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Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)

Data up to Jan 2025

Published2009
Citations3,831
References260

Total Citations Per Year

Abstract

References (260)

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2002 • 1,760 citations

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Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

2001 • 1,521 citations

Cellular and molecular pathobiology of pulmonary arterial hypertension

2004 • 1,521 citations

Long-term intravenous epoprostenol infusion in primary pulmonary hypertension

2002 • 1,383 citations

Continuous Subcutaneous Infusion of Treprostinil, a Prostacyclin Analogue, in Patients with Pulmonary Arterial Hypertension

2002 • 1,382 citations

Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease

2004 • 1,259 citations

Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure

2001 • 1,217 citations

Survival in Primary Pulmonary Hypertension

2002 • 1,192 citations

Chronic thromboembolic pulmonary hypertension.

2006 • 1,170 citations

Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension

2005 • 1,135 citations

Clinical Correlates and Prognostic Significance of Six-minute Walk Test in Patients with Primary Pulmonary Hypertension

2000 • 1,129 citations

Diagnosis and Assessment of Pulmonary Arterial Hypertension

2009 • 1,120 citations

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

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Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease

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Tricuspid Annular Displacement Predicts Survival in Pulmonary Hypertension

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Tadalafil Therapy for Pulmonary Arterial Hypertension

2009 • 1,034 citations

Ambrisentan for the Treatment of Pulmonary Arterial Hypertension

2008 • 1,033 citations

Accuracy of Doppler Echocardiography in the Hemodynamic Assessment of Pulmonary Hypertension

2009 • 1,008 citations

Diagnosis and differential assessment of pulmonary arterial hypertension

2004 • 1,000 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

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Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review

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1996 • 966 citations

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2005 • 933 citations

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2008 • 910 citations

Echocardiographic Assessment of Pulmonary Hypertension in Patients with Advanced Lung Disease

2003 • 890 citations

Chronic thromboembolic pulmonary hypertension

2018 • 885 citations

Plasma Brain Natriuretic Peptide as a Prognostic Indicator in Patients With Primary Pulmonary Hypertension

2000 • 881 citations

Prevalence and Outcomes of Pulmonary Arterial Hypertension in Advanced Idiopathic Pulmonary Fibrosis

2006 • 828 citations

Molecular pharmacology

1994 • 813 citations

Bosentan Therapy in Patients With Eisenmenger Syndrome

2006 • 811 citations

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

2009 • 788 citations

Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension

2002 • 788 citations

Chronic Thromboembolic Pulmonary Hypertension

2001 • 780 citations

Diastolic Heart Failure

2004 • 772 citations

An epidemiological study of pulmonary arterial hypertension

2007 • 768 citations

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

2002 • 763 citations

Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach

2003 • 750 citations

Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study

2005 • 738 citations

Sitaxsentan Therapy for Pulmonary Arterial Hypertension

2003 • 723 citations

Clinical and Molecular Genetic Features of Pulmonary Hypertension in Patients with Hereditary Hemorrhagic Telangiectasia

2001 • 714 citations

Exercise and Respiratory Training Improve Exercise Capacity and Quality of Life in Patients With Severe Chronic Pulmonary Hypertension

2006 • 702 citations

Pathologic assessment of vasculopathies in pulmonary hypertension

2004 • 697 citations

Treatment of Primary Pulmonary Hypertension with Continuous Intravenous Prostacyclin (Epoprostenol)

1990 • 688 citations

Reduction in Pulmonary Vascular Resistance with Long-Term Epoprostenol (Prostacyclin) Therapy in Primary Pulmonary Hypertension

1998 • 674 citations

Pulmonary Arterial Hypertension

2006 • 668 citations

Recommendations on the use of exercise testing in clinical practice

2006 • 667 citations

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

2009 • 663 citations

Severe Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease

2005 • 659 citations

A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST)

1997 • 658 citations

A meta-analysis of randomized controlled trials in pulmonary arterial hypertension

