Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

1971 • 1,054 citations

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

2002 • 763 citations

Antigen unmasking on formalin‐fixed, paraffin‐embedded tissue sections

1993 • 733 citations

Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension

2002 • 589 citations

Primary pulmonary hypertension

2003 • 526 citations

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1999 • 522 citations

Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

2003 • 499 citations

Sildenafil Inhibits Hypoxia-Induced Pulmonary Hypertension

2001 • 485 citations

Effect of Inhaled Iloprost Plus Oral Sildenafil in Patients With Primary Pulmonary Hypertension

2001 • 402 citations

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1999 • 397 citations

Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension

2003 • 381 citations

Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) Study

2005 • 379 citations

Vasoactive Substances Regulate Vascular Smooth Muscle Cell Apoptosis

1996 • 345 citations

Overall cardiovascular profile of sildenafil citrate

1999 • 313 citations

ET_A and ET_B Receptors Modulate the Proliferation of Human Pulmonary Artery Smooth Muscle Cells

2002 • 310 citations

Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp

2004 • 294 citations

Sildenafil for Long-Term Treatment of Nonoperable Chronic Thromboembolic Pulmonary Hypertension

2003 • 294 citations

Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation as a Sensitive Monitor of Defective Nitric Oxide/cGMP Signaling and Endothelial Dysfunction

2000 • 255 citations

Chronic Sildenafil Treatment Inhibits Monocrotaline-induced Pulmonary Hypertension in Rats

2003 • 253 citations

Phosphodiesterase Type 5 as a Target for the Treatment of Hypoxia-Induced Pulmonary Hypertension

2003 • 244 citations

Sildenafil Inhibits Altitude-induced Hypoxemia and Pulmonary Hypertension

2004 • 229 citations

Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

2002 • 216 citations

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

1994 • 182 citations

Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP

1998 • 163 citations

Expression of Three Isoforms of cGMP-Binding cGMP-Specific Phosphodiesterase (PDE5) in Human Penile Cavernosum

2000 • 159 citations

Prostacyclin Analogues Differentially Inhibit Growth of Distal and Proximal Human Pulmonary Artery Smooth Muscle Cells

2000 • 145 citations

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.

1997 • 136 citations

Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity

1998 • 133 citations

Cyclic Nucleotide Phosphodiesterase 1C Promotes Human Arterial Smooth Muscle Cell Proliferation

2002 • 121 citations

Expression, structure and chromosomal localization of the human cGMP‐binding cGMP‐specific phosphodiesterase PDE5A gene

1998 • 113 citations

A Combination of Oral Sildenafil and Beraprost Ameliorates Pulmonary Hypertension in Rats

2003 • 106 citations

Beneficial Effects of Phosphodiesterase 5 Inhibition in Pulmonary Hypertension Are Influenced by Natriuretic Peptide Activity

2003 • 97 citations

sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension

2001 • 97 citations

Vasodilator-Stimulated Phosphoprotein Regulates Proliferation and Growth Inhibition by Nitric Oxide in Vascular Smooth Muscle Cells

2004 • 95 citations

Molecular Cloning and Expression of Human cGMP-Binding cGMP-Specific Phosphodiesterase (PDE5)

1998 • 92 citations

Cl- current activation in choroid plexus epithelial cells involves a G protein and protein kinase A

1994 • 87 citations

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte‐macrophage differentiation of human U937 cells

2004 • 85 citations

Ca/CaM-Stimulated and cGMP-Specific Phosphodiesterases in Vascular and Non-Vascular Tissues

1991 • 84 citations

Signaling Molecules in Overcirculation-Induced Pulmonary Hypertension in Piglets

2004 • 82 citations

Tissue expression, distribution, and regulation of PDE5

2004 • 81 citations

The Role of the NO Axis and its Therapeutic Implications in Pulmonary Arterial Hypertension

2006 • 71 citations

Antimitogenic Actions of Organic Nitrates Are Potentiated by Sildenafil and Mediated Via Activation of Protein Kinase A

2001 • 67 citations

Regulation of Human PDE5A2 Intronic Promoter by cAMP and cGMP: Identification of a Critical Sp1-Binding Site

2001 • 56 citations

The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension.

2003 • 53 citations

Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery

2003 • 48 citations

Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery

2002 • 48 citations

Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation

2002 • 47 citations

Contribution of phosphodiesterase isoenzymes and cyclic nucleotide efflux to the regulation of cyclic GMP levels in aortic smooth muscle cells

1999 • 32 citations

Nitroprusside inhibits serotonin-induced mitogenesis and tyrosine phosphorylation of smooth muscle cells

1996 • 9 citations

Sildenafil citrate vs intracavernous alprostadil for patients with arteriogenic erectile dysfunction: a randomised placebo controlled study

2004 • 9 citations

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