New approaches for persistent pulmonary hypertension of newborn

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,435 citations

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

2003 • 1,341 citations

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.

1991 • 1,134 citations

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension

1991 • 1,062 citations

Inhaled nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 865 citations

Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure

1997 • 837 citations

Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

1997 • 787 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Low-Dose Nitric Oxide Therapy for Persistent Pulmonary Hypertension of the Newborn

2000 • 703 citations

Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn

1997 • 567 citations

Persistent Pulmonary Hypertension of the Newborn in the Era Before Nitric Oxide: Practice Variation and Outcomes

2000 • 558 citations

Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth

1990 • 447 citations

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

1978 • 446 citations

Inhaled Nitric Oxide and Hypoxic Respiratory Failure in Infants With Congenital Diaphragmatic Hernia

1997 • 429 citations

Inhaled Nitric Oxide in Premature Infants with the Respiratory Distress Syndrome

2003 • 420 citations

Oral sildenafil in the treatment of erectile dysfunction

2002 • 406 citations

Management of Infants With Severe Respiratory Failure and Persistence of the Fetal Circulation, Without Hyperventilation

1985 • 361 citations

Inhaled Nitric Oxide for the Early Treatment of Persistent Pulmonary Hypertension of the Term Newborn: A Randomized, Double-Masked, Placebo-Controlled, Dose-Response, Multicenter Study

1998 • 355 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure

1998 • 334 citations

Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase

2001 • 323 citations

The vascular resistance of the foetal and newly ventilated lung of the lamb

1964 • 270 citations

Changes in the lungs of the new‐born lamb

1953 • 269 citations

Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: Dose response

1994 • 267 citations

Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial

1999 • 261 citations

Oxidative stress and vascular damage in hypertension

2000 • 240 citations

Congenital Diaphragmatic Hernia

2002 • 237 citations

Increased Superoxide Generation Is Associated With Pulmonary Hypertension in Fetal Lambs

2003 • 230 citations

Prolonged Administration of <scp>l</scp> -Arginine Ameliorates Chronic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats

1997 • 223 citations

Neonatal Pulmonary Hypertension

2001 • 216 citations

Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn

1976 • 209 citations

Short-term Oral Administration of <scp>l-</scp>Arginine Improves Hemodynamics and Exercise Capacity in Patients with Precapillary Pulmonary Hypertension

2001 • 204 citations

Analysis of Nonsteroidal Antiinflammatory Drugs in Meconium and Its Relation to Persistent Pulmonary Hypertension of the Newborn

2001 • 204 citations

Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery

2003 • 190 citations

A Randomized Trial of Early Versus Standard Inhaled Nitric Oxide Therapy in Term and Near-Term Newborn Infants With Hypoxic Respiratory Failure

2004 • 185 citations

Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide

2002 • 181 citations

Effects of Inhaled Nitric Oxide on Pulmonary Edema and Lung Neutrophil Accumulation in Severe Experimental Hyaline Membrane Disease

1997 • 181 citations

Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs.

1989 • 180 citations

Stimulation of prostaglandin production through purinoceptors on cultured porcine endothelial cells

1983 • 170 citations

Ligating the Ductus Arteriosus before Birth Causes Persistent Pulmonary Hypertension in the Newborn Lamb

1989 • 165 citations

Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension

1997 • 157 citations

Improved Oxygenation in a Randomized Trial of Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn

1997 • 156 citations

Prostacyclin releases endothelium‐derived relaxing factor and potentiates its action in coronary arteries of the pig

1988 • 154 citations

New Treatments for Pulmonary Arterial Hypertension

2002 • 153 citations

Plasma Levels of Asymmetrical Dimethyl-l-Arginine in Patients with Congenital Heart Disease and Pulmonary Hypertension

2001 • 153 citations

The Stractural Basis of PPHN

1984 • 150 citations

High Glucose Impairs Voltage-Gated K ⁺ Channel Current in Rat Small Coronary Arteries

2001 • 142 citations

Inhaled Nitric Oxide in the Management of a Premature Newborn With Severe Respiratory Distress and Pulmonary Hypertension

1993 • 138 citations

Pulmonary Vascular Biology During Neonatal Transition

1999 • 129 citations

Bronchoalveolar Lavage with KL4-Surfactant in Models of Meconium Aspiration Syndrome

1998 • 123 citations

Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus

1997 • 119 citations

Ligating the Ductus Arteriosus before birth Remodels the Pulmonary Vasculature of the Lamb

1989 • 118 citations

Pulmonary Hypertension in the Perinatal Aspiration Syndromes

1977 • 116 citations

Response of premature infants with severe respiratory failure to inhaled nitric oxide

1997 • 114 citations

Oxidative stress and vascular damage in hypertension

2001 • 114 citations

Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn

1993 • 113 citations

Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease

2003 • 106 citations

Disruption of cGMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension

1995 • 104 citations

Phosphodiesterase inhibitors for persistent pulmonary hypertension of the newborn: A review

2003 • 102 citations

Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn

2000 • 102 citations

Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period

1997 • 97 citations

Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension

2003 • 96 citations

Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells.