2008 • 657 citations

Clinical Correlates and Reference Intervals for Pulmonary Artery Systolic Pressure Among Echocardiographically Normal Subjects

2001 • 654 citations

Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial

2002 • 639 citations

Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2

2004 • 632 citations

Beraprost therapy for pulmonary arterial hypertension

2003 • 627 citations

Randomized Study of Adding Inhaled Iloprost to Existing Bosentan in Pulmonary Arterial Hypertension

2006 • 622 citations

Survival with first-line bosentan in patients with primary pulmonary hypertension

2005 • 611 citations

Addition of Sildenafil to Long-Term Intravenous Epoprostenol Therapy in Patients with Pulmonary Arterial Hypertension

2008 • 609 citations

Genetics and Genomics of Pulmonary Arterial Hypertension

2013 • 606 citations

Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension

2001 • 598 citations

Pulmonary Hemodynamics and Perioperative Cardiopulmonary-Related Mortality in Patients With Portopulmonary Hypertension Undergoing Liver Transplantation

2000 • 590 citations

Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?

2008 • 573 citations

Registry of the International Society for Heart and Lung Transplantation: Twenty-third Official Adult Heart Transplantation Report—2006

2006 • 569 citations

Assessment of Survival in Patients With Primary Pulmonary Hypertension

2002 • 562 citations

Complications of Right Heart Catheterization Procedures in Patients With Pulmonary Hypertension in Experienced Centers

2006 • 562 citations

Ventilation-Perfusion Scintigraphy Is More Sensitive than Multidetector CTPA in Detecting Chronic Thromboembolic Pulmonary Disease as a Treatable Cause of Pulmonary Hypertension

2007 • 560 citations

Value of a Doppler-Derived Index Combining Systolic and Diastolic Time Intervals in Predicting Outcome in Primary Pulmonary Hypertension

1998 • 560 citations

Primary pulmonary hypertension

1998 • 539 citations

Bosentan for Treatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension

2008 • 533 citations

Predictive Factors of Hospitalization for Acute Exacerbation in a Series of 64 Patients with Chronic Obstructive Pulmonary Disease

1999 • 526 citations

Prognosis of Pulmonary Arterial Hypertension*

2004 • 523 citations

Eisenmenger syndrome. Factors relating to deterioration and death

1998 • 522 citations

Long-Term Prostacyclin for Pulmonary Hypertension With Associated Congenital Heart Defects

1999 • 510 citations

Updated Evidence-Based Treatment Algorithm in Pulmonary Arterial Hypertension

2009 • 505 citations

Sildenafil Improves Exercise Capacity and Quality of Life in Patients With Systolic Heart Failure and Secondary Pulmonary Hypertension

2007 • 503 citations

The endothelin system in pulmonary arterial hypertension

2004 • 498 citations

Prognostic Factors in COPD Patients Receiving Long-term Oxygen Therapy

1995 • 497 citations

Ambrisentan Therapy for Pulmonary Arterial Hypertension

2005 • 491 citations

Portopulmonary hypertension and hepatopulmonary syndrome

2004 • 488 citations

Treatment of Pulmonary Arterial Hypertension With the Selective Endothelin-A Receptor Antagonist Sitaxsentan

2006 • 481 citations

Pulmonary Hemodynamics in Advanced COPD Candidates for Lung Volume Reduction Surgery or Lung Transplantation

2005 • 479 citations

Goal-oriented treatment and combination therapy for pulmonary arterial hypertension

2005 • 472 citations

Pulmonary veno-occlusive disease

2016 • 453 citations

Long-Term Oxygen Therapy Can Reverse the Progression of Pulmonary Hypertension in Patients with Chronic Obstructive Pulmonary Disease

1985 • 448 citations

Prevalence of HIV-related Pulmonary Arterial Hypertension in the Current Antiretroviral Therapy Era

2007 • 445 citations

Selection and Treatment of Candidates for Heart Transplantation

1995 • 438 citations

Comparison of the hemodynamics and survival of adults with severe primary pulmonary hypertension or Eisenmenger syndrome.

