Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester

2007 • 583 citations

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

1999 • 426 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Prediction of Autoantibody Positivity and Progression to Type 1 Diabetes: Diabetes Autoimmunity Study in the Young (DAISY)

2004 • 336 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

2004 • 240 citations

Tolerance to Islet Autoantigens in Type 1 Diabetes

2001 • 236 citations

Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

2005 • 210 citations

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

2002 • 198 citations

Characterization of Peripheral Regulatory CD4+ T Cells That Prevent Diabetes Onset in Nonobese Diabetic Mice

2000 • 192 citations

Human CD25⁺ regulatory T cells: two subsets defined by the integrins α₄β₇ or α₄β₁ confer distinct suppressive properties upon CD4⁺ T helper cells

2004 • 172 citations

The Role of Helper T Cell Subsets in Autoimmune Diseases

1998 • 163 citations

The Role of CD40–CD154 Interactions in Autoimmunity and the Benefit of Disrupting this Pathway

2004 • 161 citations

Activation‐induced cell death: The controversial role of Fas and Fas ligand in immune privilege and tumour counterattack

2002 • 154 citations

Monoclonal antibodies to murine CD40 define two distinct functional epitopes

1994 • 152 citations

T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity.

1994 • 149 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes

2002 • 117 citations

Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control

2005 • 110 citations

Increased CD40 ligand and platelet–monocyte aggregates in patients with type 1 diabetes mellitus

2004 • 105 citations

Diabetes in non‐obese diabetic mice is not associated with quantitative changes in CD4⁺ CD25⁺ Foxp3⁺ regulatory T cells

2007 • 95 citations

Inhibition of Autoimmune Diabetes by Fas Ligand: The Paradox Is Solved

2000 • 89 citations

Dichotomy between naïve and memory CD4⁺T cell responses to Fas engagement

1999 • 87 citations

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects

2005 • 85 citations

Enhanced thymic selection of FoxP3 ⁺ regulatory T cells in the NOD mouse model of autoimmune diabetes

2007 • 78 citations

Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen

2004 • 77 citations

Regulation of synovial B cell survival in rheumatoid arthritis by vascular cell adhesion molecule 1 (CD106) expressed on fibroblast-like synoviocytes

2000 • 74 citations

Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failure

2003 • 73 citations

Transgenic Insulin (B:9-23) T-Cell Receptor Mice Develop Autoimmune Diabetes Dependent Upon RAG Genotype, H-2g7 Homozygosity, and Insulin 2 Gene Knockout

2006 • 68 citations

Cutting Edge: CD40-Induced Expression of Recombination Activating Gene (RAG) 1 and RAG2: A Mechanism for the Generation of Autoaggressive T Cells in the Periphery

2003 • 64 citations

Helper T cells in antibody-mediated, organ-specific autoimmunity

2000 • 63 citations

Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.

1996 • 63 citations

Peripheral CD4^loCD40⁺ auto‐aggressive T cell expansion during insulin‐dependent diabetes mellitus

2004 • 59 citations

A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes

2007 • 58 citations

Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4+CD25+ T-Cell–Mediated Regulation and Type 1 Diabetes Development in NOD Mice

2006 • 57 citations

Intranasal Vaccination with Proinsulin DNA Induces Regulatory CD4+ T Cells That Prevent Experimental Autoimmune Diabetes

2006 • 57 citations

T Cells Recognize Multiple GAD65 and Proinsulin Epitopes in Human Type 1 Diabetes, Suggesting Determinant Spreading

2004 • 55 citations

Role of Fas–FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease

1999 • 53 citations

Autoimmune diabetes results from genetic defects manifest by antigen presenting cells

1993 • 48 citations

Increased expression of CD40 on thymocytes and peripheral T cells in autoimmunity: a mechanism for acquiring changes in the peripheral T cell receptor repertoire.

1999 • 37 citations

Insulin-Specific Tolerance in Diabetes

2002 • 33 citations

Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad

2006 • 31 citations

The role of regulatory t lymphocytes in asthma pathogenesis

2005 • 30 citations

CD4+CD25+ regulatory T cells control the progression from periinsulitis to destructive insulitis in murine autoimmune diabetes

2005 • 24 citations

Hypothesis: A recurrent, moderate activation fosters systemic autoimmunity — the apoptotic roles of TCR, IL-2 and fas ligand

1999 • 9 citations