CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

2006 • 3,752 citations

Interplay between Cortical Spreading Depolarization and Seizures

2017 • 3,543 citations

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

2007 • 3,382 citations

An Energy Budget for Signaling in the Grey Matter of the Brain

2001 • 3,148 citations

Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus

1990 • 979 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

Glutathione metabolism in brain

2000 • 740 citations

NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia

2004 • 562 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

2007 • 476 citations

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

2004 • 433 citations

Involvement of Microglial Receptor for Advanced Glycation Endproducts (RAGE) in Alzheimer's Disease: Identification of a Cellular Activation Mechanism

2001 • 412 citations

An immortalized cell line expresses properties of activated microglial cells

1992 • 356 citations

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel

1987 • 335 citations

Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity

2003 • 326 citations

β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils

1999 • 325 citations

Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

1997 • 318 citations

The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels

2003 • 311 citations

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

2008 • 309 citations

Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species

2002 • 293 citations

Isolation of Highly Infectious and Pure Adeno-Associated Virus Type 2 Vectors with a Single-Step Gravity-Flow Column

2001 • 289 citations

Activation of NADPH Oxidase in Alzheimer's Disease Brains

2000 • 286 citations

Amyloid β‐Peptide(1‐42) Contributes to the Oxidative Stress and Neurodegeneration Found in Alzheimer Disease Brain

2004 • 235 citations

NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide

2005 • 232 citations

Expression and Modulation of an NADPH Oxidase in Mammalian Astrocytes

2005 • 226 citations

The Intracellular Chloride Ion Channel Protein CLIC1 Undergoes a Redox-controlled Structural Transition

2004 • 212 citations

The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.

2006 • 211 citations

Crystal Structure of a Soluble Form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-Å Resolution

2001 • 203 citations

The large-conductance Ca2+-activated K+ channel is essential for innate immunity

2004 • 203 citations

Molecular Cloning and Expression of a Chloride Ion Channel of Cell Nuclei

1997 • 202 citations

Inflammatory changes parallel the early stages of Alzheimer disease

2006 • 193 citations

Surface Behavior and Lipid Interaction of Alzheimer β-Amyloid Peptide 1–42: A Membrane-Disrupting Peptide

2005 • 170 citations

Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with β-amyloid[25–35]

1999 • 155 citations

The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides

2005 • 152 citations

Measurement and Characterization of Superoxide Generation in Microglial Cells: Evidence for an NADPH Oxidase-Dependent Pathway

1998 • 137 citations

CLIC1 inserts from the aqueous phase into phospholipid membranes, where it functions as an anion channel

2002 • 130 citations

Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson’s disease

2006 • 124 citations

Recombinant CLIC1 (NCC27) Assembles in Lipid Bilayers via a pH-dependent Two-state Process to Form Chloride Ion Channels with Identical Characteristics to Those Observed in Chinese Hamster Ovary Cells Expressing CLIC1

2002 • 124 citations

Fibrillar beta-amyloid peptide Aβ1–40 activates microglial proliferation via stimulating TNF-α release and H2O2 derived from NADPH oxidase: a cell culture study

2006 • 124 citations

Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment

2006 • 115 citations

Involvement of the Intracellular Ion Channel CLIC1 in Microglia-Mediated -Amyloid-Induced Neurotoxicity

2004 • 114 citations

Functional characterization of the NCC27 nuclear protein in stable transfected CHO‐K1 cells

2000 • 102 citations

Redox Regulation of CLIC1 by Cysteine Residues Associated with the Putative Channel Pore

2005 • 98 citations

A key role for the microglial NADPH oxidase in APP-dependent killing of neurons

2005 • 95 citations

Potent regulation of microglia‐derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin

2006 • 92 citations

Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress

2005 • 85 citations

CLIC-5A Functions as a Chloride Channel in Vitro and Associates with the Cortical Actin Cytoskeleton in Vitro and in Vivo

2004 • 85 citations

Involvement of Stretch-Activated Cl⁻Channels in Ramification of Murine Microglia

1998 • 73 citations

A new vector, based on the PolII promoter for the U1 snRNA gene, for the expression of siRNAs in mammalian cells

2004 • 72 citations

AKAP350 at the Golgi Apparatus

2002 • 71 citations

Small‐conductance Cl^– channels contribute to volume regulation and phagocytosis in microglia

2007 • 54 citations

Interactions between NADPH oxidase and voltage‐gated proton channels: why electron transport depends on proton transport

2003 • 41 citations

Regulation of eosinophil membrane depolarization during NADPH oxidase activation

2003 • 37 citations

Consequences of the electrogenic function of the phagocytic NADPH oxidase

2005 • 30 citations

Microglial Cells

2004 • 1 citations