1996 • 435 citations

Hemodynamics and Survival in Patients With Pulmonary Arterial Hypertension Related to Systemic Sclerosis*

2003 • 431 citations

Vasodilator Therapy for Primary Pulmonary Hypertension in Children

1999 • 425 citations

Diagnosis, Assessment, and Treatment of Non-Pulmonary Arterial Hypertension Pulmonary Hypertension

2009 • 415 citations

Influence of preoperative pulmonary artery pressure on mortality after heart transplantation: Testing of potential reversibility of pulmonary hypertension with nitroprusside is useful in defining a high risk group

1992 • 414 citations

Mutations of the TGF-β type II receptorBMPR2 in pulmonary arterial hypertension

2006 • 404 citations

Serum N-Terminal Brain Natriuretic Peptide as a Prognostic Parameter in Patients With Pulmonary Hypertension

2006 • 400 citations

Inhaled Prostacyclin and Iloprost in Severe Pulmonary Hypertension Secondary to Lung Fibrosis

1999 • 399 citations

Chronic thromboembolic pulmonary hypertension

2004 • 396 citations

Improved Outcomes in Medically and Surgically Treated Chronic Thromboembolic Pulmonary Hypertension

2008 • 396 citations

Risk factors for chronic thromboembolic pulmonary hypertension

2008 • 393 citations

Interventricular Mechanical Asynchrony in Pulmonary Arterial Hypertension

2008 • 388 citations

Pulmonary Vascular Disease in Adults With Congenital Heart Disease

2007 • 387 citations

Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension

2003 • 381 citations

Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis

2004 • 376 citations

Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart disease

2006 • 373 citations

The Short-term Effects of Digoxin in Patients With Right Ventricular Dysfunction From Pulmonary Hypertension

1998 • 372 citations

Immunosuppressive therapy in lupus‐ and mixed connective tissue disease–associated pulmonary arterial hypertension: A retrospective analysis of twenty‐three cases

2008 • 366 citations

Portopulmonary hypertension: Results from a 10-year screening algorithm

2006 • 366 citations

Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension

2003 • 360 citations

Pulmonary vascular disorders in portal hypertension

1998 • 360 citations

Graded balloon dilation atrial septostomy in severe primary pulmonary hypertension

1998 • 355 citations

Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells

2005 • 354 citations

Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension

2003 • 352 citations

Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry

2006 • 346 citations

Genetics and Genomics of Pulmonary Arterial Hypertension

2009 • 336 citations

Expert consensus document on management of cardiovascular diseases during pregnancy The Task Force on the Management of Cardiovascular Diseases During Pregnancy of the European Society of Cardiology

2003 • 333 citations

Fibrous remodeling of the pulmonary venous system in pulmonary arterial hypertension associated with connective tissue diseases

2007 • 331 citations

Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil

2006 • 329 citations

Prognostic Factors for Survival in Human Immunodeficiency Virus–associated Pulmonary Arterial Hypertension

2003 • 318 citations

Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms.

1992 • 318 citations

Detectable Serum Cardiac Troponin T as a Marker of Poor Prognosis Among Patients With Chronic Precapillary Pulmonary Hypertension

2003 • 309 citations

HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study.

1997 • 303 citations

Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension

2006 • 299 citations

Results of European post-marketing surveillance of bosentan in pulmonary hypertension

2007 • 297 citations

Deleterious Effects of β-Blockers on Exercise Capacity and Hemodynamics in Patients With Portopulmonary Hypertension

2006 • 297 citations

Sildenafil for Long-Term Treatment of Nonoperable Chronic Thromboembolic Pulmonary Hypertension

2003 • 294 citations

Severe Pulmonary Hypertension during Pregnancy

2005 • 293 citations

Pulmonary Veno-occlusive Disease

2000 • 292 citations

Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension

2006 • 291 citations

Safety and Efficacy of IV Treprostinil for Pulmonary Arterial Hypertension

2006 • 290 citations

Improvement in pulmonary hemodynamics during intravenous epoprostenol (prostacyclin): A study of 15 patients with moderate to severe portopulmonary hypertension

