Exogenous Nitric Oxide Can Trigger a Preconditioned State Through a Free Radical Mechanism, But Endogenous Nitric Oxide Is Not a Trigger of Classical Ischemic Preconditioning

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

Guide for the care and use of laboratory animals

1997 • 3,181 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts

1995 • 524 citations

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

1993 • 521 citations

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

1997 • 490 citations

Nitric Oxide in the Vasculature: Physiology and Pathophysiology

1997 • 348 citations

Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts

1997 • 339 citations

Oxygen Radicals Can Induce Preconditioning in Rabbit Hearts

1997 • 294 citations

Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.

1993 • 274 citations

The nitric oxide hypothesis of late preconditioning

1998 • 274 citations

Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase

1999 • 273 citations

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

1994 • 272 citations

Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits

1999 • 258 citations

alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.

1994 • 258 citations

Preconditioning of the ischaemic myocardium; involvement of the <scp>l</scp>‐arginine nitric oxide pathway

1992 • 238 citations

Nitric Oxide Donors Induce Late Preconditioning Against Myocardial Stunning and Infarction in Conscious Rabbits via an Antioxidant-Sensitive Mechanism

1998 • 210 citations

Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size

1992 • 184 citations

Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury

1995 • 176 citations

Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium

1995 • 161 citations

Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart

1993 • 160 citations

Signal Transduction in Ischemic Preconditioning:

1999 • 154 citations

Inhibition of Nitric Oxide Synthesis Reduces Infarct Size by an Adenosine-Dependent Mechanism

1995 • 154 citations

Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits

1997 • 151 citations

Classic Preconditioning Decreases the Harmful Accumulation of Nitric Oxide During Ischemia and Reperfusion in Rat Hearts

1999 • 137 citations

Protection Against Ischemic Injury by Nonvasoactive Concentrations of Nitric Oxide Synthase Inhibitors in the Perfused Rabbit Heart

1995 • 135 citations

Role of nitric oxide, muscarinic receptors, and the ATP-sensitive K+ channel in mediating the effects of acetylcholine to mimic preconditioning in dogs.

1993 • 134 citations

Loss of Pacing-induced Preconditioning in Rat Hearts: Role of Nitric Oxide and Cholesterol-enriched Diet

1997 • 126 citations

Activation of nitric oxide synthase by ischaemia in the perfused heart

1997 • 107 citations

Contribution of NO to Ischemia-Reperfusion Injury in the Saline-Perfused Heart: a Study in Endothelial NO Synthase Knockout Mice

1999 • 100 citations

Sustain inhibition of nitric oxide by NG-nitro-l-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart

1995 • 98 citations

Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?

1997 • 95 citations

Pretreatment with Endothelin-1 Mimics Ischemic Preconditioning Against Infarction in Isolated Rabbit Heart

1996 • 91 citations

Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog

1995 • 89 citations

Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit

1995 • 80 citations

Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts

1995 • 77 citations

No Involvement of Endogenous Nitric Oxide In Classical Ischemic Preconditioning in Swine

2000 • 75 citations

Nitric oxide synthase protects the heart against ischemia-reperfusion injury in rabbits.

1995 • 68 citations

The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning

1992 • 66 citations

Determination of Rate Constants of the Reactions of Thiols with Superoxide Radical by Electron Paramagnetic Resonance: Critical Remarks on Spectrophotometric Approaches

1996 • 62 citations

Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury*1

1995 • 60 citations

Bradykinin Protects Against Infarction but Does not Mediate Ischemic Preconditioning in the Isolated Rat Heart

1996 • 51 citations

Does the Antiarrhythmic Effect of Ischemie Preconditioning in Rats Involve the L-Arginine Nitric Oxide Pathway?

1995 • 49 citations

Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog

1995 • 39 citations

Endogenous nitric oxide (NO) protects against ischaemia-reperfusion injury in the rabbit

1995 • 34 citations

Delayed myocardial protection following ischaemic preconditioning

1996 • 20 citations

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function

1999 • 20 citations

INHIBITION OF NITRIC OXIDE DOES NOT AFFECT REPERFUSION-INDUCED MYOCARDIAL INJURY, BUT IT PREVENTS LIPID PEROXIDATION IN THE ISOLATED RAT HEART

1997 • 17 citations

Enhancement of neutrophil response by SH-containing compounds: Modulation of superoxide and hydrogen peroxide production

1984 • 16 citations

Protective effect of preconditioning on coronary occlusion induced arrhythmia involve prostaglandins

1992 • 15 citations

Ischaemic preconditioning is not prevented by inhibition of endothelium-derived nitric oxide

1992 • 8 citations