Measurement and Characterization of Superoxide Generation in Microglial Cells: Evidence for an NADPH Oxidase-Dependent Pathway

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Oxidative Stress in Neurodegenerative Diseases

1996 • 1,336 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

1997 • 1,281 citations

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

1997 • 923 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Enzyme-independent formation of nitric oxide in biological tissues

1995 • 783 citations

The origin and nature of ramified and amoeboid microglia: A historical review and current concepts

1993 • 682 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Production of superoxide anions by a CNS macrophage, the microglia

1987 • 619 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

1996 • 534 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

Free radicals and phagocytic cells

1995 • 487 citations

Dementia Associated with the Acquired Immunodeficiency Syndrome

1995 • 465 citations

Macrophages and the Nervous System

1991 • 429 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Physiology of oxygen radicals

1986 • 330 citations

Free radicals and myocardial ischemia: Overview and outlook

1988 • 286 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.

1994 • 251 citations

The Human Neutrophil Respiratory Burst Oxidase

1990 • 225 citations

Cytotoxic Effect of Brain Macrophages on Developing Neurons

1991 • 191 citations

Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.

1987 • 190 citations

Quantitative Measurement of Superoxide Generation Using the Spin Trap 5-(Diethoxyphosphoryl)-5-methyl- 1-pyrroline-N-oxide

1997 • 176 citations

Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system

1992 • 174 citations

Topological Mapping of Neutrophil Cytochrome b Epitopes with Phage-display Libraries

1995 • 162 citations

Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytes.

1990 • 145 citations

The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct

1993 • 119 citations

Detection of Superoxide Production by Activated Microglia Using a Sensitive and Specific Chemiluminescence Assay and Microglia‐Mediated PC12h Cell Death

1994 • 107 citations

The NADPH oxidase complex of phagocytic leukocytes: a biochemical and cytochemical view

1995 • 103 citations

Induction of Superoxide Anion and Nitric Oxide Production in Cultured Microglia^a

1994 • 94 citations

Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's desease

1994 • 75 citations

Respiratory burst activity in brain macrophages: a flow cytometric study on cultured rat microglia

1991 • 74 citations

Update on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide

1994 • 64 citations

A subpopulation of bone marrow‐derived macrophage‐like cells shares a unique ion channel pattern with microglia

1991 • 62 citations

Isolation and characterization of human fetal brain-derived microglia in in vitro culture

1991 • 47 citations

Identification and quantitation of free radicals and paramagnetic centers from complex multi-component EPR spectra

1993 • 22 citations

Involvement of the pertussis toxin-sensitive GTP-binding protein in regulation of expression and function of granulocyte complement receptor type 1 and type 3

1994 • 6 citations