1999 • 288 citations

Clinical Outcomes of Pulmonary Arterial Hypertension in Carriers of BMPR2 Mutation

2008 • 288 citations

Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension

2004 • 285 citations

Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure

2005 • 284 citations

Oxygen desaturation on the six-minute walk test and mortality in untreated primary pulmonary hypertension

2001 • 282 citations

Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension

2004 • 277 citations

Pulmonary veno-occlusive disease

2008 • 274 citations

Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study

2005 • 274 citations

Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease

1996 • 269 citations

Development and Pathology of Pulmonary Hypertension

2009 • 265 citations

Effects of Long-Term Bosentan in Children With Pulmonary Arterial Hypertension

2005 • 263 citations

Incidence and clinical relevance of supraventricular tachyarrhythmias in pulmonary hypertension

2006 • 262 citations

Registry of the International Society for Heart and Lung Transplantation: Twenty-third Official Adult Lung and Heart–Lung Transplantation Report—2006

2006 • 260 citations

Bosentan for the Treatment of Human Immunodeficiency Virus–associated Pulmonary Arterial Hypertension

2004 • 260 citations

Treprostinil, a Prostacyclin Analogue, in Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

2004 • 257 citations

Pulmonary Hypertension: CT of the Chest in Pulmonary Venoocclusive Disease

2004 • 256 citations

Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.

1989 • 250 citations

Beneficial Effect of Oral Sildenafil Therapy on Childhood Pulmonary Arterial Hypertension

2005 • 250 citations

Sildenafil Improves Walk Distance in Idiopathic Pulmonary Fibrosis

2007 • 249 citations

Interventional and Surgical Modalities of Treatment in Pulmonary Hypertension

2009 • 247 citations

Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: Results of the BREATHE-5 open-label extension study

2007 • 244 citations

Non-invasive diagnosis of hepatic cirrhosis by transit-time analysis of an ultrasound contrast agent

1999 • 241 citations

CONTINUOUS INTRAVENOUS INFUSION OF EPOPROSTENOL FOR THE TREATMENT OF PORTOPULMONARY HYPERTENSION1

1997 • 241 citations

Polymorphism of the Serotonin Transporter Gene and Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease

2003 • 233 citations

Anxiety and Depression in Patients With Pulmonary Hypertension

2004 • 225 citations

Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol

2005 • 223 citations

Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

2005 • 220 citations

Pulmonary Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension

2006 • 217 citations

Factors that influence the outcome of primary pulmonary hypertension.

1986 • 217 citations

Prostacyclin Therapy Before Pulmonary Thromboendarterectomy in Patients With Chronic Thromboembolic Pulmonary Hypertension*

2003 • 215 citations

Nocturnal Oxygen Therapy in Patients with the Eisenmenger Syndrome

2001 • 215 citations

Pulmonary Veno-occlusive Disease

2000 • 215 citations

Sildenafil treatment for portopulmonary hypertension

2006 • 212 citations

Estimating pulmonary artery pressures by echocardiography in patients with emphysema

2007 • 212 citations

Sildenafil for pulmonary arterial hypertension associated with connective tissue disease.

2007 • 211 citations

Long term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension

1998 • 211 citations

Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension

2009 • 211 citations

Eisenmenger Syndrome

2009 • 206 citations

Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids

2003 • 206 citations

Short- and Long-Term Effects of Inhaled Iloprost Therapy in Children With Pulmonary Arterial Hypertension

2008 • 203 citations

Bosentan Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension

2005 • 202 citations

PATHOBIOLOGY OF PULMONARY HYPERTENSION

2001 • 200 citations

Efficacy of Long-term Subcutaneous Treprostinil Sodium Therapy in Pulmonary Hypertension

2006 • 200 citations

Bosentan therapy for portopulmonary hypertension

2005 • 200 citations

Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension

2006 • 197 citations

Management of Pulmonary Arterial Hypertension Associated with Congenital Systemic-to-Pulmonary Shunts and Eisenmenger???s Syndrome

