NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide

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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

NOX enzymes and the biology of reactive oxygen

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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Neurovascular regulation in the normal brain and in Alzheimer's disease

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Viability thresholds and the penumbra of focal ischemia

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RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

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Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

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Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

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Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

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Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

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Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics

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Cerebral Blood Flow and Metabolism

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Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology

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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

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Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

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β-Amyloid-mediated vasoactivity and vascular endothelial damage

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NADPH oxidase

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Vascular risk factors for Alzheimer’s disease:

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Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

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Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?

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S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide

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Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O ₂ ⁻ and Systolic Blood Pressure in Mice

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Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

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β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

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NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

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A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

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P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease

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A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation

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Temporally Graded Requirement for Protein Synthesis following Memory Reactivation

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CD36 Mediates the Innate Host Response to β-Amyloid

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SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

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CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

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Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS) — correlation with simultaneous rCBF-PET measurements

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Ischemic Thresholds of Cerebral Protein Synthesis and Energy State following Middle Cerebral Artery Occlusion in Rat

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β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils

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Activation of NADPH Oxidase in Alzheimer's Disease Brains

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Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

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Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

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Endothelin-1 Induces NAD(P)H Oxidase in Human Endothelial Cells

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Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

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Cyclooxygenase-1 Participates in Selected Vasodilator Responses of the Cerebral Circulation

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Alterations in Cerebral Blood Flow and Glucose Utilization in Mice Overexpressing the Amyloid Precursor Protein

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Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

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Aβ-peptides enhance vasoconstriction in cerebral circulation

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Exogenous Aβ1–40 Reproduces Cerebrovascular Alterations Resulting from Amyloid Precursor Protein Overexpression in Mice

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Selective Nitration of Prostacyclin Synthase and Defective Vasorelaxation in Atherosclerotic Bovine Coronary Arteries

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Periventricular white matter lucency and cerebral blood flow autoregulation in hypertensive patients.

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Atherosclerosis of Cerebral Arteries in Alzheimer Disease

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Gene Transfer of Human Guanosine 5′-Triphosphate Cyclohydrolase I Restores Vascular Tetrahydrobiopterin Level and Endothelial Function in Low Renin Hypertension

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Aβ-Induced Vascular Oxidative Stress and Attenuation of Functional Hyperemia in Mouse Somatosensory Cortex

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Vasoactive effects of Aβin isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: Role of inflammation

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Plasma amyloid β, apolipoprotein E, lacunar infarcts, and white matter lesions

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Cerebral perfusion as a diagnostic marker of early Alzheimer's disease

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Characteristics of thein VitroVasoactivity of β-Amyloid Peptides

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Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles.

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Effects of a Novel Inhibitor of Guanylyl Cyclase on Dilator Responses of Mouse Cerebral Arterioles

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L-NA-Sensitive rCBF Augmentation during Vibrissal Stimulation in Type III Nitric Oxide Synthase Mutant Mice

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Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney

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Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats

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Increasing Required Neural Response to Expose Abnormal Brain Function in Mild Versus Moderate or Severe Alzheimer's Disease: PET Study Using Parametric Visual Stimulation

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Cortical NOS inhibition raises the lower limit of cerebral blood flow-arterial pressure autoregulation

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Nitric oxide participates in the cerebrovasodilation elicited from cerebellar fastigial nucleus

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Alzheimer's disease. A radical vascular connection.

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Exogenous NADPH Increases Cerebral Blood Flow Through NADPH Oxidase–Dependent and –Independent Mechanisms

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NEUROIMAGING IN DEMENTIA

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Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in vivo monocyte-to-macrophage differentiation

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Calcium ionophore and acetylcholine dilate arterioles on the mouse brain by different mechanisms.

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