T Cells Recognize Multiple GAD65 and Proinsulin Epitopes in Human Type 1 Diabetes, Suggesting Determinant Spreading

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Strategies for epitope analysis using peptide synthesis

1987 • 887 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes

2000 • 456 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes

1990 • 356 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes

1999 • 223 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

2002 • 198 citations

HLA‐DR, DO AND DP TYPING USING PCR AMPLIFICATION AND IMMOBILIZED PROBES

1991 • 197 citations

Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice

2002 • 195 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

2002 • 175 citations

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.

1995 • 173 citations

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

1998 • 160 citations

Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

1995 • 158 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1996 • 139 citations

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

1991 • 138 citations

Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays

1999 • 130 citations

Direct Visualization of Cytokine-Producing Recall Antigen-Specific CD4 Memory T Cells in Healthy Individuals and HIV Patients

2000 • 129 citations

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

1994 • 128 citations

Evolution of the Enzyme-Linked Immunosorbent Spot Assay for Post-Transplant Alloreactivity as a Potentially Useful Immune Monitoring Tool

2002 • 121 citations

Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes.

2000 • 100 citations

Early Development and Spreading of Autoantibodies to Epitopes of IA-2 and Their Association with Progression to Type 1 Diabetes

1998 • 100 citations

Intermolecular Antigen Spreading Occurs During the Preclinical Period of Human Type 1 Diabetes

2001 • 93 citations

Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65)

2001 • 93 citations

Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus

1994 • 91 citations

T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects

1997 • 81 citations

Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes

2001 • 79 citations

T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy Subjects

1999 • 76 citations

The naive repertoire of human T helper cells specific for gp120, the envelope glycoprotein of HIV.

1991 • 66 citations

Shifting T‐cell activation thresholds in autoimmunity and determinant spreading

1998 • 53 citations

It's Insulin

2000 • 49 citations

The Karlsburg Type 1 Diabetes Risk Study of a Normal Schoolchild Population: Association of β-Cell Autoantibodies and Human Leukocyte Antigen-DQB1 Alleles in Antibody-Positive Individuals

2002 • 41 citations

Does GAD Have a Unique Role in Triggering IDDM?

2000 • 38 citations

Pathogenicity of T cells responsive to diverse cryptic epitopes of myelin basic protein in the Lewis rat.

1995 • 38 citations

Differential Presentation of Glutamic Acid Decarboxylase 65 (GAD65) T Cell Epitopes Among HLA-DRB1*0401-Positive Individuals

1999 • 32 citations

Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction

2003 • 24 citations

Modern concepts for the prediction of type 1 diabetes

2001 • 23 citations