PDGF and FGF-2 Signaling in Oligodendrocyte Progenitor Cells: Regulation of Proliferation and Differentiation by Multiple Intracellular Signaling Pathways

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

The oligodendrocyte and its many cellular processes

1993 • 837 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

1997 • 704 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.

1981 • 585 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Signal transduction by fibroblast growth factor receptors

1999 • 419 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Identification of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction

1996 • 385 citations

Control of oligodendrocyte number in the developing rat optic nerve

1994 • 385 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

1994 • 326 citations

U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

1992 • 302 citations

PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage

1989 • 224 citations

Neurotransmitter- and Growth Factor-Induced cAMP Response Element Binding Protein Phosphorylation in Glial Cell Progenitors: Role of Calcium Ions, Protein Kinase C, and Mitogen-Activated Protein Kinase/Ribosomal S6 Kinase Pathway

1997 • 189 citations

Glial Cell Mitogens bFGF and PDGF Differentially Regulate Development of O4+GalC- Oligodendrocyte Progenitors

1993 • 170 citations

Regulation of FGF Receptors in the Oligodendrocyte Lineage

1996 • 160 citations

PDGF and intracellular signaling in the timing of oligodendrocyte differentiation.

1989 • 146 citations

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

1994 • 134 citations

Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival

1996 • 127 citations

cAMP-dependent protein kinase A is required for Schwann cell growth: Interactions between the cAMP and neuregulin/tyrosine kinase pathways

1997 • 112 citations

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

1991 • 109 citations

Platelet‐derived growth factor receptor is expressed by cells in the early oligodendrocyte lineage

1994 • 107 citations

Mechanism of action of platelet-derived growth factor

1996 • 99 citations

Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells

1997 • 96 citations

Inhibitory Cross-talk by cAMP Kinase on the Calmodulin-dependent Protein Kinase Cascade

1997 • 90 citations

Activation of Mitogen‐Activated Protein Kinases in Oligodendrocytes

1996 • 79 citations

Inhibition of Protein and Lipid Sulfation in Oligodendrocytes Blocks Biological Responses to FGF-2 and Retards Cytoarchitectural Maturation, but Not Developmental Lineage Progression

1994 • 77 citations

Regulation of oligodendrocyte differentiation: Protein kinase C activation prevents differentiation of O2A progenitor cells toward oligodendrocytes

1998 • 57 citations

Demonstration of Functionally Different Interactions between Phospholipase C-γ and the Two Types of Platelet-derived Growth Factor Receptors

1995 • 55 citations

Oligodendrocyte differentiation and progenitor cell proliferation are independently regulated by cyclic AMP

1993 • 49 citations

Age‐dependent decrease of process formation by cultured oligodendrocytes is augmented by protein kinase C stimulation

1991 • 43 citations

Transient reversion of O4⁺ Galc⁻ oligodendrocyte progenitor development in response to the phorbol ester TPA

1993 • 41 citations

Protein kinases mediate basic fibroblast growth factor's stimulation of proliferation and c-fos induction in oligodendrocyte progenitors

1994 • 38 citations

Developmental expression of protein kinase C isozymes in oligodendrocytes and their differentail modulation by 4β‐phorbol‐12, 13‐dibutyrate

1994 • 31 citations

Protein kinase C prevents oligodendrocyte differentiation: modulation of actin cytoskeleton and cognate polarized membrane traffic

1999 • 31 citations

Phosphorylation of the MARCKS Protein (P87), a Major Protein Kinase C Substrate, Is Not an Obligatory Step in the Mitogenic Signaling Pathway of Basic Fibroblast Growth Factor in Rat Oligodendrocytes

1992 • 26 citations

Phosphorylation of MARCKS (80‐KDA) protein, a major substrate for protein kinase C in oligodendroglial progenitors

1991 • 22 citations