • 126 citations

Cellular Localization and Expression of Template-Activating Factor I in Different Cell Types

1998 • 114 citations

An environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation

2000 • 109 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

1997 • 108 citations

The Gene for Nucleoside Diphosphate Kinase Functions as a Mutator Gene inEscherichia coli

1995 • 105 citations

NM23-H1 and NM23-H2 Repress Transcriptional Activities of Nuclease-hypersensitive Elements in the Platelet-derived Growth Factor-A Promoter

2002 • 104 citations

Induction of Rapid Histone Degradation by the Cytotoxic T Lymphocyte Protease Granzyme A

2001 • 101 citations

Catalysis of DNA cleavage and nucleoside triphosphate synthesis by NM23-H2/NDP kinase share an active site that implies a DNA repair function

2000 • 93 citations

BRCA1: exploring the links to transcription

2000 • 85 citations

Mutational analysis of NM23-H2/NDP kinase identifies the structural domains critical to recognition of a c-myc regulatory element.

1996 • 75 citations

Cleavage of DNA by Human NM23-H2/Nucleoside Diphosphate Kinase Involves Formation of a Covalent Protein-DNA Complex

1999 • 74 citations

Tumor suppression and potentiation by manipulation of pp32 expression

2001 • 73 citations

Structure-Based Mutational and Functional Analysis Identify Human NM23-H2 as a Multifunctional Enzyme

2002 • 51 citations

BCL-2 Blocks Perforin-induced Nuclear Translocation of Granzymes Concomitant with Protection against the Nuclear Events of Apoptosis

1999 • 44 citations

Identification of the Nuclear Factor HMG2 as an Activator for DFF Nuclease Activity

1998 • 38 citations

Cloning and Functional Analysis of the ndk1 Gene Encoding Nucleoside-diphosphate Kinase in Schizosaccharomyces pombe

1995 • 37 citations

Multi-Step Chromatin Degradation in Apoptosis

1994 • 36 citations

Preferential sites of early DNA cleavage in apoptosis and the pathway of nuclear damage

1999 • 20 citations

Untitled

2000 • 10 citations