Back to search

Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

Data up to Jan 2025

Published2005
Citations220
References17

Total Citations Per Year

Abstract

References (17)

Bosentan Therapy for Pulmonary Arterial Hypertension

2002 • 2,715 citations

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

2001 • 1,521 citations

Cyclic GMP Phosphodiesterase-5: Target of Sildenafil

1999 • 536 citations

Primary pulmonary hypertension

2003 • 526 citations

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1999 • 397 citations

Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality

2002 • 347 citations

Clinical Pharmacology of Bosentan, a Dual Endothelin Receptor Antagonist

2004 • 257 citations

Chronic Sildenafil Treatment Inhibits Monocrotaline-induced Pulmonary Hypertension in Rats

2003 • 253 citations

Phosphodiesterase Type 5 as a Target for the Treatment of Hypoxia-Induced Pulmonary Hypertension

2003 • 244 citations

Inhibitory effects of amiodarone and its N‐deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions

2000 • 179 citations

Identification of the cytochrome P450 enzymes involved in the N‐demethylation of sildenafil

2001 • 152 citations

In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions.

2000 • 133 citations

Comparative human pharmacokinetics and metabolism of single‐dose oral and intravenous sildenafil

2002 • 119 citations

Clinical and haemodynamic effects of sildenafil in pulmonary hypertension: acute and mid-term effects

2004 • 110 citations

Simultaneous assay of sildenafil and desmethylsildenafil in human plasma using liquid chromatography–tandem mass spectrometry on silica column with aqueous–organic mobile phase

2002 • 83 citations

A study of clinical efficacy of sildenafil in patients with primary pulmonary hypertension.

2002 • 71 citations

The effects of steady‐state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers

2002 • 56 citations

Cited By (0)

Loading...