2008 • 194 citations

Pulmonary Hypertension Associated with Left-Sided Heart Disease

2007 • 193 citations

Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells

2004 • 191 citations

Ambrisentan Therapy in Patients With Pulmonary Arterial Hypertension Who Discontinued Bosentan or Sitaxsentan Due to Liver Function Test Abnormalities

2008 • 187 citations

Experience with inhaled iloprost and bosentan in portopulmonary hypertension

2007 • 183 citations

High Prevalence of Autoimmune Thyroid Disease in Pulmonary Arterial Hypertension

2002 • 182 citations

Pulmonary Edema Complicating Continuous Intravenous Prostacyclin in Pulmonary Capillary Hemangiomatosis

1998 • 181 citations

Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension

2007 • 181 citations

Pulmonary Arterial Thrombosis in Eisenmenger Syndrome Is Associated With Biventricular Dysfunction and Decreased Pulmonary Flow Velocity

2007 • 178 citations

Pregnancy and contraception in heart disease and pulmonary arterial hypertension

2006 • 171 citations

Outcome after Cardiopulmonary Resuscitation in Patients with Pulmonary Arterial Hypertension

2002 • 167 citations

Antinuclear antibodies in primary pulmonary hypertension

1986 • 163 citations

Atrial Septostomy in Treatment of End-Stage Right Heart Failure in Patients With Pulmonary Hypertension

2007 • 161 citations

Heart–lung or lung transplantation for Eisenmenger syndrome

2002 • 161 citations

Hypoxic Pulmonary Vasoconstriction and Gas Exchange During Exercise in Chronic Obstructive Pulmonary Disease

1990 • 161 citations

The remarkable right ventricle of patients with Eisenmenger syndrome

2005 • 158 citations

Cardiopulmonary Exercise Testing and Six-Minute Walk Correlations in Pulmonary Arterial Hypertension

2005 • 155 citations

Prostanoids for Pulmonary Arterial Hypertension

2003 • 152 citations

Continuous intravenous epoprostenol for chronic thromboembolic pulmonary hypertension

2004 • 152 citations

Bosentan Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension

2005 • 152 citations

N-Terminal Pro-B-Type Natriuretic Peptide as an Indicator of Disease Severity in a Heterogeneous Group of Patients With Chronic Precapillary Pulmonary Hypertension

2006 • 151 citations

Pulmonary Veno-occlusive Disease Caused by an Inherited Mutation in Bone Morphogenetic Protein Receptor II

2003 • 149 citations

Chronic thromboembolic pulmonary hypertension: Evaluation with 64-detector row CT versus digital substraction angiography

2008 • 148 citations

Intravenous Epoprostenol in Inoperable Chronic Thromboembolic Pulmonary Hypertension

2007 • 144 citations

Occult alveolar haemorrhage in pulmonary veno-occlusive disease

2005 • 142 citations

Growth Differentiation Factor-15 in Idiopathic Pulmonary Arterial Hypertension

2008 • 139 citations

Sildenafil treatment in COPD does not affect stroke volume or exercise capacity

2007 • 137 citations

Hyperuricemia in Severe Pulmonary Hypertension

2000 • 137 citations

Phosphodiesterase-5 Inhibitor in Eisenmenger Syndrome

2006 • 137 citations

Pulmonary arterial hypertension in children

2004 • 136 citations

Role of atrial septostomy in the treatment of children with pulmonary arterial hypertension

2005 • 136 citations

Activation of thromboxane and prostacyclin receptors elicits opposing effects on vascular smooth muscle cell growth and mitogen-activated protein kinase signaling cascades.

1995 • 128 citations

Immediate and Long-term Hemodynamic and Clinical Effects of Sildenafil in Patients With Pulmonary Arterial Hypertension Receiving Vasodilator Therapy

2003 • 125 citations

Role of pharmacologic tests in the treatment of primary pulmonary hypertension

1995 • 124 citations

Prevalence and characteristics of moderate to severe pulmonary hypertension in systemic sclerosis with and without interstitial lung disease.

