Bortezomib Inhibits Cell-Cell Adhesion and Cell Migration and Enhances Epidermal Growth Factor Receptor Inhibitor–Induced Cell Death in Squamous Cell Cancer

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma

2005 • 2,457 citations

Focal adhesion kinase: the first ten years

2003 • 1,360 citations

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

1988 • 1,288 citations

The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

2005 • 1,006 citations

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 • 846 citations

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

2002 • 817 citations

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

1997 • 702 citations

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

2000 • 661 citations

The proteasome: structure, function, and role in the cell

2003 • 558 citations

NEW EMBO MEMBER'S REVIEW: The integrin-actin connection, an eternal love affair

2003 • 480 citations

Proteasome Inhibitor PS-341 Induces Apoptosis through Induction of Endoplasmic Reticulum Stress-Reactive Oxygen Species in Head and Neck Squamous Cell Carcinoma Cells

2004 • 429 citations

Control of motile and invasive cell phenotypes by focal adhesion kinase

2004 • 425 citations

Multiple connections link FAK to cell motility and invasion

2003 • 402 citations

Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2

1999 • 395 citations

The ins and outs of E-cadherin trafficking

2004 • 356 citations

The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation

2006 • 354 citations

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

2002 • 351 citations

Working out the strength and flexibility of desmosomes

2004 • 334 citations

The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes

1997 • 237 citations

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells

1999 • 234 citations

Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy

2005 • 224 citations

RAC1 Regulates Adherens Junctions through Endocytosis of E-Cadherin

2001 • 198 citations

The Role of the E-Cadherin/Catenin Adhesion Complex in the Development and Progression of Cancer

1999 • 195 citations

Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature

2001 • 181 citations

E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function

2005 • 175 citations

Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses.

2003 • 174 citations

Ligand-induced Lysosomal Epidermal Growth Factor Receptor (EGFR) Degradation Is Preceded by Proteasome-dependent EGFR De-ubiquitination

2003 • 171 citations

Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells

2002 • 166 citations

High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype

2005 • 162 citations

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

2002 • 152 citations

Epidermal Growth Factor Receptor Inhibition Promotes Desmosome Assembly and Strengthens Intercellular Adhesion in Squamous Cell Carcinoma Cells

2004 • 148 citations

Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells.

2002 • 125 citations

Negative regulation of FAK signaling by SOCS proteins

2003 • 106 citations

Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer

2005 • 87 citations

Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase

2003 • 82 citations

Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx

2003 • 69 citations

De novo formation of desmosomes in cultured cells upon transfection of genes encoding specific desmosomal components

2003 • 67 citations

Cell-Cell Dissociation upon Epithelial Cell Scattering Requires a Step Mediated by the Proteasome

1999 • 61 citations

Specific induction of pp125 focal adhesion kinase in human breast cancer

2005 • 57 citations

Focal Adhesion Kinase Overexpression in Endometrial Neoplasia

2004 • 51 citations

Down‐regulation of desmosomal molecules in oral and pharngeal squamous cell carcinomas as a marker for tumour growth and distant metastasis

1999 • 46 citations

The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas

2003 • 43 citations

Bortezomib (Velcade) for progressive myeloma after autologous stem cell transplantation and thalidomide

2005 • 18 citations

The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas

2003 • 10 citations