1994 • 94 citations

Recombinant Human Superoxide Dismutase Enhances the Effect of Inhaled Nitric Oxide in Persistent Pulmonary Hypertension

2001 • 92 citations

Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension

1999 • 91 citations

Developmental Changes in Lung cGMP Phosphodiesterase-5 Activity, Protein, and Message

1998 • 91 citations

Coordinated Regulation of Genes of the Nitric Oxide and Endothelin Pathways during the Development of Pulmonary Hypertension in Fetal Lambs

1998 • 89 citations

Prostaglandin Inhibition Prevents the Fall in Pulmonary Vascular Resistance as a Result of Rhythmic Distension of the Lungs in Fetal Lambs

1991 • 88 citations

Decreased Gene Expression of Endothelial Nitric Oxide Synthase in Newborns with Persistent Pulmonary Hypertension

1998 • 86 citations

Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung

2002 • 85 citations

Randomized, Controlled Trial of Low-dose Inhaled Nitric Oxide in the Treatment of Term and Near-term Infants With Respiratory Failure and Pulmonary Hypertension

1999 • 84 citations

Aerosolised prostacyclin for pulmonary hypertension in neonates.

1994 • 83 citations

Interaction between Inhaled Nitric Oxide and Intravenous Sildenafil in a Porcine Model of Meconium Aspiration Syndrome

2004 • 79 citations

Targeting and translocation of endothelial nitric oxide synthase

1999 • 70 citations

Magnesium sulphate as an alternative and safe treatment for severe persistent pulmonary hypertension of the newborn.

1995 • 69 citations

Use of Inhaled Nitric Oxide

2000 • 66 citations

Use of Inhaled Nitric Oxide

2017 • 64 citations

Inhibition of Superoxide Generation from Neuronal Nitric Oxide Synthase by Heat Shock Protein 90: Implications in NOS Regulation

2002 • 63 citations

Ontogeny of cyclooxygenase-1 and cyclooxygenase-2 gene expression in ovine lung

1998 • 62 citations

Serum salicylate levels and right-to-left ductus shunts in newborn infants with persistent pulmonary hypertension

1980 • 61 citations

Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: Incidence and vasodilator therapy

1993 • 60 citations

Synergistic action of vasodilators that increase cGMP and cAMP in the hamster cremaster microcirculation

1994 • 59 citations

Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia

2004 • 58 citations

Changes in oxygenation and pulmonary haemodynamics in preterm infants treated with inhaled nitric oxide

1997 • 58 citations

Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension

1999 • 57 citations

Alveolar capillary dysplasia: a cause of persistent pulmonary hypertension of the newborn

2002 • 55 citations

Effects of Indomethacin on Fetal Rat Lungs: A Possible Cause of Persistent Fetal Circulation (PFC)

1981 • 55 citations

Prostacyclin Treatment for Persistent Pulmonary Hypertension of the Newborn

1997 • 55 citations

Adenosine Triphosphate and Adenosine Increase the Pulmonary Blood Flow to Postnatal Levels in Fetal Lambs

1992 • 48 citations

L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs

1991 • 46 citations

Adenosine infusion for the management of persistent pulmonary hypertension of the newborn*

2004 • 45 citations

Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects.

1994 • 43 citations

Recombinant human superoxide dismutase reduces lung injury caused by inhaled nitric oxide and hyperoxia

1997 • 41 citations

Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase.

1992 • 39 citations

Stimulation of soluble guanylate cyclase by superoxide dismutase is mediated by NO

1998 • 34 citations

Selective pulmonary vasodilation by low-dose infusion of adenosine triphosphate in newborn lambs

1991 • 33 citations

Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs

2002 • 33 citations

Purine nucleotides contribute to pulmonary vasodilation caused by birth-related stimuli in the ovine fetus

1997 • 33 citations

Adenosine Is a Pulmonary Vasodilator in Newborn Lambs

1992 • 31 citations

Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide*†

2001 • 28 citations

Successful weaning from cardiopulmonary bypass with central venous prostaglandin E1 and left atrial norepinephrine infusion in patients with acute pulmonary hypertension

1999 • 26 citations

Vitamin A prophylaxis

1997 • 25 citations

Prostacyclin aerosol in an infant with pulmonary hypertension

1995 • 24 citations

Role of magnesium sulphate in treatment of severe persistent pulmonary hypertension of the neoborn.

2002 • 24 citations

Prostacyclin aerosol in an infant with pulmonary hypertension

1995 • 23 citations

SUPPRESSIVE EFFECT OF PULMONARY HYPERTENSION AND LEUKOCYTE ACTIVATION BY INHALED PROSTAGLANDIN E 1 IN RATS WITH MONOCROTALINE-INDUCED PULMONARY HYPERTENSION

2002 • 13 citations

Comparative effects of beraprost, a stable analogue of prostacyclin, with PGE1, nitroglycerin and nifedipine on canine model of vasoconstrictive pulmonary hypertension

2001 • 13 citations

Preoperative prostaglandin El treatment to prevent right ventricular failure after orthotopic heart transplantation

1992 • 1 citations

Preoperative prostaglandin E1 treatment to prevent right ventricular failure after orthotopic heart transplantation

1992 • 1 citations

Deleted Work

1955 • 0 citations