Regulation of synovial B cell survival in rheumatoid arthritis by vascular cell adhesion molecule 1 (CD106) expressed on fibroblast-like synoviocytes

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Humoral Immunity Due to Long-Lived Plasma Cells

1998 • 1,223 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Inhibition of T cell apoptosis in the rheumatoid synovium.

1997 • 474 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.

1996 • 433 citations

Decrease in cellularity and expression of adhesion molecules by anti–tumor necrosis factor α monoclonal antibody treatment in patients with rheumatoid arthritis

1996 • 377 citations

The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.

1981 • 359 citations

Phenotypic difference of normal plasma cells from mature myeloma cells

1993 • 323 citations

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

1994 • 314 citations

Long-lived plasma cells: a mechanism for maintaining persistent antibody production

1998 • 312 citations

Distinct short‐lived and long‐lived antibody‐producing cell populations

1986 • 276 citations

Plasma Cell Development in Synovial Germinal Centers in Patients with Rheumatoid and Reactive Arthritis

1999 • 224 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes.

1992 • 202 citations

Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis

1995 • 173 citations

The Identification of Germinal Centres and Follicular Dendritic Cell Networks in Rheumatoid Synovial Tissue

1995 • 167 citations

Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study.

1992 • 150 citations

Antiglobulin factors in sera from patients with rheumatoid arthritis and normal subjects. Quantitative estimation in different immunoglobulin classes.

1967 • 143 citations

Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts.

1996 • 142 citations

Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells

1992 • 137 citations

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

1994 • 133 citations

The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium.

1995 • 124 citations

Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients Have Intrinsic Properties of Follicular Dendritic Cells

1999 • 123 citations

Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells.

1998 • 112 citations

Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95‐induced apoptosis

1997 • 108 citations

IgG rheumatoid factor

1979 • 94 citations

IgG and IgM rheumatoid factor synthesis in rheumatoid synovial membrane cell cultures

1985 • 85 citations

Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patients

1998 • 58 citations

Normal and neoplastic human plasma cells express bcl-2 antigen.

1991 • 47 citations

Sustained Elevated Levels of VCAM-1 in Cultured Fibroblast-like Synoviocytes Can Be Achieved by TNF-α in Combination with Either IL-4 or IL-13 through Increased mRNA Stability

1999 • 45 citations

Establishment and characterization of nurse cell-like stromal cell lines from synovial tissues of patients with rheumatoid arthritis

1999 • 43 citations

Proinflammatory Cytokines Enhance Human Synoviocyte Expression of Functional Intercellular Adhesion Molecule-1 (ICAM-1)

1993 • 38 citations

Immunology of systemic rheumatoid disease

1995 • 24 citations

Enhancement of terminal B lymphocyte differentiationin vitro by fibroblast-like stromal cells from human spleen

1998 • 15 citations