Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Programmed cell death

1974 • 966 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

1998 • 857 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

The jun and fos protein families are both required for cell cycle progression in fibroblasts.

1991 • 442 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts

1997 • 365 citations

DNA damage and cell cycle checkpoints

1996 • 302 citations

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

1993 • 262 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Posttranscriptional regulation of c-fos mRNA expression

1987 • 215 citations

Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation.

1993 • 203 citations

Fos is an essential component of the mammalian UV response.

1995 • 200 citations

Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis.

1996 • 193 citations

Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression

1995 • 185 citations

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

1999 • 184 citations

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

1999 • 178 citations

The dual role model for p53 in maintaining genomic integrity

1999 • 150 citations

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1998 • 138 citations

Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

1999 • 134 citations

Programmed cell death in the absence of c-Fos and c-Jun

1996 • 127 citations

Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter

1995 • 120 citations

DNA double-strand breaks, chromosomal rearrangements, and genomic instability

1998 • 104 citations

Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling.

1998 • 93 citations

Ribozyme-mediated reversal of the multidrug-resistant phenotype.

1994 • 93 citations

p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.

1999 • 90 citations

A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs.

1997 • 77 citations

Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV

1985 • 75 citations

c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation

1995 • 74 citations

Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53

2000 • 63 citations

DNA damage, oncogenesis and the p53 tumour-suppressor gene

1994 • 62 citations

Cell proliferation and cell cycle progression are not impaired in fibroblasts and ES cells lacking c-Fos.

1995 • 60 citations

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families

1998 • 46 citations

Cytogenetic damage and the radiation-induced G1-phase checkpoint.

1996 • 45 citations

Critical steps in alkylation-induced aberration formation

1998 • 45 citations

Fundamentals for the Assessment of Risks from Environmental Radiation

1999 • 39 citations

Stress factors affecting expression of O6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells

1992 • 35 citations

Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53

1998 • 34 citations

Enhanced p53 activity and accumulation in response to DNA damage upon DNA transfection.

1995 • 30 citations

Inhibition of c-Fos expression in the UV-irradiated epidermis by topical application of antisense oligodeoxynucleotides suppresses activation of proliferating cell nuclear antigen

1995 • 23 citations

Apoptosis induced by X-rays and chemical agents in murine fibroblastic cell lines with a defect in repair of DNA double-strand breaks

1998 • 10 citations

Inducible Responses and Protective Functions of Mammalian Cells Upon Exposure to UV Light and Ionizing Radiation

1999 • 4 citations

Apoptosis induced by X-rays and chemical agents in murine fibroblastic cell lines with a defect in repair of DNA double-strand breaks

1999 • 1 citations