2007 • 124 citations

Prognostic Implications of Serial Assessments of Pulmonary Hypertension in Severe Chronic Heart Failure

2006 • 121 citations

Guidelines for the prevention of central venous catheter-related blood stream infections with prostanoid therapy for pulmonary arterial hypertension

2008 • 120 citations

A potential role for sildenafil in the management of pulmonary hypertension in patients with parenchymal lung disease

2006 • 120 citations

Epoprostenol treatment in children with severe pulmonary hypertension

2006 • 117 citations

Pharmacokinetic Interaction Between Tadalafil and Bosentan in Healthy Male Subjects

2008 • 117 citations

Indications for and Outcomes After Combined Lung and Liver Transplantation: A Single-Center Experience on 13 Consecutive Cases

2008 • 117 citations

Hepatopulmonary syndrome and portopulmonary hypertension

2003 • 114 citations

Plasma coagulation profiles in patients with severe primary pulmonary hypertension

1998 • 112 citations

Pregnancy Outcome in Patients With Pulmonary Arterial Hypertension Receiving Prostacyclin Therapy

2005 • 107 citations

Sitaxsentan for the Treatment of Pulmonary Arterial Hypertension

2008 • 106 citations

Selective endothelinA receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease

2007 • 100 citations

Pulmonary Veno-occlusive Disease*

2000 • 90 citations

Rapid Switch From Intravenous Epoprostenol to Intravenous Treprostinil in Patients With Pulmonary Arterial Hypertension

2007 • 89 citations

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease

2005 • 88 citations

Sildenafil improves hemodynamic parameters in COPD—an investigation of six patients

2005 • 88 citations

Mild vs Severe Pulmonary Hypertension Before Heart Transplantation: Different Effects on Posttransplantation Pulmonary Hypertension and Mortality

2005 • 85 citations

Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland

2008 • 85 citations

Características clínicas dos pacientes com hipertensão pulmonar em dois centros de referência em São Paulo

2006 • 83 citations

Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study

2007 • 79 citations

Fibrinogen, t-PA, and PAI-1 plasma levels in patients with pulmonary hypertension.

1994 • 78 citations

New approaches for persistent pulmonary hypertension of newborn

2004 • 78 citations

Inhaled iloprost is a potent acute pulmonary vasodilator in HIV‐related severe pulmonary hypertension

2004 • 77 citations

Current and Future Management of Chronic Thromboembolic Pulmonary Hypertension: From Diagnosis to Treatment Responses

2006 • 77 citations

Heart-type fatty acid-binding protein for risk assessment of chronic thromboembolic pulmonary hypertension

2008 • 70 citations

Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland

2008 • 67 citations

Importance of Angiotensin-Converting Enzyme in Pulmonary Hypertension

1995 • 66 citations

Long-term treatment of chronic obstructive lung disease by Nifedipine: an 18-month haemodynamic study

1988 • 60 citations

Long-term Follow-up of a Fenestrated Amplatzer Atrial Septal Occluder in Pulmonary Arterial Hypertension

2008 • 49 citations

Mechanisms of improved arterial oxygenation after peripheral chemoreceptor stimulation during hypoxic exercise

1993 • 47 citations

Addition of Sildenafil to Long-Term Intravenous Epoprostenol Therapy in Patients with Pulmonary Arterial Hypertension

2008 • 47 citations

Tratamiento de la hipertensión pulmonar asociada a la infección por VIH con treprostinil

2003 • 46 citations

Effects Of Sildenafil Treatment In Patients With Pulmonary Hypertension Associated With Congenital Cardiac Shunts

2010 • 9 citations

Long-term effect of bosentan in paediatric versus adult patients with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt : does the beneficial effect persist?

2007 • 8 citations

Tratamiento de la hipertensión pulmonar asociada a la infección por VIH con treprostinil

2003 • 6 citations

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