Apoptosis induced by X-rays and chemical agents in murine fibroblastic cell lines with a defect in repair of DNA double-strand breaks

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

1988 • 1,434 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

The role of proteases during apoptosis

1996 • 558 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

1996 • 425 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

Catalytic function of DNA topoisomerase II

1991 • 246 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

1997 • 196 citations

Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response

1997 • 156 citations

DNA-dependent Protein Kinase Is a Target for a CPP32-like Apoptotic Protease

1996 • 123 citations

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage

1995 • 122 citations

Ionizing Radiation-induced Cell Death

1994 • 119 citations

Radiation-induced apoptosis in a murine T-cell hybridoma.

1992 • 116 citations

Apoptosis: an indicator of radiosensitivity in vitro ?

1997 • 91 citations

Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors.

1989 • 88 citations

A Role for Calcium in Regulating Apoptosis in Rat Thymocytes Irradiatedin Vitro

1992 • 82 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

Correlation of Micronucleus and Apoptosis Assays with Reproductive Cell Death

1995 • 74 citations

Review: The molecular regulation of apoptosis and implications for radiation oncology

1997 • 71 citations

Radiation-induced apoptosis in sensitive and resistant cells isolated from a mouse lymphoma.

1994 • 70 citations

Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response

1995 • 68 citations

Reducing the radiation-induced G2 delay causes HeLa cells to undergo apoptosis instead of mitotic death

1996 • 66 citations

Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: influence of H-ras on the G2 delay.

1996 • 65 citations

Cellular and chromosomal hypersensitivity to DNA crosslinking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: phenotypic similarities to ataxia telangiectasia and Fanconi's anaemia cells

1993 • 54 citations

Two-stage Cell Shrinkage and the OER for Radiation-induced Apoptosis of Rat Thymocytes

1993 • 51 citations

Mouse Lymphoma Cells that Undergo Interphase Death Show Markedly Increased Sensitivity to Radiation-induced DNA Double-strand Breakage as Compared with Cells that Undergo Mitotic Death

1991 • 46 citations

Functional complementation in mouse — human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8

1993 • 45 citations

Radiosensitivity, Apoptosis and Repair of DNA Double-Strand Breaks in Radiation-Sensitive Chinese Hamster Ovary Cell Mutants Treated at Different Dose Rates

1996 • 40 citations

Characterization of radiation-induced apoptosis in rodent cell lines.

1997 • 39 citations

CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme

1996 • 37 citations

Hypertonic treatment does not affect the radiation yield of interphase chromosome breaks in DNA double-strand break repair-deficient xrs-5 cells.

1993 • 27 citations

Cultured Cells from a Severe Combined Immunodeficient Mouse Have a Slower Than Normal Rate of Repair of Potentially Lethal Damage Sensitive to Hypertonic Treatment

1995 • 14 citations

Sensitivity to inhibitors of type II topoisomerases from mouse L5178Y lymphoma strains that are resistant or sensitive to X-radiation

1993 • 3 citations